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| 1 | Adenoid cystic carcinoma of breast: Recent advances显示文摘Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. | Kosuke Miyai Mary R Schwartz Mukul K Divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro | 2014 | World Journal of Clinical Cases2014，2，12： | 16 |
| 2 | Antioxidant efficiency of lycopene on oxidative stress-induced damage in bovine spermatozoa显示文摘Background: Lycopene(LYC) is a natural carotenoid with powerful reactive oxygen species(ROS) scavenging activities. The aim of this study was to investigate if lycopene has the ability to reverse ROS-mediated alterations to the motility, viability and intracellular antioxidant profile of bovine spermatozoa subjected to ferrous ascorbate(Fe AA). Spermatozoa were washed out of fresh bovine semen, suspended in 2.9 % sodium citrate and subjected to LYC treatment(0.25, 0.5, 1 or 2 mmol/L) in the presence or absence of Fe AA(150 μmol/L Fe SO_4 and 750 μmol/L ascorbic acid) during a 6 h in vitro culture. Spermatozoa motion characteristics were assessed using the Sperm Vision?computer-aided sperm analysis(CASA) system. Cell viability was examined with the metabolic activity(MTT) assay,ROS generation was quantified via luminometry and the nitroblue-tetrazolium(NBT) test was applied to quantify the intracellular superoxide formation. Cell lysates were prepared at the end of the in vitro culture to investigate the intracellular activity of superoxide dismutase(SOD), catalase(CAT), glutathione peroxidase(GPx) as well as the concentrations of glutathione(GSH) and malondialdehyde(MDA).Results: FeA A treatment led to a reduced spermatozoa motility(P < 0.001), viability(P < 0.001) and a decline of the antioxidant capacity of spermatozoa(P < 0.001) but increased the ROS generation(P < 0.001), superoxide production(P < 0.001) and lipid peroxidation(P < 0.001). LYC administration resulted in a preservation of the spermatozoa motion parameters(P < 0.001), mitochondrial activity(P < 0.001) and antioxidant characteristics(P < 0.001 with respect to SOD;P < 0.01 in relation to CAT; P < 0.05 as for GPx and GSH) with a concentration range of 1 and 2 mmol/L LYC revealed to be the most effective.Conclusions: Our results suggest that LYC exhibits significant ROS-scavenging and antioxidant properties which may prevent spermatozoa alterations caused by oxidative stress, and preserve the functionality of male reproductive cells. | Eva Tvrdá Anton Kovácik Eva Tusimová Dusan Paál Alica Mackovich Jakhongir Alimov Norbert Lukác | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 3 |
| 3 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 4 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 5 | The heterogeneous advantage:biodiesel by catalytic reactive distillation显示文摘 | KISS ANTON A FLORIN OMOTA DIMIAN ALEXANDRE C | 2006 | Topics in Catalysis2006，40，： | 1 |
| 6 | Biodiesel by catalytic reactive distillation powered by metal oxides显示文摘 | KISS ANTON A DIMIAN ALEXANDRE C GADI ROTHENBERG | 2008 | Energy & Fuels2008，22，： | 1 |
| 7 | Formylation of allylsilanes:a synthesis of β,y-unsaturated aldehyde acetals显示文摘 | Englbert B Herbert M | 1989 | Synthesis1989，，2： | 1 |
| 8 | Inquiry-based Requirements Analysis显示文摘 | Potts C Takahashi K Anton A I | 1994 | IEEE1994，，3： | 1 |
| 9 | Pharmacogenomics in lung cancer:an analysis of DNA repair gene expression in patients treated with platinum-based chemotherapy显示文摘 | Garcia C R Alonso C G Anton A | 2005 | Expert Opin Pharmacother2005，6，12： | 1 |
| 10 | A comparison of CA125, HE4, risk ovarian malignancy algorithm (RO- MA) ,and risk malignancy index(RMI) for the classifica- tion of ovarian masses显示文摘 | Anton C Carvalho FM Oliveira EI | 2012 | Clinics2012，67，5： | 1 |
| 11 | Dissolution of Amorphous Aluminosilicate Zeolite Precursors in Alkaline Solutions (Part 2): Mechanism of the Dissolution显示文摘 | Antonic T Cizmek A Kosanovic C | 1994 | Journal of the Chemical Society Faraday Transactions1994，90，13： | 1 |
| 12 | Magnetic liquid sensor for very' low gas flow I'ate with magnetic flow adjusting possibility显示文摘 | Popa N C Potencz I Anton I | 1997 | Sensors and Actuators A1997，59，13： | 1 |
| 13 | A comparison of CA125, HE4, risk ovarian malignaney algorithm (ROMA), and risk malignancy index (RMI) for the classification of ovarian masses 显示文摘 | Anton C Carvalho FM Oliveira EI | 2012 | Clinics(Sao Paulo)2012，67，5： | 1 |
| 14 | The transmissible gastroenteritis coronavirus contains a spherical core shell consisting of M and N proteins显示文摘 | Risco C Anton I M Enjuanes L | 1996 | J Virol1996，70，7： | 1 |
| 15 | History of the pan-creas显示文摘 | Antonic C Busnardo M D Liberato J A | 1983 | Am J Surg1983，146，5： | 1 |
| 16 | Correlates ofspontane- ous reporting of adverse drug reactions within primary care: the paradox of low prescribers who are hishreporters 显示文摘 | Cox AR Anton C McDowell SE | 2010 | Br J Clin Pharmaco12010，69，5： | 1 |
| 17 | Clinical relevance of the cagA , vacA , and iceA status of Helicobacter pylori显示文摘 | Leen–Jan van Doorn * Céu Figueiredo * ? Ricardo Sanna * Anton Plaisier § Peter Schneeberger ∥ Wink de Boer ? Wim Quint * | 1998 | Gastroenterology1998，，1： | 1 |
| 18 | Nanoparticles by spray drying using innovative new technology: the Biachi nano spray dryer B-90 显示文摘 | Li X Anton N Arpagaus C | 2010 | J Controlled Release2010，147，2： | 1 |
| 19 | A cross-layer approach to transmit antenna selection显示文摘 | VICARIO J L LAGUNAS M A ANTON H C | 2006 | IEEE Transactions on Wireless Communications2006，5，8： | 1 |
| 20 | The bactericidal/permeability-increasing protein (BPI) is present in specific granules of human e osinophils显示文摘 | Jero C Hans J Anton T | 1998 | Blood1998，91，： | 1 |
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