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| 1 | Unexpected alliance between syndecan-1 and innatelike T cells to protect host from autoimmune effects of interleukin-17显示文摘Innate-like T cells, namely natural killer T(NKT) and γδ T cells, play critical roles in linking innate and adaptive immune responses through rapid production of cytokines. Prominent among these cytokines is interleukin-17(IL-17), which is a potent proinflammatory cytokine that plays a critical role in host defense against fungi and extracellular bacteria. However, excessive IL-17-production promotes autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. IL-17 has also been implicated in regulating body fat, which is highly relevant given rises in obesity and type 2 diabetes. NKT cells, γδ T cells and mucosal-associated invariant T cells(MAIT) are the major sources of IL-17 involved in protection of mucosal surfaces from opportunistic infections and causing autoimmunity when become dysregulated. Given the pathogenic effects of IL-17, efforts have been directed towards understanding mechanisms that guard against IL-17 overproduction. One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1(sdc1), which is selectively expressed by IL-17-producing subsets of NKT and γδ T cells. This unexpected role for sdc1 is uncovered by analysis of NKT and γδ T cells in sdc1-deficient mice. In this mini-review, we discuss selective expression of sdc1 by these innate T cells and consequences of its absence on IL-17 homeostasis and pathological implications. | Anil Kumar Jaiswal Mohanraj Sadasivam Abdel Rahim A Hamad | 2018 | World Journal of Diabetes2018，9，12： | 5 |
| 2 | Total hip arthroplasty in fused hips with spine stiffness in ankylosing spondylitis显示文摘Ankylosing spondylitis(AS)is characterized by involvement of the spine and hip joints with progressive stiffness and loss of function.Functional impairment is significant,with spine and hip involvement,and is predominantly seen in the younger age group.Total hip arthroplasty(THA)for fused hips with stiff spines in AS results in considerable improvement of mobility and function.Spine stiffness associated with AS needs evaluation before THA.Preoperative assessment with lateral spine radiographs shows loss of lumbar lordosis.Spinopelvic mobility is reduced with change in sacral slope from sitting to standing less than 10 degrees conforming to the stiff pattern.Care should be taken to reduce acetabular component anteversion at THA in these fused hips,as the posterior pelvic tilt would increase the risk of posterior impingement and anterior dislocation.Fused hips require femoral neck osteotomy,true acetabular floor identification and restoration of the hip center with horizontal and vertical offset to achieve a good functional outcome.Cementless and cemented fixation have shown comparable long-term results with the choice dependent on bone stock at THA.Risks at THA in AS include intraoperative fractures,dislocation,heterotopic ossification,among others.There is significant improvement of functional scores and quality of life following THA in these deserving young individuals with fused hips and spine stiffness. | Anil Thomas Oommen Triplicane Dwarakanathan Hariharan Viruthipadavil John Chandy Pradeep MathewPoonnoose Arun Shankar A Roncy Savio Kuruvilla Jozy Timothy | 2021 | World Journal of Orthopedics2021，12，12： | 2 |
| 3 | The role of transsphenoidal surgery in the treatment of craniopharyngiomns显示文摘 | Maim G Anile C Albanese A | 2004 | J Neurosurg2004，100，3： | 1 |
| 4 | Cerebrospinal fluid shunting for hy- drocephalus in the adult:factors related to shunt revision显示文摘 | Puca A Anile C Maira G | 1991 | Neurosurgery1991，29，6： | 1 |
| 5 | Massive primary chylopericardium in an infant显示文摘 | Anil SR Manoj P Hejmadi A Kumar RK | 2002 | Indian Heart J2002，54，3： | 1 |
| 6 | Troglitazone prevents and dexamethasone induced insulin resistance on glycogen synthesis in 3T3 adipocyte 显示文摘 | Anil Kumar K L Marita A R | 2000 | Br J Pharmacol2000，130，： | 1 |
| 7 | Pure surgical treatments of109 aneurysms显示文摘 | Maira G Anile C Mangiola A et a1 | 2005 | J Neurosurg Sci2005，49，2： | 1 |
| 8 | Modeling Reaction Quench Times in the Waste Heat Boiler of a Claus Plant 显示文摘 | Nasato Linda V Karan Kunal Mehrotra Anil K Behie Leo A | 1994 | Ind Eng Chem Res1994，33，： | 1 |
| 9 | Matching of Palmprlnts显示文摘 | Nicolae Duta Anil K J a in Kanti V Mardia | 2002 | Pattern Recognition Letters2002，23，： | 1 |
| 10 | Paclitaxel and its formulations显示文摘 | Anil KS Alka G Deepika A | 2002 | Inter J Pharmac2002，235，1： | 1 |
| 11 | Unsupervised Learning of Finite Mixture Models 显示文摘 | Mario A T Figueiredo Anil K Jain | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，3： | 1 |
| 12 | Cerebrospinal fluid shunting for hydrocephalus in adult factors related to shunt revision显示文摘 | Puca A Anile C Maira G | 1991 | Neurosurgery1991，29，6： | 1 |
| 13 | Resetting semiactives tiffness damper for seismic response control 显示文摘 | Jann N Y Kim J H Anil K A | 2000 | ASCE Journal of Structural Engineering2000，126，14： | 1 |
| 14 | Cerebrospinal fluid shunting for hydro-cephalus in adult:factors related to shunt rivision显示文摘 | PUCA A ANILE C MAIRA C | 1991 | Neurosurgery1991，29，3： | 1 |
| 15 | Sleeve lobectomy compared with pneumonectomy aider induction therapy for non-small-cell lung cancer显示文摘 | Maurizi G D'Andrilli A Anile M | 2013 | J Thorac Oncol2013，8，5： | 1 |
| 16 | Glioblastoma therapy: going beyond Hercules Colurrms显示文摘 | Mangiola A Anile C Pompueci A | 2010 | Expert Rev Neurother2010，10，4： | 1 |
| 17 | Unsupervised learning of finite mixture models显示文摘 | Mario A T Figueiredo Anil K Jean | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，3： | 1 |
| 18 | Computer Immunology显示文摘 | Steven A Hofmeyr Anil Somayaji | 1997 | Communication of the ACM1997，40，10： | 1 |
| 19 | Recent advances in microencapsulation of probiotics for industrial applications and targeted delivery 显示文摘 | ANIL K A HARJINDER S | 2007 | Trend Food Sei Teeh2007，18，5： | 1 |
| 20 | Cerebrospinal fluid shunting for hydrocephalus in adult: factors related to shunt rivision 显示文摘 | Puca A Anile C Maira G | 1991 | Neurosurgery1991，29，6： | 1 |
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