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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 3 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 4 | Identification of mycobacteria and other acid fast organisms associated with pulmonary disease显示文摘 | AE Ani B Diarra UR Dahle C Lekuk F Yetunde AM Somboro Tounkara Anatole J Idoko | 2011 | Asian Pacific Journal of Tropical Disease2011，，4： | 2 |
| 5 | Laparoscopic mesh hiatoplasty for paraesophageal hernias and fundoplieations: a critical analysis of the available literature显示文摘 | Johnson JM Carbonell AM Carmody B J | 2006 | Surg Endose2006，20，3： | 1 |
| 6 | Urinary 8-hydroxy-2' -deoxyguanosine as a biological marker of in vivo oxidative DNA damage显示文摘 | Shigenaga M K Gimeno C J Ames B N | 1989 | Proc Natl Aead Sci USA1989，86，24： | 1 |
| 7 | The relevance of WHO injury surveillance guidelines for evaluation: learning from the aboriginal community-centered injury surveillance system (ACCISS) and two institution-based systems 显示文摘 | Auer AM Dobmeier TM Haglund B J et M | 2011 | BMC Public Heahh2011，11，： | 1 |
| 8 | The Recognition of Stroke in the Emergency Room(ROSIER)Scale:development and validation of a stroke recognition instrument显示文摘 | Nor AM Davis J Sen B | 2005 | Lancet Neurol2005，4，11： | 1 |
| 9 | Prevention of emergence agitation after sevoflurane anesthesia for pedi- atric cerebral magnetic resonance imaging by small dose of keta mine or nalbuphine ad ministerd just before dis- continuing anesthesia 显示文摘 | Dalens B J Pinard AM Lrtourneau DR | 2006 | Anesth Analg2006，102，4： | 1 |
| 10 | Casein peptide release and passage to the blood in humansduring digestion of milk and yogurt 显示文摘 | Chabance B Marteau P Rambaud J C et aL AM | 1998 | Biochimie1998，80，2： | 1 |
| 11 | A Marker of Oxyradieal-mediated DNA Damage (8-hydroxy-2-deoxyguanosine) Is Increased in Nigro-striatum of Parkinson's Disease Brain显示文摘 | SANCHEZ-RAMOS J OVERVIK E AMES B | 1994 | Neurodegeneration( S1055 - 8330)1994，3，： | 1 |
| 12 | Lactulose in the treatment of symptomatic diverticular disease: A comparative study with high-fibre diet 显示文摘 | Smits B J Whitehead AM Prescott P | 1990 | Br J Clin Pract1990，44，： | 1 |
| 13 | Studies on thermostable antigens, production of species-specific antiadrenal sera and comparison of immunological techniques in meat speciation显示文摘 | Sherikar A T Karkare U D Khot J B et am | 1993 | Meat Sci1993，33，1： | 1 |
| 14 | The cytochromeP450 4A/F-20 -hydroxyeicosatetraenoic acid system : aregulator of endothelial precursor cells derived fromhuman umbilical cord blood 显示文摘 | Guo AM Janie B Sheng J | 2011 | J Pharmacol ExpTher2011，338，2： | 1 |
| 15 | Interactions between NF-κB and SP3 connect inflammatory signaling with reduced FGF-10 expression显示文摘 | Carver B J Plosa EJ Stinnett AM | 2013 | J Biol Chem2013，288，15： | 1 |
| 16 | Genotypic vatiations in the accumulation of Cd, Cu, Pb and Zn exhibited by six commonly grown vegetables显示文摘 | Alexander PD Alloway B J Dourado AM | 2006 | Environ- mental Pollution2006，144，： | 1 |
| 17 | Tumor necrosis factor alpha (TNF- ct ) inactivates the PI3-kinase/PKB pathway and induces atrophy and apoptosis in L6 myotubes 显示文摘 | Sishi B J Engelbrecht AM | 2011 | Cytokine2011，54，2： | 1 |
| 18 | Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens 显示文摘 | Thiantanawat A Long B J Brodie AM | 2003 | Cancer Res2003，63，： | 1 |
| 19 | C - erbB growth facter recepotor proteins in ovarian tumours 显示文摘 | Simpon B J Phillips HA Lessells AM | 1995 | Int J Cancer1995，64，3： | 1 |
| 20 | An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function 显示文摘 | McCann J C Ames B N | 2007 | Am J Clin Nutr2007，85，4： | 1 |
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