|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical correlates of common corneal neovascular diseases: a literature review显示文摘A large subset of corneal pathologies involves the formation of new vessels(neovascularization), leading to compromised visual acuity. This article aims to review the clinical causes and presentations of corneal neovascularization(CNV) by examining the mechanisms behind common CNV-related corneal pathologies, with a particular focus on herpes simplex stromal keratitis,contact lenses-induced keratitis and CNV secondary to keratoplasty. Moreover, we reviewed CNV in the context of different types of corneal transplantation and keratoprosthesis, and summarized the most relevant treatment available so far. | Nizar Saleh Abdelfattah Mohamed Amgad Amira A Zayed Hamdy Salem Ahmed E Elkhanany Heba Hussein Nawal Abd El-Baky | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 10 |
| 2 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 3 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 4 | Host immune cellular reactions in corneal neovascularization显示文摘Corneal neovascularization(CNV) is a global important cause of visual impairment. The immune mechanisms leading to corneal heme- and lymphangiogenesis have been extensively studied over the past years as more attempts were made to develop better prophylactic and therapeutic measures. This article aims to discuss immune cells of particular relevance to CNV, with a focus on macrophages, Th17 cells, dendritic cells and the underlying immunology of common pathologies involving neovascularization of the cornea. Hopefully, a thorough understanding of these topics would propel the efforts to halt the detrimental effects of CNV. | Nizar S.Abdelfattah Mohamed Amgad Amira A Zayed | 2016 | International Journal of Ophthalmology(English edition)2016，9，4： | 5 |
| 5 | Vascular depression for radiology: A review of the construct,methodology,and diagnosis显示文摘Vascular depression(VD)as defined by magnetic resonance imaging(MRI)has been proposed as a unique subtype of late-life depression.The VD hypothesis posits that cerebrovascular disease,as characterized by the presence of MRIdefined white matter hyperintensities,contributes to and increases the risk for depression in older adults.VD is also accompanied by cognitive impairment and poor antidepressant treatment response.The VD diagnosis relies on MRI findings and yet this clinical entity is largely unfamiliar to neuroradiologists and is rarely,if ever,discussed in radiology journals.The primary purpose of this review is to introduce the MRI-defined VD construct to the neuroradiology community.Case reports are highlighted in order to illustrate the profile of VD in terms of radiological,clinical,and neuropsychological findings.A secondary purpose is to elucidate and elaborate on the measurement of cerebrovascular disease through visual rating scales and semi-and fully-automated volumetric methods.These methods are crucial for determining whether lesion burden or lesion severity is the dominant pathological contributor to VD.Additionally,these rating methods have implications for the growing field of computer assisted diagnosis.Since VD has been found to have a profile that is distinct from other types of late-life depression,neuroradiologists,in conjunction with psychiatrists and psychologists,should consider VD in diagnosis and treatment planning. | Sara N Rushia Al Amira Safa Shehab Jeffrey N Motter Dakota A Egglefield Sophie Schiff Joel R Sneed Ernst Garcon | 2020 | World Journal of Radiology2020，12，5： | 5 |
| 6 | Formation of enzymes by biodegradation of agricultural wastes with white rot fungi显示文摘 | Nadia H Abd E1 - Nasser Samia MHelmy Amira A E1 - Gammal | 1997 | Polymer Degradation and Stability1997，55，： | 2 |
| 7 | Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice显示文摘Objective In this study, the ameliorative effects of gold nanoparticles(gold NP) on the renal tissue damage in Schistosoma mansoni(S. mansoni)-infected mice was investigated. Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice. Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-β mR NA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection. Conclusion The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers. | Mohamed A Dkhil Mona F Khalil2 Amira A Bauom Marwa SM Dia Saleh A1-Qura | 2016 | Biomedical and Environmental Sciences2016，29，11： | 2 |
| 8 | Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model显示文摘AIM: To develop a mathematical model for the early detection of hepatocellular carcinoma(HCC) with a panel of serum proteins in combination with α-fetoprotein(AFP).METHODS: Serum levels of interleukin(IL)-8, soluble intercellular adhesion molecule-1(s ICAM-1), soluble tumor necrosis factor receptor Ⅱ(s TNF-RⅡ), proteasome, and β-catenin were measured in 479 subjects categorized into four groups:(1) HCC concurrent with hepatitis C virus(HCV) infection(n = 192);(2) HCV related liver cirrhosis(LC)(n = 96);(3) Chronic hepatitis C(CHC)(n = 96); and(4) Healthy controls(n = 95). The R package and different modules for binary and multi-class classifiers based on generalized linear models were used to model the data. Predictive power was used to evaluate the performance of the model. Receiver operating characteristic curve analysis over pairs of groups was used to identify the best cutoffs differentiating the different groups. RESULTS: We revealed mathematical models, based on a binary classifier, made up of a unique panel of serum proteins that improved the individual performance of AFP in discriminating HCC patients from patients with chronic liver disease either with or without cirrhosis. We discriminated the HCC group from the cirrhotic liver group using a mathematical model(-11.3 + 7.38 × Prot + 0.00108 × s ICAM + 0.2574 ×β-catenin + 0.01597 × AFP) with a cutoff of 0.6552, which achieved 98.8% specificity and 89.1% sensitivity. For the discrimination of the HCC group from the CHC group, we used a mathematical model [-10.40 + 1.416 × proteasome + 0.002024 × IL + 0.004096 × s ICAM-1 +(4.251 × 10-4) × s TNF + 0.02567 ×β-catenin + 0.02442 × AFP] with a cutoff 0.744 and achieved 96.8% specificity and 89.7% sensitivity. Additionally, we derived an algorithm, based on a binary classifier, for resolving the multi-class classification problem by using three successive mathematical model predictions of liver disease status. CONCLUSION: Our proposed mathematical model may be a useful method for the early detection of different statuses of liver disease co-occurring with HCV infection. | Abdel-Rahman Nabawy Zekri Amira Salah El-Din Youssef Yasser Mabrouk Bakr Reham Mohamed Gabr Ola Sayed Ahmed Mostafa Hamed Elberry Ahmed Mahmoud Mayla Mohamed Abouelhoda Abeer A Bahnassy | 2016 | World Journal of Gastroenterology2016，22，16： | 2 |
| 9 | Evaluation of an educational training programme for the development of trainers in child mental health in Alexandria显示文摘 | Amira G S E D Faten A K Randa M | 1996 | East Med Health1996，2，3： | 1 |
| 10 | FPGA implementations of fast Fourier transforms for real-time signal and image processing显示文摘 | Uzun I S Amira A Bouridane A | | 0，，03： | 1 |
| 11 | FPGA reali-zation of FIR filters by efficient and flexible systoliza-tion using distributed arithmetic 显示文摘 | Meher P K Chandrasekaran S Amira A | | 0，，07： | 1 |
| 12 | Soluble methionine enhances accumulation of a 15 kDa zein, a methionine- rich storage protein, in transgenic alfalfa but not in transgenic tobacco plants 显示文摘 | Amira G Ifat M Tal A Hana B Shmuel Rachel A | 2005 | Journal of Experimental Botany2005，56，419： | 1 |
| 13 | cytotoxic and antioxidant activity Sulforaphane composition, of crucifer vegetables显示文摘 | MOHAMED A F AMIRA A M | 2010 | Journal of Advanced Research2010，1，： | 1 |
| 14 | FPGA Implementations of Fast Fourier Transforms for Real-Time Signal and Image Processing显示文摘 | Uzun I S Amira A Bouridane A | 2005 | IEE Proeedings Vision Image & Signal processing2005，152，3： | 1 |
| 15 | Tumor anti-initiating activity of some novel 3, 4-dihydropyrimidinones显示文摘 | Hanaa A T Fatma B Amira M G | 2009 | Pharmacological Reports2009，61，： | 1 |
| 16 | Three ports laparo- scopic resection for colorectal cancer:, a step on refining of reduced port surgery显示文摘 | Tawfik Amin A Elsaba TM Amira G | 2014 | ISRN Surg2014，2014，78： | 1 |
| 17 | An eco - friendly - nov approach for attaining wrinkle - free/soft - hand cotton fabric 显示文摘 | MOHAMED H NABIL A I AMIRA E | 2009 | Car bohydrate Polymers2009，78，： | 1 |
| 18 | Application of reactive cyclodextrin poly butyl acrylate preformed polymers containing nano-ZnO to cot- ton fabrics and their impact on fabric performance显示文摘 | AMIRA E S SHAARAWY S HEBEISH A | 2010 | Carbohydr Polym2010，79，： | 1 |
| 19 | Oxidative stress and disease: an updated re- view 显示文摘 | Amira A MAdly | 2010 | Research Journal of Immunology2010，3，2： | 1 |
| 20 | FPGA realization of FIR filters by efficient and flexible systolization using distributed arithmetic显示文摘 | Meher P K Chandrasekaran S Amira A | 2008 | Signal Processing IEEE Transactions on2008，56，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员