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589篇 您的检索式：作者名="A Tremblay"

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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	Microsatellite analysis of genetic diversity in four populations of Populus tremuloids in Quebec显示文摘	Wyman J Bruneau A Tremblay M F	2003	Can J Bot2003，81，：	1
3	1/f Noise in Random Resistor Networks:Fractals and Percolating Systems显示文摘	Tannous C Tremblay A M S	1985	Phys Rev A1985，31，：	1
4	An intercompariaon of mesoseale forecasts of aircraft icing using SSM/I retrievals 显示文摘	Tremblay A Cober S G Glazer A	1996	Weather and Forecasting1996，11，：	1
5	Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo 显示文摘	DOHERTY A S MANN M R TREMBLAY K D	2000	Biology of Reproduction2000，62，：	1
6	Active Video Games and Health Indicators in Children and Youth: A Systematic Review 显示文摘	LeBlanc A Chaput J Tremblay M	2013	Plos ONE2013，，6：	1
7	Annual follow-up of gross diffusive carbon dioxide and methane emissions from a boreal reservoir and two nearby lakes in Qu@bec, Canada 显示文摘	DEMARTY M BASTIEN J TREMBLAY A	2011	Biogeosciences2011，8，1：	1
8	The role of microglia in the healthy brain显示文摘	Tremblay ME Stevens B Sierra A	2011	The Journal of neuroscience:the official journal of the Society for Neuroscience2011，31，16：	1
9	The mesoscale dy namics of freezing rain storms over eastern Canada显示文摘	Szeto K K Tremblay A Guan H	1999	J At mos Sci1999，56，10：	1
10	Hyperhomocysteinemia in hemodialysis patients: effects of 12- month supplementation with hydrosoluble vitamins显示文摘	Tremblay R Bonnardeaux A Geadah D	2000	Kidney Int2000，58，2：	1
11	The N-terminal domain that distinguishes yeast from bacterial RNase Ⅲ contains a dimerization signal required for efficient double-stranded RNA cleavage 显示文摘	Lamontagne B Tremblay A Abou Elela S	2000	Mol Cell Biol2000，20，4：	1
12	Negative energy balance with exercise in identical twins: plasma glucose and insulin responses 显示文摘	Oppert JM Nadeau Am Tremblay A	1997	Am J Physiol1997，272，：	1
13	Atorvastatin increa- ses intestinal expression of NPC1 L! in hyperlipidemic men 显示文摘	Tremblay A J Lamarche B Lemelin V	2011	J Lipid Res2011，52，3：	1
14	The role of microglia in the healthy brain显示文摘	Tremblay ME Stevens B Sierra A	2011	J Neurosci2011，31，16：	1
15	The emergence of porcine circovirus 2b genotype (PCV-2b) in swine in Canada显示文摘	Gagnon C A Tremblay D Tijssen P		0，，08：	1
16	The role of protein tyrosine phosphatase 1B in Ras signaling 显示文摘	Dub N Cheng A Tremblay ML	2004	Proc Nail Acad Sci USA2004，101，7：	1
17	Discovery of a potent and orally active hedgehog pathway antagonist(IPI-926)显示文摘	Tremblay M R Lescarbeau A Grogan M J	2009	Journal of Medicinal Chemistry2009，52，14：	1
18	An improved modeling scheme for freezing precipitation forecasts显示文摘	Tremblay A Glazer A	2000	Mon Wea Rev2000，128，12：	1
19	Mechanical properties and microstructure of new magnesium-lithium base alloys显示文摘	SANSCHAGRIN A TREMBLAY R ANGERS R	1996	Mater Sci Eng(A)1996，220，12：	1
20	Ectopical and abnormalhormone receptors in adrenal Cushing,s syndrome显示文摘	Lacroix A Ndiaye N Tremblay J		Endocr Rev0，22，1：	1

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