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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Role of GGF/Neuregulin Signaling in Interactions between Migrating Neurons and Radial Glia in the Developing Cerebral Cortex显示文摘 | Anton E S Marehionni M A Lee K F | 1997 | Development1997，124，18： | 1 |
| 3 | Use of the 16S-23S ribosomal genes spacer region in studies of prokaryotic diversity显示文摘 | Garcia-Martinez J Acinas S G Anton AI Rodriguez-Valera F | 1999 | Microbial Meth1999，36，： | 1 |
| 4 | Preparation and surface properties of acrylic polymers containing fluorinated monomers 显示文摘 | Richard R Thomas D R Anton W F | 1997 | Macromolecules1997，30，： | 1 |
| 5 | Two-dimensional video disdrometer: a description显示文摘 | WITOLD F Krajewski Anton Kruger | 2002 | Journal of Atmospheric and Oceanic Technology2002，，19： | 1 |
| 6 | Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro 显示文摘 | Steen KH Reeh PW Anton F | 1992 | J Neurosci1992，12，： | 1 |
| 7 | Nerve growth factor and its low affinity receptor promote Schwann cell Mgration显示文摘 | ANTON E S WESKAMP G REICHARDT L F | 1994 | Proc Nail Acad Sci USA1994，91，7： | 1 |
| 8 | Cryosurgical ablation of liver tumors in colon cancer patients increases the serum total ganglioside level and then selectively augments antiganglioside IgM显示文摘 | Mepur H Ravindranath Thomas F Wood Daniel Soh Alexandra Gonzales Sakunthala Muthugounder Carlos Perez Donald L Morton Anton J Bilchik | 2002 | Cryobiology2002，，1： | 1 |
| 9 | Morphine,5-HT2 and 5-HT3 receptor antagonists reduce c-fos expression in the trigeminal nucear complex following noxious chemical stimulation of the rat nasal mucosa显示文摘 | Ebersberger A Anton F Tolle TR | 1995 | Brain Res1995，676，2： | 1 |
| 10 | Cloning and characterization of the Bg/Ⅱ restriction-modification system reveals a possible evolutionary footprint显示文摘 | ANTON B P HEITER D F BENNER J S | 1997 | Gene1997，187，1： | 1 |
| 11 | Transformation of Lily by agrobacterium显示文摘 | Langeveld S A Gerrits M M Anton F L M | 1995 | Euphytica1995，85，： | 1 |
| 12 | Preparation and surface properties of acrylic polymers containing fluorinated monomers 显示文摘 | Thomas R R Anton D R Graham W F | 1997 | Macromolecules1997，30，： | 1 |
| 13 | Films containing reactive mixtures of perfluoroalkylethyl methacrylate copolymers and fluorinated isocyanates: synthesis and surface properties 显示文摘 | Thomas R R Anton D R Graham W F | 1998 | Macromolecules1998，31，： | 1 |
| 14 | Magnetofec-tion : enhancing and targeting gene delivery by magnetic force invitro and in vivo 显示文摘 | SCHERER F ANTON M SCHILLINGER U | 2002 | Gene Therapy2002，9，2： | 1 |
| 15 | Films containing reactive mixtures of perfluoroalkylethyl methacrylate copolymers and fluorinated isocyanates: Synthesis and surface properties 显示文摘 | Thomas R Anton D R Graham W F | 1998 | Macromolecules1998，31，14： | 1 |
| 16 | Peptides as functional surfactants显示文摘 | Dexter A F Anton P J Middelberg G | 2008 | Industrial and Engineering Chemistry Research2008，47，17： | 1 |
| 17 | Preparation and surface properties of acrylic polymers containing fluorinated monomers 显示文摘 | Thomas R R Anton D R Graham W F | 1997 | Macromolecules1997，30，10： | 1 |
| 18 | Randomized phase Ⅲstudy of gemcitabine-cisplatin versus etoposide-cisplatin in the treatment of locally advanced or metastatic non-small-cell lung cancer显示文摘 | Cardenal F Lopez-Cabrerizo MP Anton A | 1999 | J Clin Oncol1999，17，1： | 1 |
| 19 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 20 | Randomized phase Ⅲ study of gemcitabine-cisplatin versus etoposide-cisplatin in the treatment of locally advanced or metastotic non-small-cell lung cancer 显示文摘 | Cardenal F Lopez-Cabrerizo NIP Anton A | 1999 | J Clin Oncol1999，17，1： | 1 |
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