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| 1 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 2 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 3 | Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn’s Disease显示文摘 | Pierre Desreumaux Arnaud Foussat Matthieu Allez Laurent Beaugerie Xavier Hébuterne Yoram Bouhnik Maria Nachury Valérie Brun Hervé Bastian Nathalie Belmonte Michel Ticchioni Agnès Duchange Patricia Morel–Mandrino Virginie Neveu Nathalie Clerget–Chossat Mig | 2012 | Gastroenterology2012，，5： | 4 |
| 4 | Measurements of rf bias effect in a dual electron cyclotron resonance-rf methane plasma using the langmuir probe method 显示文摘 | Junegie H Agnes G Christian L | 2000 | J Vac Sci Technol2000，18，2： | 1 |
| 5 | Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populalions显示文摘 | Koustubh R Agnes C H Kwan Dun W | 2000 | Am J Hypertens2000，13，70： | 1 |
| 6 | Determination of the Distribution of Elements as a Function of Particle Size in Aerosol Samples by Sequential Leaching显示文摘 | Jozsef H Lavay Klara Polyak Agnes Molnar | 1998 | Analyst1998，123，： | 1 |
| 7 | as the polar phase in low-temperature-stable-microemulsion 显示文摘 | Agnes H Oliver Z Robert H | 2011 | Langmuir2011，27，5： | 1 |
| 8 | Toxicology of carbon nanomaterials:Status,trends,and perspectives on the special issue显示文摘 | Robert H H Marc M Agnes K | 2006 | Carbon2006，44，6： | 1 |
| 9 | Cell culture propaga- tion of porcine rotavirus (reovirus-like agent) 显示文摘 | THEIL K W BOHL E H AGNES A G | 1977 | Am J Vet Res1977，38，11： | 1 |
| 10 | Phage pattem and antibiotic resistance pattern of coagulase negative staphylococci obtained from immuno compromised patient显示文摘 | Istvan B Agnes H Andras L | 1992 | Microbiol Immunol1992，36，9： | 1 |
| 11 | Environmental Impacts of the Yangtze Three Gorges Project: An Overview of the Chinese-German Research Cooperation显示文摘The construction of the Three Gorges Dam on the Yangtze River in China has a great influence on the ecosystems involved. In order to investigate these environmental effects in the Yangtze catchment area as well as downstream of the dam, Forschungszentrum Jülich has organized a research network for the Chinese and German partners. In the research fields of (1) interaction water/ sediment/contaminants, (2) vegetation/biodiversity, (3) changing land use/erosion/mass movements, and (4) atmosphere, the partners have accumulated a great deal of expertise in handling major issues and also in developing models and recommendations for action. The following provides an overview of the research network and the research tasks. On the German side, five projects in research field (3) have been in operation since 2008. The results are reported in contributions by Ehret et al., Jaehnig and Cai, Schnbrodt et al., and Seeber et al.. Another five projects in research field (1) have started by September 2010. The research tasks undertaken in these five projects are presented below. | Günter Subklew Julia Ulrich Leander Fürst Agnes Hltkemeier | 2010 | Journal of Earth Science2010，21，6： | 1 |
| 12 | Influence of temperature on rate of regeneration in the time-graded regeneration field in planarians显示文摘 | AGNES BRNDSTED H V | 1961 | J Embryol Exp Morph1961，9，： | 1 |
| 13 | How we diagnosis and treat deep vein thrombosis显示文摘 | JACK H AGNES Y | 2002 | Blood2002，99，： | 1 |
| 14 | Health effects of quer- cetin: from antioxidant to nutraceutical 显示文摘 | AGNES W B GUIDO R H ALAT B | 2008 | European Jour- nal of Pharmacology2008，585，23： | 1 |
| 15 | ZnAl-layer double hydroxides as photocatalysts for oxidation of phenol in aqueous solution显示文摘 | Agnes P Robert K Viktoria H | | 0，，： | 1 |
| 16 | Cell culture propagation of porcine rotavirus(reovirus-like agent)显示文摘 | TheilK W Bohl E H Agnes A G | | 0，，： | 1 |
| 17 | Diagenesis,porosity evolution,and petroleum emplacement in tight gas reservoirs,Taranaki Basin,New Zealand显示文摘 | Karen E H Horst Z Agnes G R | | 0，，12： | 1 |
| 18 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | 2013 (9908)2013，，9908： | 1 |
| 19 | Efficacy and Safety of the Ahmed glaucoma valve implant in Chinese eyes with complicated glaucoma显示文摘 | JIMMY S M AGNES S Y JOHN K H | 2000 | Br J Ophthalmol2000，84，2： | 1 |
| 20 | Determination of the distribution of elements as a function of particle size in aerosol samples by sequential leaching显示文摘 | Lavay Jozsef H Polyak Klara Molnar Agnes | 1998 | Analyst1998，123，： | 1 |
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