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| 1 | Sleep,immunity and inflammation in gastrointestinal disorders显示文摘Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research endeavors.An estimated 70 million Americans suffer from some form of sleep disorder.Certain sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance detriments.Recent research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause mortality.Several research studies support the associations among sleep,immune function and inflammation.Here,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal disorders.Different physiologic processes including immune system and inflammatory cytokines help regulate the sleep.The inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep disturbances.On the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory cytokines.Alterations in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal cancer.In turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal diseases.Knowledge of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients. | Tauseef Ali James Choe Ahmed Awab Theodore L Wagener William C Orr | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 3 | Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy显示文摘AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible bronchoscopy.METHODS A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were reviewed.RESULTS Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. Children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of hypoxemia.CONCLUSION Children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers. | Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed Elizabeth A S Moser Renee C McKinney Riad Lutfi | 2017 | World Journal of Critical Care Medicine2017，6，4： | 8 |
| 4 | Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants显示文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial(DFM) can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria(LAB), lactic acid utilizing bacteria(LUB), or other microorganism's species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance. | Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán | 2015 | Journal of Integrative Agriculture2015，14，3： | 7 |
| 5 | Mixed epithelial endocrine neoplasms of the colon and rectum–An evolution over time:A systematic review显示文摘BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms.These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally.Though they have been a well-documented entity in the pancreas,where the exocrine-endocrine mixed tumors have been known for a while,recognition and accurate diagnosis of these tumors in the colon and rectum,to date,remains a challenge.This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification.Therefore,dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers.Though,most of these tumors are high grade and of advanced stage,intermediate and low grade lesions of these mixed tumors are also increasingly been reported.There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions.AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape,clinicoradiological features,pathology,treatment,prognosis,the current status of the management of the primary lesions,their recurrences and metastases.METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed,MEDLINE and GOOGLE scholar.The following search terms[“mixed tumors colon”OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors]were used.Eligibility criteria were defined and all potential relevant items,including full articles and/or abstracts were independently reviewed,assessed and agreed upon items were selected for in-depth analysis.RESULTS In total 237 full articles/abstracts documents were considered for eligibility of which 45 articles were illegible resulting in a total of 192 articles that were assessed for eligibility of which 139 have been selected for reference in this current review.This seminal manuscript is a one stop article that provides a detailed outlook on the evolution over time with summarization of historical perspectives,nomenclature,clinicoradiological features,pathology,treatment,prognosis and the current status of the management of both the primary lesions,their recurrences and metastases.Gaps in knowledge have also been identified and discussed.An important outcome of this manuscript is the justified proposal for a new,simple,clinically relevant,non-ambiguous terminology for these lesions to be referred to as mixed epithelial endocrine neoplasms(MEENs).CONCLUSION MEEN of the colon and rectum are poorly understood rare entities that encompass an extensive range of heterogeneous tumors with a wide variety of combinations leading to tumors of high,intermediate or low grade malignant potential.This proposed new revised terminology of MEEN will solve the biggest hurdle of confusion and misclassification that plagues these rare unique colorectal neoplasms thus facilitating the future design of multi institutional prospective randomized controlled clinical trials to develop and evaluate newer therapeutic strategies that are recommended for continued improved understanding and personal optimization of clinical management of these unique colorectal neoplasms. | Rani Kanthan Suresh Tharmaradinam Tehmina Asif Shahid Ahmed Selliah C Kanthan | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 6 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 7 | Dynamic capabilities: A review and research agenda显示文摘 | WANG C L AHMED P K | 2007 | International Journal of Management Reviews2007，9，1： | 1 |
| 8 | Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2+ influx显示文摘 | Jho D Mehta D Ahmmed G Gao XP Tiruppathi C Broman M | 2005 | Circ Res2005，96，12： | 1 |
| 9 | Early detection of viral resista rice by determination of hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic hepatitis B 显示文摘 | Ahmed SNS Tavan D Pichoud C | 2000 | Hepatology2000，32，5： | 1 |
| 10 | Electrochemical oxidation of textile wastewater and its reuse显示文摘 | Mohana N Balasubramanianb N Ahmed Bashab C | 2007 | Journal of Hazardous Materials2007，147，12： | 1 |
| 11 | Dynamic capabilities: A Review and Research Agenda 显示文摘 | Wang C L Ahmed P K | 2007 | International Journal of Management Reviews2007，，9： | 1 |
| 12 | 查看详情显示文摘 | Pa N F C Ahmed I Nawawi M G M Rahman W A W A | | 0，，04： | 1 |
| 13 | Survey on energy harvesting wireless communications: Challenges and opportunities for radio resource allocation显示文摘 | Ahmed I Butt M M Psomas C | 2015 | Computer Networks2015，88，8： | 1 |
| 14 | BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AMLblasts显示文摘 | Kohl T M Hellinger C Ahmed F | 2007 | Leukemia2007，21，8： | 1 |
| 15 | Indirect electrochemical oxidation of p-methoxy-toluene to p-methoxy-benzaldehyde using ceric methanesulphonate: a scale-up study 显示文摘 | Devadoss V Ahmed Basha C Jayaraman K | 2008 | Ind Eng Chem Res2008，47，14： | 1 |
| 16 | Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non- alcoholic fatty liver disease (NAFLD) 显示文摘 | Ahmed M H Byrne C D | 2007 | Dru Discov Today2007，12，17： | 1 |
| 17 | Immune alterations and emerging immunotherapeutie approaches in lung cancer显示文摘 | Dasanu C A Sethi N Ahmed N | 2012 | Expert Opin Biol Ther2012，12，7： | 1 |
| 18 | Novel benzothiazole-2- carbomates as potential anthelmintieagents显示文摘 | Omar A M M E Ahmed I C | 2007 | Alexandria J of Pharm Scien2007，21，2： | 1 |
| 19 | Evaluation of induction of systemic resistance in pepper plants (Capsicum annum) to Phytophtora capsici using Trichoderma harzianum and its relation with capsidiol accumulation 显示文摘 | Perez S C Emilia C M | 2000 | European Journal of Plant Pathology2000，106，9： | 1 |
| 20 | Correlated binocular activity guides recovery from monocular deprivation显示文摘 | KIND P C MITCHELL D E AHMED B | 2002 | Nature2002，416，6879： | 1 |
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