|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biogeochemistry inNeves Corvo mining region,Iberian Pyrite Belt,Portugal显示文摘 | Batista M J Abreu M M Serrano P M | 2007 | Journal of Geochemical Exploration2007，92，23： | 3 |
| 2 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 3 | Sequence stratigraphy of experimental strata under known conditions of differential subsidence and variable base level显示文摘 | Martin J Paola C Abreu V | 2009 | AAPG Bulletin2009，93，4： | 1 |
| 4 | Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and or paracrine substance显示文摘 | Carrillo-Vieo A Cairo JR Abreu P Lardone PJ Garcia-Maurino S Reiter R J | 2004 | FASEB J2004，18，3： | 1 |
| 5 | Effects of naloxone on opioid-induced hyperalgesia and tolerance to remifentanil under sevoflurane anesthesia in rats 显示文摘 | AGUADO D ABREU M BENITO J | 2013 | Anesthesiology2013，118，5： | 1 |
| 6 | Mineralogical characterization of the matrices of the primitive CR chondrites MET00426 and EErf99177 显示文摘 | Abreu N M Brearley A J | 2005 | Meteoritics & Planetary Science2005，40，： | 1 |
| 7 | Towards the standardization of sequence stratigraphy显示文摘 | Catuneanu O Abreu V Bhattacharya J P | 2009 | Earth-Science Reviews2009，9，： | 1 |
| 8 | Satured hydraulic conductivity of soil in the Southern Piedmont of Georgia, USA: Field evaluation and relation to horizon and landscape properties显示文摘 | West L T Abreu M A Bishop J P | 2008 | Catena2008，73，： | 1 |
| 9 | An evidence-based systematic review on medical therapies for inflammatory bowel disease显示文摘 | TALLEY N J ABREU M T ACHKAR J P | | 0，，： | 1 |
| 10 | The use of PCR-RFLP to genetically distinguish the morphologically close species: Ceriodaphnia dubia Richard, 1894 and Ceriodaphnia silvestrii Daday, 1902 (Crustacea Cladocera)显示文摘 | ABREU M J SANTOS-WISNIEWSKI M J ROCHA O | 2010 | Brazilian Journal Biology2010，70，1： | 1 |
| 11 | Shaping the detection lobe of ultrasonic ranging devices 显示文摘 | ABREU M J M | 1997 | Measurement Science Technology1997，8，11： | 1 |
| 12 | Use of a warm mix asphalt additive to reduce the production temperatures and to improve the performance of asphalt rubber mixtures显示文摘 | OLIVEIRA J R M SILVA H M R D ABREU L P F | 2013 | Journal of Cleaner Production2013，41，： | 1 |
| 13 | CVD diamond coated silicon nitride self-mated systems:Tribological behaviour under high loads显示文摘 | Abreu C S Oliveira F J Belmonte M | 2006 | Tribology Lett2006，21，2： | 1 |
| 14 | Effects of naloxone on opioid-induced hyperalgesia and tolerance to remifentanil under sevoflurane anesthesia in rats显示文摘 | Aguado D Abreu M Benito J | 2013 | Anesthesiology2013，118，5： | 1 |
| 15 | Joule heating at high latitudes显示文摘 | Foster J C St-Maurice J P Abreu V J | 1983 | Journal of Geophysical Research1983，88，6： | 1 |
| 16 | Towards the standardization of sequence stratigraphy显示文摘 | Catuneanu O Abreu V Bhattacharya J P | 2009 | Earth-Science Reviews2009，92，： | 1 |
| 17 | Cryopre- servation of some useful microalgae species for biotech- nological exploitation显示文摘 | ABREU L BORGES L MARANGONI J | 2012 | Journal of Applied Phycology2012，24，6： | 1 |
| 18 | Chemical composition,D M and NDF degradation kinetics in rumen of seven legume straws显示文摘 | Bruno-Soares A M Abreu J M F | 2000 | Animal Feed science and Technology2000，，83： | 1 |
| 19 | Grazing protozoaand magnetosome dissolution in magnetotactic bacteria显示文摘 | Martins J L Silveira T S Abreu F | 2007 | Environmental Microbiology2007，9，11： | 1 |
| 20 | The Arabidopsis E3 SUMO ligase SIZ1 regulates plant growth and drought responses显示文摘 | Catalá R Ouyang J Abreu IA Hu Y Seo H Zhang X Chua NH | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员