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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | Plasmonics for solid-state lighting: enhanced excitation and directional emission of highly efficient light sources显示文摘Light sources based on reliable and energy-efficient light-emitting diodes (LEDs) are instrumental in the development of solid-statelighting (SSL). Most research efforts in SSL have focused on improving both the intrinsic quantum efficiency (QE) and the stability oflight emitters. For this reason, it is broadly accepted that with the advent of highly efficient (QE close to 1) and stable emitters, thefundamental research phase of SSL is coming to an end. In this study, we demonstrate a very large improvement in SSL emission (above70-fold directional enhancement for p-polarized emission and 60-fold enhancement for unpolarized emission) using nanophotonicstructures. This is attained by coupling emitters with very high QE to collective plasmonic resonances in periodic arrays of aluminumnanoantennas. Our results open a new path for fundamental and applied research in SSL in which plasmonic nanostructures are able tomold the spectral and angular distribution of the emission with unprecedented precision. | Gabriel Lozano Davy J Louwers Said RK Rodrı´guez Shunsuke Murai Olaf TA Jansen Marc A Verschuuren Jaime Gomez Rivas | 2013 | Light(Science & Applications)2013，2，1： | 8 |
| 3 | Serrated adenoma of the stomach:Case report and literature review显示文摘Gastric serrated adenomas are histologically characterized by protruding glands with lateral saw tooth-like indentations lined with stratified dysplastic cells containing abundant eosinophilic cytoplasm.Since the first case of gastric serrated adenoma found in 2001,18 additional cases have been reported.Gastric serrated adenomas have a particular proclivity to progress to invasive carcinoma;75% or 15 of the 20 cases now in record-including the present one-exhibited invasive carcinoma.The 20 th case of gastric serrated adenoma reported here differs from the preceding ones in as much as it evolved in a patient with Lynch syndrome,implying that this adenoma phenotype may develop not only sporadically but also in patients with hereditary traits. | Carlos A Rubio Jan Bjrk | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 4 |
| 4 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 5 | Orphanin FQ:a neuropeptide that activates an opioidlike G protein-coupled receptor显示文摘 | Reinscheid RK Nothacker HP Bourson A | | 0，，： | 2 |
| 6 | Characterisation of the novel apoptotie and therapeutic activities of the histone deacetylase inhibitor romid epsin 显示文摘 | Newbold A Lindemann RK Cluse LA | 2008 | Mol Cancer Ther2008，7，5： | 1 |
| 7 | Nasal mucociliary clearance in adenotomillar hypertrophy显示文摘 | Singh J Cera A | 2000 | Indian J Pediar2000，67，7： | 1 |
| 8 | Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss显示文摘 | Shepherd RK Coco A Epp SB | 2008 | Hear Res2008，242，： | 1 |
| 9 | Coring of laminated lake sediments for pigment and mineral magnetic analyses, Sondre Stromfjord, southern West Greenland 显示文摘 | Anderson N J Clarke A Juhler RK | 2000 | Geology of Greenland Survey Bulletin2000，186，： | 1 |
| 10 | Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor显示文摘 | JAIN RK SAFABAKHSH N SCKELL A | 1998 | Proc Natl Acad Sci USA1998，95，10： | 1 |
| 11 | Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele 显示文摘 | Saleh RA Agarwal A Sharma RK | 2003 | FertilSteril2003，80，6： | 1 |
| 12 | Gial calcium:homeostasis and signaling function 显示文摘 | Verkhratsky A Orkand RK Kettenmann H | 1998 | Physiol Rev1998，78，1： | 1 |
| 13 | Prospective evaluation of in vivo proton MR spectroscopy in differentiation of similar appearing intracranial cystic lesions显示文摘 | Davea A Guptaa RK Royd R | 2001 | J Magn Reson Imag2001，19，： | 1 |
| 14 | Primerdirected enzymatic amplification of DNA with a thermostable DNA polymerase显示文摘 | SAIKI RK GELFAND DH STOTTELS A | 1988 | Science1988，239，： | 1 |
| 15 | Massive primary chylopericardium in an infant显示文摘 | Anil SR Manoj P Hejmadi A Kumar RK | 2002 | Indian Heart J2002，54，3： | 1 |
| 16 | Role of foetomaternal haemorrhage in the causation of anaemia in the newborn infant显示文摘 | Saini RK Walia BN Prakash A | 1973 | Indian Pediatr1973，10，12： | 1 |
| 17 | Quantitative evaluation of inflammatory and immune responses in the early stages of chronic Helicobacter trylori infection 显示文摘 | Straubinger RK Greiter A McDonough SP | 2003 | Infect Immune2003，71，5： | 1 |
| 18 | Effect of time of nitrogen application on spikelet differentiation and degeneration of rice显示文摘 | Saha A Sarkar RK Yamagishi Y | 1998 | Bot BullAcadSin1998，39，： | 1 |
| 19 | Impact of nutritional status on peritonitis in CAPD patients 显示文摘 | Prasad N Gupta A Sharma RK | 2007 | Perit Dial Int2007，27，1： | 1 |
| 20 | MAP kinase genes and colon and rectal cancer显示文摘 | Slattery ML Lundgreen A Wolff RK | 2012 | Carcinogenesis2012，33，12： | 1 |
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