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| 1 | Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis显示文摘AIM To assess differences in clinical outcomes of isolated renal failure(RF) compared to other forms of organ failure(OF) in patients with severe acute pancreatitis(SAP).METHODS Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ(2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ~2 test for discrete variables.RESULTS Among 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75(67.6%) were male. Forty-three patients had isolated OF: 17(15.3%) renal, 25(21.6%) respiratory, and 1(0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support(76.5% vs 96%, P = 0.001), ICU admission(58.8% vs 100%, P = 0.001), and had shorter mean ICU stay(2.4 d vs 15.7 d, P < 0.001), compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died.CONCLUSION Among patients with SAP per the Revised Atlanta Classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis. | Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka David C Whitcomb Dhiraj Yadav Georgios I Papachristou | 2017 | World Journal of Gastroenterology2017，23，29： | 20 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Activation tagging identifies a gene from Petunia hybrida responsible for the production of active cytokinins in plants 显示文摘 | ZUBKO E ADAMS C J MACHAEKOVA I | 2002 | Plant J2002，29，6： | 1 |
| 4 | Short - channel effects and drain - induced barrier lowering in nanometerscale GaAs MESFET's 显示文摘 | James A Adams Thayne I G Wilkinson C D W | 1993 | IEEE Trans Electron Devices1993，40，6： | 1 |
| 5 | Ion channels and membrane rafts in apoptosis显示文摘 | Szabò I Adams C Gulbins E | 2004 | Pflugers Arch2004，448，3： | 1 |
| 6 | Prospective randomized construed trial of an intramedullary nai! versus dy- namic screw and plate for intertrocbanteric fractures of the femur 显示文摘 | Adams C I Robinson C M Court-Brown C M | 2001 | J orthop Trauma2001，15，： | 1 |
| 7 | Developing sustainability criteria for urban infrastructure systems 显示文摘 | Sahely H R Kennedy C A Adams B I | 2005 | Canadian Journal of Civil Engineering2005，32，1： | 1 |
| 8 | Activation tagging identifies a gene from Petunia hybrida responsible for the production of active cytokinins in plants显示文摘 | ZUBKO E ADAMS C J MACH(A)(C)KOV(A) I | 2002 | Plant J2002，29，： | 1 |
| 9 | The uplift capacity of shallow foundations显示文摘 | ADAMS J I HAYES U C | 1967 | Ontario Hydro Research Quarterly1967，19，1： | 1 |
| 10 | Deleterious ef- fect of extended cold ischemia time on the posttransplant outcome of aged livers显示文摘 | Adam R Sanchez C Astarcioglu I | 1995 | Transplant Proc1995，27，1： | 1 |
| 11 | Fetal growth restric-tion: adaptations and consequences 显示文摘 | McMIIXEN I C ADAMS M B ROSS J T | 2001 | J Reproduction2001，122，： | 1 |
| 12 | Seasonal changes in the diet composition and prey selection of walleye pollock ( Theragra chalcogramma ) in the northern Gulf of Alaska 显示文摘 | Adams C F Pinchuk A I Coyle K O | 2007 | Fisheries Research2007，84，3： | 1 |
| 13 | Fetal growth restriction, adaptations and consequences显示文摘 | McMillen I C Coulter C L Adams M B | 2001 | Reproduction2001，122，： | 1 |
| 14 | Prospec- tiverandomized controlled trial of an intramedullary nail versusdy- namic screw and plant for introchanteric fracture of the femur显示文摘 | Adams C I Robinson C M Court- Brown C M | 2001 | J Orthop Trauma2001，15，： | 1 |
| 15 | Gupta,Triterpenes and fatty acids from Discophora guianensis identified by GC-MS显示文摘 | ANGELA I C ADAM H EVISABEL C | 2013 | Biochemical Systematics and Ecology2013，50，10： | 1 |
| 16 | On the pathogenesis of focal nodular hyperplasia of the liver显示文摘 | Wanless I Mawdsley C Adams R | 1985 | Hepatology1985，5，： | 1 |
| 17 | The ultimate uplift capacity of foundations显示文摘 | MEYERHOF G C~ ADAMS J I | 1968 | Canadian Geotechnical Journal1968，5，4： | 1 |
| 18 | The uplift capacity of shallow foundations显示文摘 | ADAMS J I HAYES U C | 1967 | Ontario Hydro Research Quarterly1967，19，1： | 1 |
| 19 | Activation tagging identifies a gene from Petunia hybrida responsible for the production of active cytokinins in plants 显示文摘 | Zubko E Adams C J Machaekova I et aI | 2002 | Plant Journal2002，29，： | 1 |
| 20 | Prospective randomized controlled trial of an intramedullary nail versus dynamic screw and plate for intertrochanteric fractures of the femur显示文摘 | Adams C I Robinson C M Court Brown C M | 2001 | J Orthop Trauma2001，15，6： | 1 |
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