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| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants显示文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial(DFM) can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria(LAB), lactic acid utilizing bacteria(LUB), or other microorganism's species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance. | Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán | 2015 | Journal of Integrative Agriculture2015，14，3： | 7 |
| 3 | Biological treatments as a mean to improve feed utilization in agriculture animals——An overview显示文摘As a result of agriculture practices, million tons of agriculture are produced as a secondary or by-products; however, with low nutritive values. Many methods are applied to improve the nutritive value and increase its utilization in ruminant's nutrition. The biological treatments are the most common with more safe-treated products. In most cases, the biological treatments are paralleled with decreased crude fiber and fiber fractions content with increased crude protein content. Direct-fed microbial and exogenous enzymes to animal are other ways of biological methods for improving nutritive value of feeds. Here in this review, we will try to cover the biological treatments of by-products from different sides view with different types of animals and different animal end-products. | Nahla A Abdel-Aziz Abdelfattah Z M Salem Mounir M El-Adawy Luis M Camacho Ahmed E Kholif Mona M Y Elghandour Borhami E Borhami | 2015 | Journal of Integrative Agriculture2015，14，3： | 4 |
| 4 | Fulminant hepatic failure caused by Salmonella paratyphi A infection显示文摘我们报导暴发性的肝的失败的一个案例把感染与沙门氏菌 paratyphi 联系了,在进入有二天的发烧的特别护理单位(ICU ) 的一个 29 岁的病人,头疼并且呕吐列在后面由行为变化和丧失方向感。在检查上,病人显得尖锐地病了,鼓动,糊涂,并且深深地 jaundiced。C 的温度 38.5 度,脉搏 92/min,血压 130/89 毫米汞柱。血的两件样品种了 S。paratyphi A,它对 ceftriaxone 和 ciprofloxacin 敏感。Ceftriaxon 与高剂量的地塞米松被管理。有 ceftriaxon 的二星期术后疗法,病人处于令人满意的状况被解除。 | Fahmi Yousef Khan Ahmed A Kamha Ibrahim Y Alomary | 2006 | World Journal of Gastroenterology2006，12，32： | 3 |
| 5 | Mapping of three QTLs for seed setting and analysis on the candidate gene for qSS-1 in rice(Oryza sativa L.)显示文摘The lower seed setting is one of the major hindrances which face grain yield in rice.One of the main reasons to cause low spikelet fertility(seed setting)is male sterility or pollen abortion.Notably,pollen abortion has been frequently observed in advanced progenies of rice.In the present study,149 BC_2F_6 individuals with significant segregation in spikelet fertility were generated from the cross between N040212(indica)and Nipponbare(japonica)and used for primary gene mapping.Three QTLs,qSS-1,qSS-7 and qSS-9 at chromosomes 1,7 and 9,respectively,were found to be associated with seed setting.The recombinant analysis and the physical mapping information from publicly available resources exhibited that the qSS-1,qSS-7 and qSS-9 loci were mapped to an interval of 188,701 and 3741 kb,respectively.The seed setting responsible for QTL qSS-1 was further fine mapped to 93.5 kb by using BC_2F_7 population of 1 849 individuals.There are 16possible putative genes in this 93.5 kb region.Pollen vitality tests and artificial pollination indicated that the male gamete has abnormal pollen while the female gamete was normal.These data showed that low seed setting rate relative to qSS-1may be caused by abnormal pollen grains.These results will be useful for cloning,functional analysis of the target gene governing spikelet fertility(seed setting)and understanding the genetic bases of pollen sterility. | Elsheikh Y M Ahmed ZHANG Yan-pei YU Jian-ping Rashid M A Rehman ZHANG Zhan-ying ZHANG Hong-liang LI Jin-jie LI Zi-chao | 2016 | Journal of Integrative Agriculture2016，15，4： | 2 |
| 6 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 7 | Coating of calcia-doped ce- ria with amorphous silica shell by seeded polymerization technique 显示文摘 | Ahmed M Shu Y ~abe S Sato T | 2005 | Materials Research Bulletin2005，40，： | 1 |
| 8 | Hysterosalpingo-contr-ast sonography versus radiographic hysterosalping-ographyin the evaluation of tubal patency显示文摘 | Hossam O Ahmed Y Shahin | 2009 | Int J Gynecol Obstet2009，105，3： | 1 |
| 9 | Synthesis of manganese ferrite from non-standard raw materials using ceramic technique 显示文摘 | AHMED Y M Z | 2010 | Ceramics International2010，36，3： | 1 |
| 10 | Purification and partial characterization of milk-clotting enzyme extracted from glutinous rice wine mash liquor显示文摘 | WANG Y CHENG Q AHMED Z | 2009 | Korean Journal of Chemical Engineering2009，26，5： | 1 |
| 11 | Purification and partial characterization of milk-clotting enzyme extracted from glutinous rice wine mash liquor 显示文摘 | WANG Y CHENG Q AHMED Z ct al | 2009 | Korean J Chem Eng2009，26，5： | 1 |
| 12 | Host plants and natural enemies of Bemisia tabaci (Homoptera:Aleyrodidae) in China显示文摘 | LiS J Xue X Ahmed M Z Ren S X Du Y Z Wu J H Cuthbertson A G S and Qiu B L | | 0，，： | 1 |
| 13 | Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NFrd3- mediated induction of MMP2显示文摘 | Bilandzic M Wang Y Ahmed N | 2014 | Cancer letters2014，354，1： | 1 |
| 14 | Hydrocracking deasphalted oil from an atmospheric residuum显示文摘 | Ahmed H S El-kady F Y | 2008 | Energy Sources2008，30，3： | 1 |
| 15 | Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to in- creased apoptosis induced by chemotherapeutic agents in human cancer cells 显示文摘 | Li Y Ahmed F Ali S | 2005 | Cancer Res2005，65，15： | 1 |
| 16 | Endochondral ossifica-tion:how cartilage is converted into bone in the developing skeleton显示文摘 | Mackie E J Ahmed Y A Tatarczuch L | 2008 | Int J Biochem Cell Biol2008，40，1： | 1 |
| 17 | Application of He's semi-inverse method to the nonlinear Schr6dinger equatlon显示文摘 | TURO AHM Y | 2007 | Compu Math Appl2007，54，78： | 1 |
| 18 | NURBS skinning surface for ship hull design based on new parameterization method显示文摘 | SHAMSUDDIN S M AHMED M A SAMIAN Y | 2006 | Int J Adv Manuf Technol2006，28，： | 1 |
| 19 | Draxin Inhibits Axonal Out- growth through the Netrin Receptor DCC显示文摘 | Ahmed G Shinmyo Y Ohta K | 2011 | J Neuresci2011，31，14： | 1 |
| 20 | A recursive PLS-based soft sensor for prediction of the melt index during grade change operations in HDPE plant显示文摘 | Ahmed F Nazier S Yeo Y K | 2009 | The Korean Journal of Chemical Engineering2009，26，1： | 1 |
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