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| 1 | microRNAs: Fad or future of liver disease显示文摘microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors. miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools. | Ashley M Lakner Herbert L Bonkovsky Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 13 |
| 2 | Lung cancer screening: Should we be excluding people with previous malignancy?显示文摘The National Lung Screening Trial(NLST) was a large,randomized, controlled study showing a 20% reduction of lung cancer mortality and 7% reduction of all cause mortality using annual low dose computed tomography(LDCT) in a high risk population. NLST excluded people with a previous history of cancer treatment within the past 5 years and all people with a history lung cancer. The aim of this work is to review how lung cancer screening trials addressed the confounding effect of previous malignancy. We also review the subsequent recommendations by the United States Preventative Task Force Services, multiple professional societies and the Center for Medicaid and Medicare Services which defer either to NLST criteria or, clinician judgment or refrain from asserting any recommendation on the topic, respectively. Implications of lung cancer screening in the setting of previous malignancies, specifically lung, head and neck, esophageal, gastric, breast, colorectal cancer and lymphoma are also discussed. With lung cancer screening, an antecedent malignancy introduces the possibility of discovering metastasis as well as lung cancer. In some circumstances diagnosis and treatment of oligometastatic disease may confer a survival benefit. The survival benefit of treating either lung cancer or oligometastatic disease as result of lung cancer screening has yet to be determined. Further studies are needed to determine the role of lung cancer screening in the setting of previous malignancy. | Cherie P Erkmen Larry R Kaiser Ashley L Ehret | 2016 | World Journal of Respirology2016，6，1： | 2 |
| 3 | Tmmunohistochemical distrbution of C-erbB-2 in situ breast carcinoma dedailed morphological analysis 显示文摘 | 11,Ramachandra S Machin L Ashley S | 1990 | J1990，161，1： | 1 |
| 4 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 5 | Discrimination of hydrothermally altered rocks and unaltered rocks in visible and near infrared multi- spectral images显示文摘 | ROWAN L C GOETZ A F H ASHLEY R P | 1977 | Geophysics1977，42，3： | 1 |
| 6 | Determination of 10 carcinogenic polyeyclic aromatic hydrocarbons in mainst-ream cigarette smoke显示文摘 | Ding Y S Ashley D L Watson C H | 2007 | J Agri & Food Chem2007，55，： | 1 |
| 7 | Reproducibility of the Spectral Components of the Electroencephalogram during Driver Fatigue显示文摘 | Saroj K L Lal Ashley Craig | 2005 | International Journal of Psy- chophysiology2005，55，2： | 1 |
| 8 | Analysis of volatile organic compounds in mainstream cigarette smoke显示文摘 | Polzin G M Kosa-Maines R E Ashley D L | 2007 | Environmental Science & Technology2007，41，4： | 1 |
| 9 | Improving the safety of chemo- therapy administration:An oncology nurse failure mode and effects a- nalysis显示文摘 | Ashley L Dexter R Marshall F | 2011 | Oncol Nurs For2011，38，6： | 1 |
| 10 | Translation and protein synthesis:macrolides显示文摘 | Katz L Ashley G W | 2005 | Chem Rev2005，105，2： | 1 |
| 11 | Immunohistochemical distribution of C-erbB-2 in insitu breast carcinoma-a detailed morphological analysis显示文摘 | Ramachandra S Machin L Ashley S | 1990 | J Pathol1990，161，1： | 1 |
| 12 | Methods for Researching Gear Whine in Automotive TransaxIes显示文摘 | ASHLEY L D DONALD R H | 1997 | SAE1997，，1： | 1 |
| 13 | Double-blind,placebo-controlled trial of a herpes simplex virus type 2 glycoprotein vaccine in persons at high risk for genital herpes infection显示文摘 | MERTZ G J ASHLEY R BURKE R L | 1990 | J Infect Dis1990，161，4： | 1 |
| 14 | Influence of top- ping and side pruning on cotton yield and other characteristics显示文摘 | BENNETT O L Ashley D A Doss B D | 1965 | Agronomy Journal1965，67，： | 1 |
| 15 | Population dynamics of a meiotic/mitotic expansion model for the fr-agile X syndrome显示文摘 | Ashley A E Sherman S L | 1995 | Am J Hum Genet1995，57，6： | 1 |
| 16 | Evaluatian and competitive tendering of Laibin B power plant project in China 显示文摘 | Wang S Q Tiong R L K Ting S K Chew D and Ashley D | 1998 | Journal of Construction Engineering and Management1998，124，4： | 1 |
| 17 | Using the blood concentration of 2, 5 - dimethylfuran as a marker for smoking显示文摘 | Ashley D L Bonin M A Hamar B | 1996 | International Archives of occupational and Environmental Health1996，68，3： | 1 |
| 18 | Failure Mode and Effects Analy sis:an empirical comparison of failure mode scoring pro cedures显示文摘 | Ashley L Armitage G | 2010 | J Pat Saf2010，6，4： | 1 |
| 19 | Supercritical fluid extraction and gas chromatography/mass spectrometry for the analysis of tobacco-specific nitrosamines in cigarettes显示文摘 | Song S Ashley D L | 1999 | Anal Chem1999，71，： | 1 |
| 20 | Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin显示文摘 | Moser T L Kenan D J Ashley TA | 2001 | Proc Natl Acod Sci USA2001，98，12： | 1 |
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