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| 1 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 2 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 3 | Geophysical investigations of large landslides in the Carnic Region of southern Austria显示文摘 | Mauritsch H J Seiberl W Arndt R | 2000 | Engineering Geology2000，56，34： | 2 |
| 4 | Quantitative analysis of an- aerobic oxidation of methane ( AOM ) in marine sediments : A modeling perspective显示文摘 | Regnier P Dale A W Arndt S | 2011 | Earth-Science Reviews2011，106，12： | 1 |
| 5 | Globslization and the Open Economy显示文摘 | Arndt Sven W | 1997 | North American Journal of Economics and Finance1997，8，1： | 1 |
| 6 | injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations显示文摘 | Klement W Arndt JO Pain on IV | 1991 | Br J Anaesth1991，66，2： | 1 |
| 7 | Use of decreasing foliar carbon isotope dis crimination during water limitation as a carbon tracer to study whole plant carbon allocation显示文摘 | Arndt S K Wanek W | 2002 | Plant Cell and Environment2002，25，： | 1 |
| 8 | Gene Order Phylogeny of the Genus Prochlorococcus显示文摘 | Luo H Shi J Arndt W | 2008 | PLoS ONE2008，3，12： | 1 |
| 9 | Effects of heat treatment and substitution level on palatability and nutritional value of soy defatted flour in feeds for coho salmon, Oncorhynchus Kisutch I显示文摘 | Arndt R E Hardy R W Sugiura S H | 1999 | Aquaculture1999，180，： | 1 |
| 10 | Globalization and the Open Economy显示文摘 | Arndt Sven W | 1997 | North American Joumal of Economics and Finance 81997，，： | 1 |
| 11 | Force Response during Tire Tread Detachment Event 显示文摘 | ARNDT M W ROSENFIELD M J ARNDT S M | 2004 | Society of Automotive Engineers Transactions2004，113，6： | 1 |
| 12 | Pain on injection of propofol: effects of concentration and diluent显示文摘 | Arndt JO | 1991 | Bri J Anaesthesia1991，67，： | 1 |
| 13 | Critical review of psycho-social interventions in cancer care显示文摘 | Fawzy F I Fawzy N W Arndt L A | 1995 | Arch Gen Psychiatry1995，52，2： | 1 |
| 14 | Vehicle Handling with Tire Tread Separation 显示文摘 | DICKERSON C P ARNDT M W ARNDT S M | 1999 | Society of Automotive Engineers Transactions1999，108，6： | 1 |
| 15 | Nobel metal abundances in Komatiite suites from Alexo, Ontario and Gorgona Island, Colombia显示文摘 | Briigmann G E Arndt N T Hofi'nann A W | 1987 | Geochimica et Cosmochimica Acta1987，51，： | 1 |
| 16 | Globalization and the Open Economy 显示文摘 | Arndt S W | 1997 | North American Journal of Economics and Finance1997，8，1： | 1 |
| 17 | Geophysical investigations of large landslides in the Carnic Region of Southern Austria 显示文摘 | Mauritsch H J Seiberl W Arndt R | 2000 | Engineering Geology2000，56，34： | 1 |
| 18 | Super-specialization and the Gains from Trade显示文摘 | Arndt S W | 1998 | Contem-porary Economic Policy1998，16，4： | 1 |
| 19 | The impact of patient and tumour baseline characteristics on the overall survival of patients with advanced hepatocellular carcinoma treated with sorafenib显示文摘 | Marcus A. W?rns Sandra Koch Ina M. Niederle Jens U. Marquardt Marc Nguyen-Tat Thomas Gamst?tter Marcus Schuchmann Henning Schulze-Bergkamen Peter R. Galle Arndt Weinmann | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 20 | Replication of a scenic preference function显示文摘 | BuhyoffG J Leuschner W A Arndt L K | 1980 | For Sci1980，26，2： | 1 |
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