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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Inflammatory bowel disease course in Crohn's disease:Is the natural history changing?显示文摘Crohn’s disease(CD)is a multifactorial potentially debilitating disease.It has a variable disease course,but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability.Studies on the natural history of CD provide invaluable data on its course and clinical predictors,and may help to identify patient subsets based on clinical phenotype.Most data are available from referral centers,however these outcomes may be different from those in population-based cohorts.New data suggest the possibility of a change in the natural history in Crohn’s disease,with an increasing percentage of patients diagnosed with inflammatory disease behavior.Hospitalization rates remain high,while surgery rates seem to have decreased in the last decade.In addition,mortality rates still exceed that of the general population.The impact of changes in treatment strategy,including increased,earlier use of immunosuppressives,biological therapy,and patient monitoring on the natural history of the disease are still conflictive.In this review article,the authors summarize the available evidence on the natural history,current trends,and predictive factors for evaluating the disease course of CD. | Petra A Golovics Michael D Mandel Barbara D Lovasz Peter L Lakatos | 2014 | World Journal of Gastroenterology2014，20，12： | 2 |
| 3 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | Infectious Diseases Society of Amerlca/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults显示文摘 | Mandell LA Wunderink RG Anzueto A | 2007 | Clin Infect Dis2007，44，2： | 1 |
| 5 | Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in aduhs显示文摘 | Mandell LA Wunderink RG Anzueto A | 2007 | Clin Infect Dis2007，442，： | 1 |
| 6 | InfectiousDiseases Society of America/ American Thoracic Societyconsensus guidelines on the management of community-acquired pneumo-nia in adults 显示文摘 | Mandell LA Wunderink RG Anzueto A | 2007 | Clin Infect Dis2007，44，2： | 1 |
| 7 | Infections Diseases Society of America/ American Thoracic Society consensus guidelines on the management of community- acquired pneumonia in adults显示文摘 | Mandell LA Wunderink RG Anzueto A | 2007 | Clin infect Dis2007，442，： | 1 |
| 8 | Dopaminergic transplants normalize amphetamine-and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum显示文摘 | Cenci M A Kalen P Mandel R J | 1992 | Neuroscienee1992，46，： | 1 |
| 9 | Infectious Dis-eases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults显示文摘 | Mandell LA Wunderink RG Anzueto A | 2007 | CID2007，44，2： | 1 |
| 10 | A randomized,controlld,clinical trial of etoricoxib in the treatment of rheumatoid arthritis显示文摘 | Matsumoto AK Melian A Mandel DR | 2002 | J Rheumatol2002，29，： | 1 |
| 11 | Calcium-dependent bacteriophage DNA infection显示文摘 | Mandel M Higa A | 1970 | J Mol Biol1970，53，1： | 1 |
| 12 | Molecu- lar characterization of the Arabidopsis floral homeotic gene APETELA1 显示文摘 | Mandel M A Gustafson-Brown C Savidge B | 1992 | Nature1992，360，6401： | 1 |
| 13 | Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho related signaling 显示文摘 | Babbin B A Parkos C A Mandell K J | 2007 | The American Journal of Pathology2007，170，95： | 1 |
| 14 | The Arabidopsis AGL8 MADS-box gene is expressed in inflorescence mer- istems and is negatively regulated by APETALA1 显示文摘 | MANDEL M A YANOFSKY M F | 1995 | Plant Cell1995，7，： | 1 |
| 15 | The patterns of gene expression in the tomato shoot apical meristem显示文摘 | Fleming A J Mandel T Roth I | | 0，，： | 1 |
| 16 | Infectious Diseases Society of American/American Thoracic Society consensus guidelines on management of community-acquired pneumonia in adules 显示文摘 | Mandell LA Wunderink RG Anzueto A et aI | 2007 | Clin Infect Dis2007，44，2： | 1 |
| 17 | Phosphate recovery from wastewater using engineered superparamagnetic particles modified with layered double hydroxide ion exchangers 显示文摘 | DRENKOVA-TUHTAN A MANDEL K PAULUS A | 2013 | Water Research2013，47，15： | 1 |
| 18 | On the mechanism of light activation of retinal rod outer segments cyclic GMP phosphodiesterase (light activation-influence of bleached rhodopsin and KF-deinhibition)显示文摘 | SITARAMAYYA A Virmaux N Mandel P | 1977 | Exp Eye Res1977，25，： | 1 |
| 19 | Infectious diseases so- ciety of America/American Thorocic society consensus guidelines on the management of community-acquired pneumonia in adults 显示文摘 | Mandell LA Wunderink RG Auzu- eto A | 2007 | CID2007，44，2： | 1 |
| 20 | TheArabidopsis AGL8 MADS box gene is expressed in inflorescence meristems and is nega- tively regulated by APETALA 1 显示文摘 | Mandel A M Yanofsky M F | 1995 | The Plant Cell1995，7，11： | 1 |
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