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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | Using on-site liver 3-D reconstruction and volumetric calculations in split liver transplantation显示文摘BACKGROUND: Split liver transplantation increases the number of grafts available for transplantation. Pre-recovery assessment of liver graft volume is essential for selecting suitable recipients. The purpose of this study was to determine the ability and feasibility of constructing a 3-D model to aid in surgical planning and to predict graft weight prior to an in situ division of the donor liver. METHODS: Over 11 months, 3-D volumetric reconstruction of 4 deceased donors was performed using Pathfinder Scout~? liver volumetric software. Demographic, laboratory, operative, perioperative and survival data for these patients along with donor demographic data were collected prospectively and analyzed retrospectively.RESULTS: The average predicted weight of the grafts from the adult donors obtained from an in situ split procedure were 1130 g(930-1458 g) for the extended right lobe donors and 312 g(222-396 g) for left lateral segment grafts. Actual adult graft weight was 92% of the predicted weight for both the extended right grafts and the left lateral segment grafts. The predicted and actual graft weights for the pediatric donors were 176 g and 210 g for the left lateral segment grafts and 308 g and 280 g for the extended right lobe grafts, respectively. All grafts were transplanted except for the right lobe from the pediatric donors due to the small graft weight.CONCLUSIONS: On-site volumetric assessment of donors provides useful information for the planning of an in situ split and for selection of recipients. This information may expand the donor pool to recipients previously felt to be unsuitable due to donor and/or recipient weight. | Trevor W Reichman Brittany Fiorello Ian Carmody Humberto Bohorquez Ari Cohen John Seal David Bruce George E Loss | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，6： | 2 |
| 3 | Plant responses to drought, salinity and extreme temperatures towards genetic engineering for stress tolerance 显示文摘 | Wang W Vinocur Basia Altman Arie | 2003 | Planta2003，，： | 1 |
| 4 | Mineral absorption and excretion as affected by microbial phytase,and their effect on energy metabolism in young piglets 显示文摘 | Arie K K Walter J J G Johan W S | 2005 | J Nutr2005，135，： | 1 |
| 5 | Baseline metals pollution profile of tropical estuaries and coastal waters of the Straits of Malacca显示文摘 | Looi L J Aris A Z Johari W L W | 2013 | Marine Pollution Bulletin2013，74，1： | 1 |
| 6 | Fault-induced polytypism in (Cr, Fe)2B 显示文摘 | Goldfarh I Kaplan W D Ariely S | 1995 | Philosophical Magazine A1995，72，4： | 1 |
| 7 | The effects of fill strategies on SBR performance under nitrogen deficiency and rich conditions显示文摘 | SHEKER R E ARIS R M SHIEH W K | 1993 | Wat Sci Tech1993，28，10： | 1 |
| 8 | Transient electromagnetic fields due to switching operations in electric power systems显示文摘 | ARI N BLUMER W | 1987 | IEEE Transactions on Electromagnetic Compatibility1987，29，3： | 1 |
| 9 | Effects of exercise training on vascularfunctionin obese children显示文摘 | Katie W Petra B Aris S | 2004 | J Pediatrics2004，144，5： | 1 |
| 10 | Convergence Analysis of LMS Filters With Uncorrelated Gaussian Data 显示文摘 | Arie F Ehud W | 1985 | IEEE trans on signal processing1985，33，1： | 1 |
| 11 | Effect of fullerene coating on silicon thin film anodes for lithium rechargeable batteries 显示文摘 | ARIE A A CHANG W Y LEE J K | 2010 | J Solid State Electrochemistry2010，14，： | 1 |
| 12 | 显示文摘 | Carr Robert W Aris Rutherford | 1993 | Science1993，262，： | 1 |
| 13 | Analysis of cell wall components in juice of flavortop nectarines during normal ripening and woolliness 显示文摘 | Zhou H W Sonego L Ben- Arie R | 1999 | Journal of the American Society for Horticultural Science1999，124，4： | 1 |
| 14 | Obliterative bronchiolitis or chronic lung allograft rejection-A basic science review显示文摘 | Neuringer IP Chalermskulrat W Aris R | 2005 | Heart Lung Transplant2005，24，1： | 1 |
| 15 | Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II显示文摘 | Vasim Farooq David van Klaveren Ewout W Steyerberg Emanuele Meliga Yvonne Vergouwe Alaide Chieffo Arie Pieter Kappetein Antonio Colombo David R Holmes Michael Mack Ted Feldman Marie-Claude Morice Elisabeth St?hle Yoshinobu Onuma Marie-angèle Morel Hector | 2013 | The Lancet2013，，9867： | 1 |
| 16 | 1 Molecular phy logeny of D ipterocarpaceae in Southeast Asia using RFLP o f PCR amplified ch 1o roplast genes显示文摘 | Tsum ura Y K aw ahara T W icknesw ari R et a | 1996 | The oredcal and Applied Genetics1996，，93： | 1 |
| 17 | Bioequivalence among three methods of administering pantoprozole granules in healthy subjects显示文摘 | BRINDA T KATHY W ARIE K | 2009 | Am J Health Syst Pharm2009，66，21： | 1 |
| 18 | Simulation of the development of deformation textures and residual stresses using the Taylor-Bishop-Hill theory显示文摘 | ARIS S PYZALLA A REIMERS W | 1999 | Computational Materials Science1999，16，14： | 1 |
| 19 | Isoelectric precipitation of soybean protein using carbon dioxide as a volatile acid显示文摘 | Gerard W Hofland Aris de Rijke Russell Tniering | 2000 | Journal of Chromatogaphy B2000，743，： | 1 |
| 20 | One year follow-up of the multicentre European PARTNER transcatheter heart valve study显示文摘 | Thierry L Ari P Ernst W etal | 2011 | Eur Heart J2011，32，2： | 1 |
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