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| 1 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 2 | Outcome of cytomegalovirus infections in patients with inflammatory bowel disease显示文摘 | Konstantinos A Papadakis Jim K Tung Scott W Binder Lori Y Kam Maria T Abreu Stephan R Targan Eric A Vasiliauskas | 2001 | The American Journal of Gastroenterology2001，，7： | 2 |
| 3 | Satured hydraulic conductivity of soil in the Southern Piedmont of Georgia, USA: Field evaluation and relation to horizon and landscape properties显示文摘 | West L T Abreu M A Bishop J P | 2008 | Catena2008，73，： | 1 |
| 4 | An evidence-based systematic review on medical therapies for inflammatory bowel disease显示文摘 | TALLEY N J ABREU M T ACHKAR J P | | 0，，： | 1 |
| 5 | Grazing protozoaand magnetosome dissolution in magnetotactic bacteria显示文摘 | Martins J L Silveira T S Abreu F | 2007 | Environmental Microbiology2007，9，11： | 1 |
| 6 | Decreased expression of Toll-like receptor-4 and MD-2correlates with intestinal epithelial cell protection againstdysregulated proinflammatory gene expression in responseto bacterial,lipopolysaccharide 显示文摘 | Maria T Abreu Puja Vora Emmanuelle Faure | 2001 | J Exp Med2001，167，3： | 1 |
| 7 | Oxidative stress and acute lung injury 显示文摘 | Chow CW Abreu MTH Suzuki T | 2003 | Am J Respir Cell Mol Biol2003，29，4： | 1 |
| 8 | A pilot study to evalu ate the safety and feasibility of the administration of AZT/3TC fixed dose combination to HIV infected pregnant women and their infants in Rio de Janeiro, Brazil显示文摘 | Lambert JS Nogueira SA Abreu T | 2003 | Sex Transm Infect2003，79，6： | 1 |
| 9 | Oxidative stress and acute lung injury显示文摘 | Chow C W Abreu M T H Suzuki T | 2003 | Am J Respir Cell Mol Bio12003，29，4： | 1 |
| 10 | Adaptive gating for multitarget tracking with Gaussian mixture filters显示文摘 | Macagnano D de Abreu G T F | 2012 | IEEE Transactions on Signal Processing2012，60，3： | 1 |
| 11 | Simulated soil vapor intrusion attenuation factors including biodegradation for petroleum显示文摘 | ABREU L D ETTINGER R MCALARY T | 2009 | Ground Water Monitoring - Remediation2009，29，1： | 1 |
| 12 | Innate immunity and toll-like receptors: clinical implication of basic research 显示文摘 | Abreu M T Arditi M | 2004 | Pediatric2004，144，： | 1 |
| 13 | Adaptive gating for multitarget tracking with Gaussian mixture filters显示文摘 | Macagnano D Freitas de Abreu G T | | 0，，03： | 1 |
| 14 | Moderately thermophilic magnetotactic bacteria from hot springs in Nevada显示文摘 | LEFEVRE C T ABREU F SCHMIDT M L | 2010 | App Environ Microbiol2010，76，11： | 1 |
| 15 | TLR signaling in the gut in health and disease显示文摘 | Abreu M T Fukata M Arditi M | 2005 | J Immunol2005，174，： | 1 |
| 16 | Oxidative stress and acute lunginjury显示文摘 | Chow C W Abreu M T H Suzuki T | 2003 | AmJ Respir Cell Mol Biol2003，29，4： | 1 |
| 17 | Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function显示文摘 | ABREU M T | 2010 | Nat Rev Immunol2010，10，2： | 1 |
| 18 | Degradation kinetics of colour, vitamin C and drip loss in frozen broccoli (Brassica oleracea L ssp Italica) during storage at isothermal and non-isothermal conditions 显示文摘 | Gongalves E M Abreu M Brandao T R S | 2011 | International Journal of Refrigeration2011，34，8： | 1 |
| 19 | Regulation of immune responses of intestinal mucosa显示文摘 | Marla T Abreu M Tephan R T | 1996 | Crit Rev Immun1996，16，： | 1 |
| 20 | A review on relation extraction with an eye on Portuguese显示文摘 | Abreu S C Bonamigo T L Vieira R | 2013 | Journal of the Brazilian Computer Society2013，19，4： | 1 |
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