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| 1 | Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI显示文摘 | Wang L Zang Y He Y Liang M Zhang X Tian L Wu T Jiang T Li K | 2006 | 中国生物学文摘2006，20，10： | 84 |
| 2 | Severe acute pancreatitis: Clinical course and management显示文摘Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. Morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (MOFS) occurs in the later course after the first week. To predict sepsis, MOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%. | Hans G Beger Bettina M Rau | 2007 | World Journal of Gastroenterology2007，13，38： | 122 |
| 3 | DOG1是一种敏感和特异性的胃肠道间质瘤的标记物显示文摘 | Espinosa I Lee C H Kim M K 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 117 |
| 4 | 血栓形成的抗栓治疗和预防,第9版:美国胸科医师学院循证的临床实践指南显示文摘【缩写】ACS=急性冠脉综合征;AF=心房纤颤;AIS=动脉性缺血性卒中;APLA=抗磷脂抗体;ASA=阿司匹林;AT9=第9版血栓的抗栓治疗和预防:美国胸科医师学院循证的临床实践指南;BMS=裸金属支架;CABG=冠状动脉旁路移植术;CAD=冠状动脉疾病;CDT=导管接触溶栓;CHADS2=充血性心力衰竭,高血压,年龄≥75岁,糖尿病,有卒中或TIA病史; | 潘元美 曹雯炜 秦洁行 周洁茹 金海峰 朱莹 李焰生 Guyatt GH Akl EA Crowther M Gutterman DD Schu nemann HJ | 2012 | 神经病学与神经康复学杂志2012，9，1： | 195 |
| 5 | PBL教学法与CBL教学法的比较——基于两种教学法的转换在临床课程学习上的效果分析显示文摘本文通过调查加州大学洛杉矶分校(UCLA)和加州大学戴维斯分校(UCD)学生和教师对以问题为基础的学习(PBL)和以案例为基础的学习(CBL)的认知和感受,结果发现,89%的学生和84%的教师更倾向于CBL教学法,两校教师和学生都认为CBL的引导式探究优于PBL的开放式探究。 | Srinivasan M 夏颖 顾鸣敏 | 2009 | 复旦教育论坛2009，7，5： | 139 |
| 6 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 7 | 欧洲新生儿呼吸窘迫综合征防治指南-2010版显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为生后当时或很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡,存活者,在生后2—4d病情开始改善。胎龄越小,RDS发生率越高,2006年EuroNeoStat的数据显示:胎龄23~25周的早产儿RDS发生率为91%, | Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) | 2011 | 中华儿科杂志2011，49，1： | 137 |
| 8 | 利用 RFLP、SSR、AFLP和 RAPD标记分析玉米自交系遗传多样性的比较研究显示文摘利用 RFLP、SSR.AFLP和RAPD 4种分子标记方法研究了 15个玉米(Zea mays L.)自交系的遗传多样性,同时对4种标记系统进行比较。在供试材料中筛选到具多态性的RFLP探针酶组合56个,66对SSR引物,20个RAPD引物和9个AFLP引物组合,分别检测到多态性带167、201、87和108条。SSR标记位点的平均多态性信息量(PIC)最大(0.54),AFLP标记位点最小(0.36),但AFLP标记具有最高的多态性检测效率(Ai,32.2)。4种分子标记所得遗传相似系数相关性显著,比较相关系数表明 RAPD可靠性较低。依据 4种分子标记结果将 15个供试自交系划分为塘四平头、旅大红骨、兰卡斯特、瑞德和PN共5个类群,与系谱分析基本一致。认为SSR和RFLP两种分子标记方法适合进行玉米种质遗传多样性的研究。 | 袁力行 傅骏骅 Warburton M 李新海 张世煌 Khairallah M 刘新芝 彭泽斌 李连城 | 2000 | Acta Genetica Sinica2000，27，8： | 257 |
| 9 | The biological stress of early weaned piglets显示文摘Pigs experience biological stress such as physiological, environmental, and social challenges when weaned from the sow. The process of weaning is one of the most stressful events in the pig's life that can contribute to intestinal and immune system dysfunctions that result in reduced pig health, growth, and feed intake, particularly during the first week after weaning. Technological improvements in housing, nutrition, health, and management have been used to minimize some of the adverse effects of weaning stress, but a greater understanding of the biological impact of stress is needed to improve strategies to overcome weaning stress. The focus of this review paper is to briefly describe how the biological stress associated with weaning impacts intestinal morphology, structure, physiology, and intestinal immune responses that can impact subsequent production efficiencies such as growth, intake, morbidity, and mortality. | Joy M Campbell Joe D Crenshaw Javier Polo | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 83 |
| 10 | 利用RFLP和SSR标记划分玉米自交系杂种优势群的研究显示文摘利用 RFL P和 SSR标记对 2 9个玉米自交系进行杂种优势群划分 ,筛选出 56个多态性 RFL P探针酶组合 ,6 6对多态性 SSR引物 ,分别在供试材料中检测到 187个和 2 32个等位基因变异。两种方法比较表明 ,SSR标记的平均多态性信息量 (PIC,0 .54)高于 RFLP(0 .4 2 ) ;但对供试材料的遗传多样性评价基本一致 ,平均遗传相似系数 (GS)分别为 0 .6 4和 0 .6 2。综合 RFL P和 SSR分析结果进行聚类分析 ,将供试材料划分为四平头 ,旅大红骨 ,L SC,BSSS和 PA五个类群 ,划分结果与系谱分析基本一致 ,并把系谱来源不清的种质划分到相应的杂种优势群。其中 PN群的确认 ,进一步完善了我国玉米种质杂种优势群的基本框架 ,为育种实践提供了有价值的信息。 | 袁力行 傅骏骅 张世煌 刘新芝 彭泽斌 李新海 Khairalla M | 2001 | 作物学报2001，27，2： | 133 |
| 11 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 12 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 13 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 14 | 激光剥蚀信号在线平滑和去汞装置:原位微区铅同位素准确分析利器显示文摘激光原位微区分析可在微观尺度上完成样品的元素定量分析或同位素组成测定,为研究成岩、成矿物质来源和追踪地壳与地幔演化历史提供了独特的观察视野。但是,激光剥蚀等离子体质谱的一些缺陷阻碍了地质样品的高精度、高空间分辨率分析,比如:剥蚀池的位置效应、低剥蚀速率下信号波动影响、激光剥蚀脉动式信号导致的光谱螺纹效应、高频激光剥蚀造成的元素分馏效应等。为此,一些学者设计了不同规格和样式的激光剥蚀信号平滑装置来克服这些问题。但是,这些信号平滑装置普遍还存在气体吹扫时间过长和降低激光剥蚀信号灵敏度等问题。因此,研制新型的信号平滑装置对改善LA—ICP—MS的数据质量具有重要的意义。 | Hu Z Zhang W Liu Y Gao S Li M Zong K Chen H Hu S 刘勇胜 | 2015 | 矿物岩石地球化学通报2015，34，4： | 114 |
| 15 | 新媒体联盟地平线报告:2017高等教育版显示文摘《新媒体联盟地平线报告:2017高等教育版》由美国新媒体联盟与美国高校教育信息化协会学习促进会协作完成。来自5大洲22个国家的78位不同角色的专家选择了最有可能影响今后五年(2017—2021)技术规划和决策制定的六项主要趋势、六个关键挑战和六种重要技术,详细阐释了共18个主题的内容。本年度报告将18个主题内容分为六个元分类,并对每个内容进行元分类标注。从2017年的报告当中,我们既能够见到'混合式学习'、'自适应性学习'、'移动学习'等熟悉的主题,又能够看到'人工智能'、'自然用户界面'等新兴技术的最新进展。本报告对于指导各国政府和高等院校推进教育信息化工作具有宏观指导价值。 | S·亚当斯贝克尔 M·卡明斯 A·戴维斯 A·弗里曼 C·霍尔给辛格 V·安娜塔娜额亚婻 殷丙山(译) 高茜(译) 任直(译) 刘鑫驰(译) 曹红岩(译) 王济军(译) 赵广元(译) 邵恒(译) | 2017 | 开放学习研究2017，22，2： | 81 |
| 16 | Current concepts on osteonecrosis of the femoral head显示文摘It is estimated that 20000 to 30000 new patients are diagnosed with osteonecrosis annually accounting for approximately 10% of the 250000 total hip arthroplasties done annually in the United States. Thelack of level 1 evidence in the literature makes it difficult to identify optimal treatment protocols to manage patients with pre-collapse avascular necrosis of the femoral head, and early intervention prior to collapse is critical to successful outcomes in joint preserving procedures. There have been a variety of traumatic and atraumatic factors that have been identified as risk factors for osteonecrosis, but the etiology and pathogenesis still remains unclear. Current osteonecrosis diagnosis is dependent upon plain anteroposterior and frog-leg lateral radiographs of the hip, followed by magnetic resonance imaging(MRI). Generally, the first radiographic changes seen by radiograph will be cystic and sclerotic changes in the femoral head. Although the diagnosis may be made by radiograph, plain radiographs are generally insufficient for early diagnosis, therefore MRI is considered the most accurate benchmark. Treatment options include pharmacologic agents such as bisphosphonates and statins, biophysical treatments, as well as joint-preserving and joint-replacing surgeries. the surgical treatment of osteonecrosis of the femoral head can be divided into two major branches: femoral head sparing procedures(FHSP) and femoral head replacement procedures(FHRP). In general, FHSP are indicated at pre-collapse stages with minimal symptoms whereas FHRP are preferred at post-collapse symptomatic stages. It is difficult to know whether any treatment modality changes the natural history of core decompression since the true natural history of core decompression has not been delineated. | Joaquin Moya-Angeler Arianna L Gianakos Jordan C Villa Amelia Ni Joseph M Lane | 2015 | World Journal of Orthopedics2015，6，8： | 94 |
| 17 | IMbrave150研究:免疫抑制剂治疗首次取得晚期肝细胞癌一线治疗成功显示文摘【据The New England Journal of Medicine 2020年5月报道】题:阿特朱单抗联合贝伐单抗在无法手术切除的晚期肝细胞癌中的疗效(作者Finn RS等)索拉非尼和仑伐替尼是目前晚期肝细胞癌(HCC)的标准一线治疗方案,可适当提高患者总生存率,但不良反应较多。PD-1抑制剂、阿特朱单抗(PD-L1抑制剂)以及贝伐单抗在Ⅰb期和Ⅱ期临床试验中显示出良好的客观缓解率。该研究探索了阿特朱单抗联合贝伐单抗对比单药索拉非尼治疗无法手术切除的晚期HCC的疗效和安全性。 | 刘昊天 钟鉴宏 FINN RS QIN S IKEDA M | 2020 | 临床肝胆病杂志2020，36，9： | 460 |
| 18 | 新辅助免疫治疗可以为MMR表达以及MMR缺失型早期结肠癌患者带来病理缓解显示文摘PD-1联合CTLA-4阻滞剂对晚期错配修复蛋白(MMR)缺失(dMMR)型结直肠癌患者的治疗非常有效,但对MMR表达(pMMR)的患者无效。我们假设在早期结肠癌患者中新辅助免疫疗法具有更好的疗效。在探索性NICHE研究中(Clinical Trials.gov:NCT03026140),dMMR或pMMR患者在手术前接受单剂量伊匹单抗(ipilimumab)和两剂量纳武单抗(nivolumab)治疗,pMMR患者联合或者不联合使用塞来昔布。本研究的主要观察指标是安全性和可行性。在纳入分析的40例患者中,包括21例dMMR患者和19例pMMR患者,他们均接受了治疗,其中3例经安全性讨论后仅接受了纳武单抗单药治疗。患者治疗耐受性良好,所有患者均接受了根治性切除且未延期进行,符合主要观察指标的观察预期。在接受伊匹单抗+纳武单抗治疗的患者(20例dMMR患者和15例pMMR患者)中,共35例可进行疗效和转化效果评估。在20例dMMR患者中,病理缓解率为100%(95%CI:86%~100%),有19例患者达到主要病理缓解(MPRs,残留存活肿瘤≤10%),其中包括12例患者达到完全病理缓解。在15例pMMR患者中,有4例达到病理缓解,其中包括3例主要病理缓解和1例部分缓解。CD8+PD-1+T细胞浸润情况可预测pMMR患者的治疗应答。基于这些数据认为,如果新辅助免疫治疗效果能被基于至少3年无病生存数据的更加大型的临床研究结果支持,那么其则有望作为特定结肠癌患者的标准治疗方案。 | 张荣欣 CHALABI M FANCHI L F DIJKSTRA K K | 2020 | 结直肠肛门外科2020，26，6： | 87 |
| 19 | Cellular and molecular mechanisms in the pathogenesis of liver fibrosis:An update显示文摘There have been considerable recent advances towards a better understanding of the complex cellular and molecular network underlying liver fibrogenesis.Recent data indicate that the termination of fibrogenic processes and the restoration of deficient fibrolytic pathways may allow the reversal of advanced fibrosis and even cirrhosis.Therefore,efforts have been made to better clarify the cellular and molecular mechanisms that are involved in liver fibrosis.Activation of hepatic stellate cells(HSCs)remains a central event in fibrosis,complemented by other sources of matrix-producing cells,including portal fibroblasts,fibrocytes and bone marrow-derived myofibroblasts.These cells converge in a complex interaction with neighboring cells to provoke scarring in response to persistent injury.Defining the interaction of different cell types,revealing the effects of cytokines on these cells and characterizing the regulatory mechanisms that control gene expression in activated HSCs will enable the discovery of new therapeutic targets.Moreover,the characterization of different pathways associated with different etiologies aid in the development of disease-specific therapies.This article outlines recent advances regarding the cellular and molecular mechanisms involved in liver fibrosis that may be translated into future therapies.The pathogenesis of liver fibrosis associated with alcoholic liver disease,non-alcoholic fatty liver disease and viral hepatitis are also discussed to emphasize the various mechanisms involved in liver fibrosis. | Gülsüm ?zlem Elpek | 2014 | World Journal of Gastroenterology2014，20，23： | 82 |
| 20 | 2004年中国大气污染造成的健康经济损失评估显示文摘 大气污染造成的健康危害是环境污染损失评价中最重要的组成部分,同时,也是难度最大、最具争议性的一个研究热点.关于大气污染健康危害的经济损失评价有两个主要难点,一是大气污染引发的过早死亡人数以及住院和发病人次的确定,即危害量的确定,二是危害量的货币化,即受危害人群过早死亡或患病带来的经济损失如何确定.笔者对评估大气污染造成的健康影响涉及的主要问题进行了探讨,并对我国2004年大气污染造成的健康经济损失进行了评估.…… | 於方 过孝民 张衍燊 潘小川 赵越 王金南 曹东 Cropper M Aunan K | 2007 | 环境与健康杂志2007，24，12： | 61 |
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