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590篇 您的检索式：作者名="A W Moore"

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	题名	作者	年代	出处	被引量
1	Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation.	Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum	2010	World Journal of Gastroenterology2010，16，40：	23
2	显示文摘	GAYLOR D W MOORE J A	2004	Regulatory Toxicology and Pharmacology2004，39，：	1
3	Association between polysomnographic sleep measures and health-related quality of life in obstructive sleep apnea显示文摘	Moore P Bardwell W A Ancoli-Israel S	2001	J Sleep Res2001，10，4：	1
4	Gelation and clarification of concentrated orange juices I introduction and present status显示文摘	Wenzel F W Moore E L Rouse A H	1951	Food Technology1951，，5：	1
5	Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers显示文摘	Millar A W Brown PD Moore J	1998	Br J Clin Pharmacol1998，45，1：	1
6	Efficient applica- tion identification and the temporal and spatial stability of classification schema显示文摘	Li Wei Cannini M Moore A W	2009	Computer Networks2009，53，6：	1
7	Instructional adapta- tion in the management of escape-maintained behavior in a classroom 显示文摘	Moore D W Anderson A Kumar K	2005	Journal of Positive Behavior Interventions2005，，4：	1
8	Southern A frican topographyand erosion history: Plumes or plate tectonics-显示文摘	Moore A Blenkinsop T C otterill F W	2009	Terra Nova2009，21，4：	1
9	Egoism and independence:entrepreneurial ethics显示文摘	LONGENECKER J G MCKINNEY J A MOORE C W	1988	Organizational Dynamics1988，16，3：	1
10	Effects of the substrate to chamber wall distance on the structure and properties of CrAlN films deposited by pulsed-closed field unbalanced magnetron sputtering (P-CFUBMS) 显示文摘	L1N J MISHRA B MOORE J J SPROUL W D REES J A	2007	Surface and Coatings Technology2007，201，1617：	1
11	Reinforcement learning:a survey显示文摘	Kaelbling L P Littman M L Moore A W	1996	Journal of Artificial Intelligence Research1996，4，：	1
12	Accuracy of computational hemodynamics in complex arterial geometriesreconstrueted from magnetic resonance imaging显示文摘	MOORE J A STEINMAN D A HOLDSWORTH D W	1999	Annals of Biomedical Engineering1999，27，1：	1
13	Novel aspects of the insulin-like growth factor binding proteins显示文摘	Wetterau L A Moore M G Lee K W	1999	Mol Genet Metab1999，68，2：	1
14	MIC-1 isa novel TGF-beta superfamily cytokine associated with macro-phage activation显示文摘	FAIRLIE W D MOORE A G BAUSKIN A R	1999	J Leukoc Biol1999，65，1：	1
15	显示文摘	Spierings G A C M Dormans G J M Moors W G J	1997	J Appl Phys1997，78，：	1
16	A modified kolmogorov-smirnov test for weibull distribution with unknown location and scale parameters 显示文摘	Woodruff B W Moore A H Dunne E J	1983	IEEE Transaction on Reliability1983，32，2：	1
17	Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program 显示文摘	Moore W C Meyers D A Wenzel S E	2010	Am J Respir Crit Care Med2010，181，4：	1
18	Bacterialclearance and survival are dependent on CXC chemokine re- ceptor-2 ligands in a murine model of pulmonary Nocardia as- teroides infection 显示文摘	Moore T A Newstead M W Strieter R M	2000	J Immunol2000，164，2：	1
19	Crystal of ettringite 显示文摘	Moore A E Taylor H F W	1970	Acta Crystal1970，26，：	1
20	HOX genes in human lung: altered expression in primary pulmonary hypertension and em- physema显示文摘	Golpon H A Geraci M W Moore M D	2001	Am J Pathol2001，158，3：	1

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