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| 1 | Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis显示文摘AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes.METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components.RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina Maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e Silva Robson Augusto Souza dos Santos | 2009 | World Journal of Gastroenterology2009，15，20： | 11 |
| 2 | Effect of propranolol on the splanchnic and peripheral renin angiotensin system in cirrhotic patients显示文摘AIM:To evaluate the effect of β-blockade on angiotensins in the splanchnic and peripheral circulation of cirrhotic patients and also to compare hemodynamic parameters during liver transplantation according to propranolol pre-treatment or not. METHODS:Patients were allocated into two groups:outpatients with advanced liver disease(LD) and during liver transplantation(LT). Both groups were subdivided according to treatment with propranolol or not. Plasma was collected through peripheral venipuncture to determine plasma renin activity(PRA),Angiotensin(Ang) Ⅰ,Ang Ⅱ,and Ang-(1-7) levels by radioimmunoassay in LD group. During liver transplantation,hemodynamic parameters were determined and blood samples were obtained from the portal vein to measure renin angiotensin system(RAS) components.RESULTS:PRA,Ang Ⅰ,Ang Ⅱ and Ang-(1-7) were signifi cantly lower in the portal vein and periphery in all subgroups treated with propranolol as compared to non-treated. The relationships between Ang-(1-7) and Ang Ⅰ levels and between Ang Ⅱ and Ang Ⅰ were significantly increased in LD group receiving propranolol. The ratio between Ang-(1-7) and Ang Ⅱ remained unchanged in splanchnic and peripheral circulation in patients under β-blockade,whereas the relationship between Ang Ⅱ and Ang Ⅰ was significantly increased in splanchnic circulation of LT patients treated with propranolol. During liver transplantation,cardiac output and index as well systemic vascular resistance and index were reduced in propranolol-treated subgroup. CONCLUSION:In LD group,propranolol treatment reduced RAS mediators,but did not change the ratio between Ang-(1-7) and Ang Ⅱ in splanchnic and peripheral circulation. Furthermore,the modification of hemodynamic parameters in propranolol treated patients was not associated with changes in the angiotensin ratio. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Renata da Cunha Ribeiro Renata Lúcia Pereira Vieira Jerusa Almeida Ana Paula Nadu Ana Cristina Sim■es e Silva Robson Augusto Souza Santos | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 3 | Elevated left and reduced right orbit-omedi: prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics 显示文摘 | Versace A Almeida JR Hassel S | 2008 | Arch Gen Psychiatry2008，65，： | 1 |
| 4 | Porcine circovirus 2 (PCV2) induces a procoagulant state in naturally infected swine and in cultured endothelial cells显示文摘 | Marks F S Reck J Jr Almeida L L | 2009 | Vet Microbiol2009，143，： | 1 |
| 5 | Human papillomavirus and oropharyngeal squamous cell carcinoma:what the clinician should know显示文摘 | Genden EM Sambur IM de Almeida JR | 2013 | Eur Arch Otorhinolaryngol2013，270，2： | 1 |
| 6 | Nonlymphoid mesenchymal tumors of the parotid gland显示文摘 | Takahama A Jr Le6n JE de Almeida OP | 2008 | Oral Oncol2008，，： | 1 |
| 7 | MR imaging for evaluation of lesions of the cranial vault: a pictorial essay 显示文摘 | Amaral L Chiurciu M Almeida JR | 2003 | Arq Neuropsiquiatr2003，61，3： | 1 |
| 8 | Right orbitofrontal corticolimbic and left corticocortical white matter connectivity differentiate bipolar and unipolar depression显示文摘 | Versace A Almeida JR Quevedo K | 2010 | Biol Psychiat2010，68，： | 1 |
| 9 | Characterization and kinetic compensation effect of corn biodiesel显示文摘 | DANTAS M B ALMEIDA A A F CONCEICAO M M FERNANDES V J Jr SANTOS I M G SILVA F C SOLEDADE L F B SOUZA A G | 2007 | J Therm Anal Calorim2007，87，3： | 1 |
| 10 | Tissue adhesives for a sutureless fadenoperation:an experimental study in a rabbit model显示文摘 | Tonelli E Jr de Almeida HC Bambirra EA | | 0，，12： | 1 |
| 11 | Robotic surgery for ompharynx cancer: promise, challenges, and future directions 显示文摘 | De Almeida JR Genden EM | 2012 | Curr Oncol Rep2012，14，1： | 1 |
| 12 | Correlation of androgen receptors, aromatase, and 5-alpha reductase in the human vagina with menopausal status显示文摘 | Berman JR Almeida FG Jolin J | 2003 | Fertil Steril2003，79，4： | 1 |
| 13 | Finite element stress analysis of edentulous mandibles with different bone types supporting multiple-implant super-structures显示文摘 | de Almeida EO Rocha EP Freitas AC JR | 2010 | Int J Oral Maxil- lofac Implants2010，25，6： | 1 |
| 14 | Contralateral nasolabial flap for a large nasal defect显示文摘 | Ponte P Goulao J de Almeida JR | 2009 | Dermatol Surg2009，35，： | 1 |
| 15 | Nanlymphoid mes- enchymal tumors of the parotid gland显示文摘 | Takahama A Jr Leon JE de Almeida OP | 2008 | Oral Oncol2008，44，10： | 1 |
| 16 | miR-155 modulates microgliamediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production 显示文摘 | Cardoso AL Guedes JR Pereira de Almeida L | 2012 | Immunology2012，135，1： | 1 |
| 17 | Autonomic Function in patients with functional dyspepsia assessed by 24-hour heart rate variability显示文摘 | Figueiredo MJ Almeida JR | 2002 | Dig Dis Sci2002，47，1： | 1 |
| 18 | An improved method for the determination of petroleum hydrocarbons from soil using a simple ultrasonic extraction and fourier transform infrared spectrophotometry显示文摘 | Couto MN Borges JR Guedes P Almeida R Monteiro E Almeida CMR Basto MCP Vaseoncelos MTSD | 2014 | Petroleum Science and Technology2014，32，4： | 1 |
| 19 | Clinical characteristics and in-hospital outcome of patients with acute coronary syndromes and systemic lupus erythematosus显示文摘 | de Matos Soeiro A de Almeida Soeiro MC de Oliveira MT Jr el al | 2014 | Rev Port Cardiol2014，33，11： | 1 |
| 20 | Phenylephrine for blood pressure control in electivecesarean section: therapeutic versus prophylactic doses显示文摘 | DAS NEVES J F MONTEIRO G A DE ALMEIDA Jr etal | 2010 | Rev Bras2010，60，4： | 1 |
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