|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 3 | 老年男性勃起功能及迟发性性腺功能减退症状与下尿路症状严重性的关系显示文摘本文旨在研究土耳其爱琴海地区的老年男性下尿路症状(LUTSs)、勃起功能障碍(ED)和有症状的迟发性性腺功能减退症(SLOH)三者间的关系。符合以下标准的500名男性患者被纳入该研究:40周岁以上;过去6个月内有稳定的性关系;在六个泌尿外科诊所之一进行过就诊登记。每位患者均行血清PSA、睾酮水平及尿流率的检测,并填写国际前列腺症状评分和生活质量评分(IPSS-QoL)量表、国际勃起功能指数(IIEF)问卷和老年男性症状(AMS)量表。在所有的研究对象中,23.9%的患者有轻度LUTSs,53.3%有中度LUTSS,22.8%有重度LUTSS。每组间总睾酮水平无明显差异。除此之外,69.6%的病人患有ED,且ED的发生率与LUTS严重性呈正相关。71.2%的患者出现SLOH(AMS〉27),且IPSS评分越高,严重的性腺功能减退症状的发生率也越高。相关性分析显示以上三种问卷分数之间有显著关联。总之,LUTS严重性是ED和SLOH的非年龄依赖性危险因素,LUTS严重性和SLOH症状之间似乎有显著的相关性,但还需要从病因学和生物学角度进行深入阐明。 | Ozan Bozkurt Deniz Bolat Omer Demir Oktay Ucer Ali Sahin Burak Ozcift Abdulkadir Pekta Tahir Turan Bilal H Gümü Ertan Cans Ahmet Bolukbasi Haluk Erol Adil Esenx | 2013 | Asian Journal of Andrology2013，15，6： | 4 |
| 4 | Investigation of soliton solutions with different wave structures to the(2+1)-dimensional Heisenberg ferromagnetic spin chain equation显示文摘The principal objective of this article is to construct new and further exact soliton solutions of the(2+1)-dimensional Heisenberg ferromagnetic spin chain equation which investigates the nonlinear dynamics of magnets and explains their ordering in ferromagnetic materials.These solutions are exerted via the new extended FAN sub-equation method.We successfully obtain dark,bright,combined bright-dark,combined dark-singular,periodic,periodic singular,and elliptic wave solutions to this equation which are interesting classes of nonlinear excitation presenting spin dynamics in classical and semi-classical continuum Heisenberg systems.3D figures are illustrated under an appropriate selection of parameters.The applied technique is suitable to be used in gaining the exact solutions of most nonlinear partial/fractional differential equations which appear in complex phenomena. | M S Osman K U Tariq Ahmet Bekir A Elmoasry Nasser S Elazab M Younis Mahmoud Abdel-Aty | 2020 | Communications in Theoretical Physics2020，72，3： | 4 |
| 5 | Biepicondylar fracture dislocation of the elbow joint concomitant with ulnar nerve injury显示文摘In this article, we present a case of humeral biepicondylar fracture dislocation concomitant with ulnar nerve injury in a seventeen year-old male patient. Physical examination of our patient in the emergency room revealed a painful, edematous and deformed-looking left elbow joint. Hypoesthesia of the little finger was also diagnosed on the left hand. Radiological assessment ended up with a posterior fracture dislocation of the elbow joint accompanied by intra-articular loose bodies. Open reduction-Internal fixation of the fracture dislocation and ulnar nerve exploration were performed under general anesthesia at the same session as surgical treatment of our patient. Physical therapy and rehabilitation protocol was implemented at the end of two weeks post-operatively. Union of the fracture lines, as well as the olecranon osteotomy site, was achieved at the end of four months post-operatively. Ulnar nerve function was fully restored without any sensory or motor loss. Range of motion at the elbow joint was 20-120 degrees at the latest follow-up. | M Nuri Konya Ahmet Aslan Hakan Sofu Timur Y?ld?r?m | 2013 | World Journal of Orthopedics2013，4，2： | 2 |
| 6 | The Effects of Austempering Temperature and Time on the Machinability of Vermicular Graphite Iron 显示文摘 | Ahmet M Ihsan K | 2014 | Materialpruefung : Werkstoffe und Bauteile Forschung Prufung Anwendung2014，56，4： | 1 |
| 7 | Exhibit enhanced hepatitis after concanavalin a injection:evidence for involvement of CD44 in activation-induced cell death显示文摘 | Chen D Robert J M Ahmet Z | 2001 | J Immunol2001，166，： | 1 |
| 8 | A novel neutral point potential stabilization technique using the information of output current polarities and voltage vector显示文摘 | Katsutoshi Yamanaka Ahmet M Hava | | 0，，06： | 1 |
| 9 | Elastoplastic contact/impact of rigidly supported composites显示文摘 | Majeed M A Ahmet S Y Andreas P C | 2012 | Composites Part B:Engineering2012，43，3： | 1 |
| 10 | An SVD-based grayscale image quality measure for local and global assessment显示文摘 | Aleksandr Shnayderman Alexander Gusev Ahmet M Es- kicioglu | 2006 | IEEE Transactions on Image Processing2006，15，2： | 1 |
| 11 | A Near-state PWM Method With Reduced Switching Losses and Reduced Common-mode Voltage for Three-phase Voltage Source Inverters显示文摘 | Emre Un Ahmet M Hava | | 0，，02： | 1 |
| 12 | The catalytic role of transition meta salts on supercritical water oxidation of phenol and chloroprene in a titanium reactor显示文摘 | Ahmet M Gizira Anthony Clifford | 2003 | Applied Catalysis2003，78，1： | 1 |
| 13 | Separation of trace antimony and arsenic prior to hydride generation atomic absorption spectrometric determination显示文摘 | MüSEEREF YERSEL ASL1 ERDEM AHMET E EROGLU | 2005 | Analytica Chimica Acta2005，，534： | 1 |
| 14 | A High Performance PWM Algorithm for Common-mode Voltage Reduction in Threephase Voltage Source Inverters显示文摘 | Ahmet M Hava Emre Un | | 0，，07： | 1 |
| 15 | The comparative effects of valsartan and amlodipine on v Wf levels and N/L ratio in patients with newly diagnosed hypertension显示文摘 | Karaman M Balta S Seyit Ahmet AY | 2013 | Clin Exp Hypertens2013，35，7： | 1 |
| 16 | Study of non-uniform bedding due to voids under jointed PVC water distribution pipes显示文摘 | Müge Balkaya Ian D. Moore Ahmet Sa?lamer | 2012 | Geotextiles and Geomembranes2012，，： | 1 |
| 17 | Identification of EMG signals using discriminant analysis and SVM classifier显示文摘 | Ahmet Alkan Mücahid Günay | 2011 | Expert Systems With Applications2011，，1： | 1 |
| 18 | The catalytic role of transition metal salts on supercritical water oxidation of phenol and chlorophenols in a titanium reactor显示文摘 | Ahmet M G Anthony A C Keith D B | 2003 | React Kinet Catal Lett2003，78，1： | 1 |
| 19 | Beneficial effects of chronic pharmacological manipulation of 13-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy 显示文摘 | Ahmet I Krawczyk M Heller P | 2004 | Circulation2004，110，9： | 1 |
| 20 | Inetervetional radiological treatment in complication of panereatitis显示文摘 | Ahmet M Mustafa P | 2002 | Eur Radio2002，439，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员