|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | The feasibility of integrating ME-TVC+MEE with azzour south power plant:Economic evaluation显示文摘 | F N Alasfour A O Bin Amer | 2006 | Desalination2006，，197： | 1 |
| 3 | Quantitative gas-solid diazotization of 3-aminopyrazolo pyri- dine derivatives and azo dye synthesis by means of solid- solid reactions显示文摘 | Kaupp G Metwally M A Amer F A | 2003 | European Journal of Organic Chemis- try2003，8，： | 1 |
| 4 | Genotoxic effect of 2,4-dichlorophenoxy ace- tic acid and its metabolite 2,4-dichlorophenol in mouse显示文摘 | Amer S M Aly F A | 2001 | Mutat Res2001，494，12： | 1 |
| 5 | Therapeutic role of dietary lactobacilli and lactobacillic fermented dairy products显示文摘 | FERNANDES C F SHAHANI K M AMER M A | 1987 | FEMS Microbiology Letters1987，46，3： | 1 |
| 6 | Thermal analysis of METVC + MEE desalination systems 显示文摘 | ALAFOUR F N DARWISH M A BIN AMER A O | 2005 | Desalination2005，174，39： | 1 |
| 7 | Thermal analysis of ME - TVC + MEE desalination systems 显示文摘 | ALASFOUR F N DARISH M A BIN AMER A O | 2005 | Desalination2005，174，： | 1 |
| 8 | Characterization of soil phosphorus by anion exchange resin adsorption and P32 equilibraton 显示文摘 | AMER F BULDIN D R BLACK C A | 1955 | Plant Soil1955，6，： | 1 |
| 9 | Therapeutic role of dietary Lactobacilli and Lactoba- cillic fermented dairy productions 显示文摘 | FERNANDES C F SHAHANI K M AMER M A | 1987 | FEMS Microbi- ology Reviews1987，46，： | 1 |
| 10 | Industrial application of microbial lipases显示文摘 | HASAN F AMER A S HAMEED A | 2006 | Enz Microb Technol2006，39，2： | 1 |
| 11 | Characterization of soil phosphorus by anion exchange resin adsorption and 32p equilibraton显示文摘 | Amer F Buldin D R Black C A | 1955 | Plant Soil1955，6，： | 1 |
| 12 | Therapeutic role of dietary lactobacilli and lactobacillic fermented dairy products 显示文摘 | FERNANDES C F SHAHANI K M AMER M A | 1987 | FEMS Microbiol Rev1987，46，3： | 1 |
| 13 | Therapeutic role of dietary lactobacilli and lactobacillic fermented dairy products 显示文摘 | FERNANDES C F SHAHANI K M AMER M A | 1987 | FEMS Microbiol Rev1987，46，5： | 1 |
| 14 | Short communication:Effects of feeding sweet sorghum silage on milk production of lactating dairy cows显示文摘 | Amer S Seguin P Mustafa A F | 2012 | Journal of Dairy Science2012，95，2： | 1 |
| 15 | Relationship between circulating leptin and peripheral fat distribution in obese subjects显示文摘 | Wennlund A Amer P | 1997 | Int J Obes Relat Metab Disord1997，21，4： | 1 |
| 16 | Short communication:Effects of feeding sweet sorghum silage on milk production of lactating dairy cows显示文摘 | AMER S SEGUIN P MUSTAFA A F | 2012 | Journal of dairy science2012，95，： | 1 |
| 17 | Thermal analysis of ME-TVC+ MEE desali- nation systems 显示文摘 | ALASFOUR F N DARWISH M A BIN AMER A O | 2005 | Desalin2005，174，1： | 1 |
| 18 | Thermal analysis of ME-TVC+ MEE desalination systems显示文摘 | Alasfour F N Darwish M A Bin Amer A O | 2005 | Desalination2005，174，1： | 1 |
| 19 | Characterization of soil phosphorous by anion exchange resin and 32p equilibration 显示文摘 | AMER F BOULDEN D R BALCK C A | 1955 | Plant Soil1955，6，4： | 1 |
| 20 | Sonographic gallbladder wall thickness measurement and the prediction of esophageal varices among cirrhotics显示文摘Acute variceal bleeding in patients with liver cirrhosis and portal hypertension(PHT) is the most serious emergency complication among those patients and could have catastrophic outcomes if not timely managed. Early screening by esophago-gastro-duodenoscopy(EGD) for the presence of esophageal varices(EVs) is currently recommended by the practice guidelines for all cirrhotic patients. Meanwhile, EGD is not readily accepted or preferred by many patients. The literature is rich in studies to investigate and validate non-invasive markers of EVs prediction aiming at reducing the unneeded endoscopic procedures. Gallbladder(GB) wall thickness(GBWT) measurement has been found promising in many published research articles. We aim to highlight the validity of sonographic GBWT measurement in the prediction of EVs based on the available evidence. We searched databases including Cochrane library, Pub Med, Web of Science and many others for relevant articles. GBWT is associated with the presence of EVs in cirrhotic patients with PHT of different etiologies. The cut-off of GBWT that can predict the presence of EVs varied in the literature and ranges from 3.1 mm to 4.35 mm with variable sensitivities of 46%-90.9% and lower cutoffs in viral cirrhosis compared to non-viral, however GBWT > 4 mm in many studies is associated with acceptable sensitivity up to 90%. Furthermore, a relation was also noticed with the degree of varices and portal hypertensive gastropathy.Among cirrhotics, GBWT > 3.5 mm predicts the presence of advanced(grade Ⅲ-Ⅳ) EVs with a sensitivity of 45%, the sensitivity increased to 92% when a cut-off ≥ 3.95 mm was used in another cohort. Analysis of these results should carefully be revised in the context of ascites, hypoalbuminemia and other intrinsic GB diseases among cirrhotic patients. The sensitivity for prediction of EVs improved upon combining GBWT measurement with other non-invasive predictors, e.g., platelets/GBWT. | Mohamed H Emara Mariam Zaghloul Ibrahim F Amer Aya M Mahros Mohammed Hussien Ahmed Mahmoud A Elkerdawy Eslam Elshenawy Abdelrahman M Ahmed Rasheda Tarik I Zaher Mona Talaat Haseeb Emad Hassan Emara Hassan Elbatae | 2023 | World Journal of Hepatology2023，15，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员