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| 1 | Inclusion Modification with Mg Treatment for 35CrNi3MoV Steel显示文摘The effects of Mg on the inclusion characteristics of 35CrNi3MoV steel have been studied. The results show that Mg treatment reduces obviously the amount of inclusion in the steel.Magnesiurn and oxygen in liquid steel form dispersed fine particles of MgO, to which other oxides or sulphides nucleated at heterogeneity and grown during solidification. In this way the inclusions are modified. The small spherical inclusions containing MgO have been observed in the Mg treated steel in contrast to the large angular inclusions with Al2O3 in the conventional steel. Especially the elongated MnS inclusion is replaced by small MgS·MgO or MgS. MnS·MgO complex inclusion. The formation of inclusions have been discussed. | Fu, J Yu, YG Wang, AR Chen, BP Sun, WS | 1998 | Journal of Materials Science & Technology1998，14，1： | 22 |
| 2 | 小胶质细胞再激活可缓解脑损伤后炎症反应并促进脑功能恢复显示文摘中枢神经系统疾病或损伤后,小胶质细胞介导的慢性神经炎症反应会损伤局部脑组织,加重病情,不利于神经功能的恢复。小胶质细胞的激活通过集落刺激因子1受体(CSF1R)信号通路,CSF1R抑制剂可阻断小胶质细胞的激活。抑制慢性神经炎症反应是治疗中枢神经系统疾病的有效方法,但长时间抑制小胶质细胞在临床实践中无法实现。值得注意的是,去掉CSF1R抑制剂可刺激中枢神经系统内新的小胶质细胞的彻底重激活。本课题组建立小鼠广泛性神经元丢失模型,在该模型中探讨急性小胶质细胞的消除及再激活的作用。神经元的丢失导致了较长时间的神经炎性反应,表现为小胶质细胞肿胀,并表达CD68和CD45;同时,细胞因子、趋化因子、补体及其他炎症信号的表达增加。小胶质细胞的再激活可以缓解上述炎症反应,还可以促进小鼠神经功能的恢复,即使该小鼠的海马神经元丢失80%,其在水迷宫测试中的得分与正常小鼠的得分相差无几。对突触的分析结果显示,小胶质细胞的再激活可增加PSD95和突触泡蛋白点状突触体的表达,提示小胶质细胞有助于重塑和调节突触的形态和功能。综上所述,本研究结果显示,小胶质细胞的短时间消除及再激活可能是一种新颖有效的方法用于减少神经炎性反应并促进脑功能恢复。 | Rice RA Pham J Lee RJ Najafi AR West BL Green KN 唐颖馨(编译) | 2017 | 神经损伤与功能重建2017，12，3： | 9 |
| 3 | Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity显示文摘AIM:To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.METHODS:The effects of glutamine and glutamate on induced hyperpermeability in intestinal cell lines were studied.Paracellular hyperpermeability was induced in Caco2.BBE and HT-29CL.19A cell lines by adding phorbol-12,13-dibutyrate(PDB) apically,after which the effects of glutamine and glutamate on horseradish peroxidase(HRP) diffusion were studied.An inhibitor of glutamate transport(L-trans-pyrrolidine-2,4-dicarboxylic acid:trans-PDC) and an irreversible blocker(acivicin) of the extracellular glutamine to glutamate converting enzyme,γ-glutamyltransferase,were used.RESULTS:Apical to basolateral HRP flux increased significantly compared to controls not exposed to PDB (n=30,P<0.001).Glutamine application reduced hyperpermeability by 19%and 39%in the respective cell lines.Glutamate application reduced hyperpermeability by 30%and 20%,respectively.Incubation of HT29CL.19A cells with acivicin and subsequent PDB and glutamine addition increased permeability levels.Incubation of Caco2.BBE cells with trans-PDC followed by PDB and glutamate addition also resulted in high permeability levels.CONCLUSION:Apical glutamate-similar to glutaminecan decrease induced paracellular hyperpermeability.Extracellular conversion of glutamine to glutamate and subsequent uptake of glutamate could be a pivotal step in the mechanism underlying the protective effect of glutamine. | Mechteld AR Vermeulen Jeffrey de Jong Mathijs J Vaessen Paul AM van Leeuwen Alexander PJ Houdijk | 2011 | World Journal of Gastroenterology2011，17，12： | 9 |
| 4 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 5 | 未控制高血压患者进行家庭血压监测与药剂师管理后的心血管事件及费用显示文摘未控制高血压是心血管病的主要病因。在16家初级保健诊所进行的整群随机试验结果表明:12个月的远程家庭血压监测与药剂师管理可较常规治疗24个月降压幅度更大。该文报道心血管事件(非致死性心肌梗死、非致死性脑卒中、心力衰竭住院、冠状动脉再血管化及心血管病死亡)与随访5年的花费。在远程干预组(TI组,n=228),10例患者发生15次心血管事件(5次心肌梗死、4次脑卒中、5次心力衰竭、1次心血管病死亡)。 | 赵狄(摘译) 刘莉(审校) Margolis KL Dehmer SP Sperl-Hillen J O’Connor PJ Asche SE Bergdall AR Green BB Nyboer RA Pawloski PA Trower NK Maciosek MV | 2020 | 中华高血压杂志2020，28，11： | 3 |
| 6 | 美白牙膏去除牙齿外源性色斑的临床效果观察显示文摘目的 与仅含有 0 .32 1%氟化钠的牙膏相比 ,评价含有 0 .32 1%氟化钠及 2 0 %高清洁二氧化硅 (HCS)的牙膏减少外源性牙色斑的效果。方法 采用双盲、分层、二单位平行观察的临床研究方法。根据Lobene色斑指数均数 (色斑指数包括染色部位及染色程度 )、性别、将 15 8名年龄为 18~ 6 5岁的研究对象平衡地分为两组 ,随机地分配使用试验或对照牙膏。于基线、第 4周及第 8周固定由一名检查者完成研究对象的色斑指数测定。结果 4周时 ,使用美白牙膏的研究对象较对照组的牙齿色斑面积减少 17.4% ,染色程度减少 19.2 % (P <0 .0 1)。 8周时 ,使用美白牙膏的研究对象较对照组的牙齿色斑面积减少 38.6 % ,染色程度减少 39.6 % (P <0 .0 1)。结论 与对照组牙膏相比 ,使用含有 0 .32 1%氟化钠及 2 0 | 李雪 胡德渝 YP Zhang S Miller J Miller ME Petrone W Devizio AR Volpe | 2001 | 广东牙病防治2001，9，3： | 3 |
| 7 | Application of genetic algorithm and simulated annealing technique in optimizing the aperture distributions of antenna array patterns显示文摘 | F J Ares | 1996 | Electronics Letters1996，32，3： | 2 |
| 8 | 地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系显示文摘血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。 | 黄洁 叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 9 | 糖尿病、糖尿病前期与亚临床心肌损害发生率显示文摘众所周知,处于糖尿病前期者和糖尿病患者存在较高的心血管事件发生风险。然而,糖尿病前期和糖尿病与亚临床心肌损害发生间的关系尚不明确。方法与结果:应用高敏心肌肌钙蛋白T (highly sensitive cardiac troponin T hs-cTnT)分析,测定社区动脉粥样硬化风险研究中9331例受试者两个时间点(间隔6年)的心肌肌钙蛋白T(cardiac troponin T,cTnT)水平,所有受试者为无糖尿病或处于糖尿病前期,或糖尿病不伴心血管疾病(包括心电图检测出来的无临床症状的心肌梗死)。 | Selvin E Lazo M Chen Y Shen L Rubin J McEvoy JW Hoogeveen RC Sharrett AR Ballantyne CM Coresh J 刘莉 | 2014 | 中华高血压杂志2014，22，9： | 2 |
| 10 | The role of ultrasonography and automatic-needle biopsy in outpatient percutaneous liver biopsy显示文摘 | KD Lindor C Bru RA Jorgensen J Rakela JM Bordas JB Gross J Rodes DB McGill CC Reading EM James JW Charboneau J Ludwig KP Batts AR Zinsmeister | 1996 | Hepatology1996，，5： | 2 |
| 11 | A reciprocal translocation between ’Garfi’ almond and ’Nemared’ peach显示文摘 | B. Jáuregui M.C. de Vicente R. Messeguer A. Felipe A. Bonnet G. Salesses P. Arús | 2001 | TAG Theoretical and Applied Genetics2001，，8： | 2 |
| 12 | A shunt active power filter applied to high voltage distribution lines显示文摘 | HAFNER J AREDS M HEUMANN K | 1997 | IEEE Trans on Power Delivery1997，12，1： | 1 |
| 13 | Gap junctions containing alpha8-connexin (MP70) in the adult mammalian lens epithelium suggests a re-evaluation of its role in the lens显示文摘 | Dahm R van Marie J Prescott AR | 1999 | Exp Eye Res1999，69，： | 1 |
| 14 | Amyloid beta peptide-induced cholinergic fibres loss in the cerebral cortex of the rat is modified by diet high in lipids and by age显示文摘 | Gonzalo-Ruiz A Sanz J M Arévalo J | 2005 | J Chem Neuroanat2005，29，1： | 1 |
| 15 | Insulin resistance syndrome in childhood:associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors显示文摘 | Sinaiko AR Jacobs DR Jr Steinberger J | 2001 | J Pediatr2001，139，5： | 1 |
| 16 | Differential regulation of EphA2 in nomlal and malignant cells显示文摘 | Walker-Daniels J Hess AR Hendrix M J | 2003 | Am J Pathol2003，162，4： | 1 |
| 17 | Aripiprazoe, an antipsychotic with a novel mechanismof actianwith psychizophrenia and schizoaffective disorder显示文摘 | Potkin SG Saha AR Kujawa M J | 2003 | Arch Gen Psycheiatry2003，60，： | 1 |
| 18 | Association between protein in- take and blood pressure显示文摘 | Elliott P Stamler J Dyer AR | 2006 | Arch Intern Med2006，166，1： | 1 |
| 19 | FHPG positron emission tomography for detection of herpes simplex virus(HSV) in experimental HSV encephalitis显示文摘 | Buursma AR de Vries EF Garssen J | 2005 | J Virol2005，79，12： | 1 |
| 20 | Differential attentional modulation of cortical responses to S-cone and luminance stimuli 显示文摘 | Wang J Wade AR | 2011 | J Vis2011，11，6： | 1 |
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