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| 1 | Neoadjuvant therapy for pancreas cancer: Past lessons and future therapies显示文摘Pancreatic adenocarcinoma remains a most deadly malignancy, with an overall 5-year survival of 5%. A subset of patients will be diagnosed with potentially resectable disease, and while complete surgical resection provides the only chance at cure, data from trials of postoperative chemoradiation and/or chemotherapy demonstrate a modest survival advantage over those patients who undergo resection alone. As such, most practitioners believe that completion of multimodality therapy is the optimal treatment. However, the sequence of surgery, chemotherapy and radiation therapy is frequently debated, as patients may benefit from a neoadjuvant approach by initiating chemotherapy and/or chemoradiation prior to resection. Here we review the rationale for neoadjuvant therapy, which includes a higher rate of completion of multimodality therapy, minimizing the risk of unnecessary surgical resection for patients who develop early metastatic disease, improved surgical outcomes and the potential for longer overall survival. However, there are no prospective, randomized studies of the neoadjuvant approach compared to a surgeryfirst strategy; the established and ongoing investigations of neoadjuvant therapy for pancreatic cancer are discussed in detail. Lastly, as the future of therapeutic regimens is likely to entail patient-specific genetic and molecular analyses, and the treatment that is best applied based on those data, a review of clinically relevant biomarkers in pancreatic cancer is also presented. | Jeffrey M Sutton Daniel E Abbott | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | Implications of the temporal distribution of high-Mg magmas for mantle plume volcanism through time显示文摘 | ABBOTT D H | 2002 | Journal of Geology2002，110，： | 1 |
| 3 | Osmotic demyelination syndrome显示文摘 | Abbott R Silber E Felber J | 2005 | BMJ2005，331，7520： | 1 |
| 4 | Astrocyte-endothelial interactions at the blood-brain barrier显示文摘 | Abbott N J Ronnback L Hansson E | 2006 | Nat Rev Neurosci2006，7，： | 1 |
| 5 | Placental opioidenhancing factor(POEF):Generalizability of effects显示文摘 | ABBOTT P THOMPSON A C FERGUSON E J | 1991 | Physiology&behavior1991，50，： | 1 |
| 6 | Optimal information transmission in nonlinear arrays through suprathreshold stochastic resonance 显示文摘 | M D McDonnell N G Stocks C E M Pearce D Abbott | 2006 | Physics Letters A2006，352，3： | 1 |
| 7 | Bone mineral density thresholds for pharmacological intervention to prevent fractures显示文摘 | Siris E S Chen Y T Abbott T A | 2004 | Arch Intern Med2004，164，10： | 1 |
| 8 | Stochastic resonance and the data processing inequality 显示文摘 | M D McDonnell N G Stocks C E M Pearce D Abbott | 2003 | Electronics Letters2003，39，17： | 1 |
| 9 | An introduction to the European Hydrological System,'SHE',1:History and philosophy of a physically-based,distributed modeling system显示文摘 | Abbott M B Bathurst J C Cunge J A O'Connell P E Rasmussen J | 1986 | Journal of Hydrology1986，87，： | 1 |
| 10 | Surface-bonded antimicrobial activity of an organosilicon quaternary ammonium chloride显示文摘 | ISQUITH A J ABBOTT E A WALTERS P A | 1972 | Appl Environ Microbiol1972，24，6： | 1 |
| 11 | Genetic linkage mapping in peach using morphological,RFLP and RAPD markers显示文摘 | RAJAPAKSE S BELTHOFF L E HE G ESTAGER A E SCORZA R VERDE I BALLARD R E BAIRD W V CALLAHAN A MONET R ABBOTT A G | 1995 | Theor Appl Genet1995，90，： | 1 |
| 12 | A characterization of suprathreshold stochastic resonance in an array of comparators by correlation coefficient 显示文摘 | M D McDonnell D Abbott C E M Pearce | 2002 | Fluctuation and Noise Letters2002，2，3： | 1 |
| 13 | Alcoholic fermentation of carbon sources in biomass hydrolysates by Saccharomyces cerevisiae: current status显示文摘 | VAN MARIS A J A ABBOTT D A BELLISSIMI E | 2006 | Antonie Van Leeuwenhoek2006，90，4： | 1 |
| 14 | An introduction to the European Hydrological System,'SHE',2:Structure of a physically-based,distributed modeling system显示文摘 | Abbott M B Bathurst J C Cunge J A O'Connell P E Rasmussen J | 1986 | Journal of Hydrology1986，87，： | 1 |
| 15 | Resection of liver metastases from breast cancer: estrogen receptor status and re- sponse to chemotherapy prior to surgery define outcome显示文摘 | Abbott D E Brouquet A Mittendorf E A | 2012 | Sur gery2012，151，5： | 1 |
| 16 | Specifying surface quality:a method based on accurate measurement and comparison 显示文摘 | Abbott E J Firestone F A | 1933 | Mech Eng1933，55，： | 1 |
| 17 | Astrocyte-endothelial in- teractions at the blood-brain barrier 显示文摘 | Abbott NJ Ronnback L Hansson E | 2006 | Nat Rev Neurosci2006，7，1： | 1 |
| 18 | A comparison of the effects of ABA and an antitranspirant on chilling injury of coleus,cucumbers,and dieffenbaclua显示文摘 | SEMENIUK P MolineH E Abbott J A | 1986 | Journal of tbe American Society for Horticultural Science1986，111，： | 1 |
| 19 | Relative dating of Hawaiian lava flows using multispectral thermal infrared images a new tool for geologic mapping of young volcanic terranes显示文摘 | Gillespie A R Abbott E A | 1988 | Journ al of Geophysical Research1988，93，15： | 1 |
| 20 | Construction of saturated linkage maps of peach crosses segregating for characters controlling fruit quality, tree architecture andpest resistance显示文摘 | ABBOTT A G RAJAPAKSE S SOSINSKI B LU Z X SOSSEY- ALAOUI K GANNAVARPU M REIGHARD BALLARD R E BAIRD W V SCORZA R CALLAHAN A | 1998 | Aeta Horticulturae1998，465，： | 1 |
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