|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 2 | Re-operation for the Treatment of well Differentiated Thyroid Cancer:Necessity,Safety and Impaction on Further Management显示文摘 | El-Zohairy M Zaher A | 2004 | J Egypt Natl Canc Inst2004，16，3： | 1 |
| 3 | The c-myc x E2F-1/p21 interactive gene expression index augments cytomorphologic diagnosis of lung cancer in fine-needle aspirate specimens显示文摘 | Crawford EL Zaher A | 2003 | J Mol Diagn2003，5，3： | 1 |
| 4 | Enantioselective addition of diethylzinc to aromatic aldehydes catalyzed by Ti (IV) complexes of Cz-symmetrical chiral BINOL derivatives 显示文摘 | Gou S H Zaher M A Judeh | 2008 | Tetrahedron Letters2008，50，： | 1 |
| 5 | On the design of chaos - based secure communication systems 显示文摘 | Zaher A A Abu - Rezq A | 2011 | Communications in Nonlinear Science and Numerical Simulation2011，16，9： | 1 |
| 6 | Circadi- an rhythm of stroke onset during the month of Ramadan 显示文摘 | E1-Mitwalli A Zaher AA E1 Menshawi E | 2010 | Acta Neurol Scand2010，122，2： | 1 |
| 7 | 显示文摘 | McCabe NP Angwafo FF Zaher A | 2000 | Oncol Rep2000，7，4： | 1 |
| 8 | Comparative studies on alkylation of phenol with tertbutyl alcohol in the presence of liquid or solid catalysts in ionil liquids显示文摘 | SHEN Hao - yu Zaher M A CHI Bun - ching XIA Qing - hua | 2004 | Journal of molecular catalysis A: chemcal2004，212，： | 1 |
| 9 | Human stromal (mesenchymal) stem cells: basic biology and current clinical use for tissue regeneration 显示文摘 | Aldahmash A Zaher W A1-Nbaheen M | 2012 | Ann Saudi Med2012，32，： | 1 |
| 10 | Relation between anemia and blood levels of lead, copper, zinc and ironamong children 显示文摘 | Hegazy A A Zaher M M El-hafez M A A | 2010 | BMC Research Note2010，3，1： | 1 |
| 11 | Nonlinear control of permanent magnet stepper motors显示文摘 | Harb Ahmad M Zaher Ashraf A | 2004 | Communications in Nonlinear Science and Numerical Simulation2004，，1： | 1 |
| 12 | Online wind turbine fault detection through automated SCADA data analysis 显示文摘 | ZAHER A MCARTHER S D J INFIELD D G | 2009 | Wind Energy2009，12，6： | 1 |
| 13 | Wind-powered electric water pumping system installed in a remote location显示文摘 | ZAHER A S RAO N R | 2000 | Applied Energy2000，65，： | 1 |
| 14 | Expression of soluble urkinase plasminogen activator may be related to outcome in prostate cancer patients显示文摘 | Mocabe NP Angwafo FF Zaher A | 2000 | Oncel Rep2000，7，4： | 1 |
| 15 | Online wind turbine fault detection through automated SCADA data analysis显示文摘 | Zaher A McArthur S D J Infield D G | 2009 | Wind Energy2009，12，： | 1 |
| 16 | Titanium complexes bearing bidentate benzimidazole containing ligands显示文摘 | Zaher D Tomov A K Gibson V C | 2008 | Journal of Organometallic Chemistry2008，693，26： | 1 |
| 17 | Online Wind Turbine Tautly Detection Through Automated SCADA Data Analysis显示文摘 | Zaher A McArther S D J Infield D G | | 0，，1095： | 1 |
| 18 | Expression of soluble urokinase plasminogen activator receptor may be related to outcome in prostate cancer patients显示文摘 | Mcabe NP Angwafo FF Zaher A | 2007 | Oncol Rep2007，7，4： | 1 |
| 19 | Parameter identification technique for uncertain chaotic systems using state feedback and steady-state analysis显示文摘 | Zaher A A | 2008 | Phys Rev E2008，77，03： | 1 |
| 20 | Impact of cyto- toxin-associated gene A of Helicobacter pylori strains on microalbuminuria in type 2 diabetes显示文摘 | Ibrahim A Zaher T Ghonemy TA | 2010 | Saudi J Kidney Dis Transpl2010，21，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员