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| 1 | Hepatitis B and C virus reactivation in immunosuppressed patients with inflammatory bowel disease显示文摘In recent years,a number of case reports and clinical studies have highlighted the risk of hepatitis B and C virus reactivation in patients with inflammatory bowel disease who are treated with immunosuppressive drugs.The cases of viral hepatitis reactivation that have been reported are characterized by a wide range of clinical manifestations,from viremia without clinically relevant manifestations to fulminant life-threatening hepatitis.The development and dissemination of biological immunosuppressive drugs have led to a significant increase in the number of reports of interest to physicians in a variety of clinical settings.On this topic,there have been a number of published guidelines and reviews that have collected the available evidence,providing recommendations on prophylactic and therapeutic strategies and methods for monitoring patients at risk.However,it should be noted that,to date,very few clinical studies have been published,and most of the recommendations have been borrowed from otherclinical settings.The published studies are mostly retrospective and are based on very heterogeneous populations,using different therapeutic and prophylactic regimens and obtaining conflicting results.Thus,it seems clear that it is desirable to concentrate our efforts on prospective studies,not conducting further reviews of the literature in the continued absence of new evidence. | Stefano Sansone Maria Guarino Fabiana Castiglione Antonio Rispo Francesco Auriemma Ilaria Loperto Matilde Rea Nicola Caporaso Filomena Morisco | 2014 | World Journal of Gastroenterology2014，20，13： | 6 |
| 2 | Sustained virological response: A milestone in the treatment of chronic hepatitis C显示文摘AIM: To evaluate the long-term eradication of hepatitis C virus (HCV) infection and liver-related complications in chronically infected patients that have achieved sustained virological response. METHODS: One hundred and fifty subjects with chronic hepatitis C (CHC) or cirrhosis and sustained virological response (SVR) between the years of 1989 and 2008 were enrolled in a long-term clinical follow-up study at the Gastrointestinal and Liver Unit of the University Hospital of Naples 'Federico Ⅱ'. At the beginning of the study, the diagnosis of HCV infection was made on the basis of serum positivity for antibodies to HCV and detection of HCV RNA transcripts, while a diagnosis of chronic hepatitis was formulated using imaging techniques and/or a liver biopsy. SVR was achieved by interferon-based therapy, both conventional and pegylated, with and without ribavirin treatment. The patients were evaluated for follow-up at a median length of 8.6 years, but ranged from 2-19.9 years. Among them, 137 patients had pre-treatment CHC and 13 had cirrhosis. The patients were followed with clinical, biochemical, virological, and ultrasound assessments on a given schedule. Finally, a group of 27 patients underwent a liver biopsy at the beginning of the study and transient elastography at their final visit to evaluate changes in liver fibrosis. RESULTS: The median follow-up was 8.6 years (range 2-19.9 years). HCV RNA remained undetectable in all patients, even in patients who eventually developed liver-related complications, indicating no risk of HCV recurrence. Three liver-related complications were observed: two cases of hepatocellular carcinoma and one case of bleeding from esophageal varices resulting in an incidence rate of 0.23%/person per year. Further, all three complications took place in patients diagnosed with cirrhosis before treatment began. Only one death due to liver-related causes occurred, resulting in a mortality rate of 0.077% person per year. This amounts to a 99.33% survival rate in our cohort of patients after therapy for HCV infection. Finally, of the 27 patients who underwent a liver biopsy at the beginning of the study, a reduction in liver fibrosis was observed in 70.3% of the cases; only three cases registering values of liver stiffness indicative of significant fibrosis. CONCLUSION: Patients with CHC and SVR show an excellent prognosis with no risk of recurrence and a very low rate of mortality. Our data indicate that viruseradication following interferon treatment can last up to 20 years. | Filomena Morisco Rocco Granata Tommaso Stroffolini Maria Guarino Laura Donnarumma Laura Gaeta Ilaria Loperto Ivan Gentile Francesco Auriemma Nicola Caporaso | 2013 | World Journal of Gastroenterology2013，19，18： | 4 |
| 3 | Radiofrequency and malignant biliary strictures:An update显示文摘Malignant biliary strictures are usually linked to different types of tumors,mainly cholangiocarcinoma, pancreatic and hepatocellular carcinomas. Palliative measures are usually adopted in patients with nonresectable or borderline resectable biliary disease. Stent placement is a well-known and established treatment in patients with unresectable malignancy. Intraductal radiofrequency ablation(RFA) represents a procedure that involves the use of a biliary catheter device, via an endoscopic approach. Indications for biliary RFA described in literature are: Palliative treatment of malignant biliary strictures, avoiding stent occlusion, ablating ingrowth of blocked metal stents, prolonging stent patency,ablating residual adenomatous tissue after endoscopic ampullectomy. In this mini-review we addressed focus on technical success defined as deployment of the RF catheter, virtually succeeded in all patients included in the studies. About efficacy, three main outcome measures have been contemplated: Biliary decompression and stent patency, survival. Existing studies suggest a beneficial effect on survival and stent patency with RFA, but current impression is limited because most of studies have been performed using a retrospective design, on diminutive and dissimilar cohorts of patients. | Francesco Auriemma Luca De Luca Mario Bianchetti Alessandro Repici Benedetto Mangiavillano | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，2： | 3 |
| 4 | Pancreatoscopy: An update显示文摘Per-oral pancreatoscopy(POPS) is an endoscopic procedure to visualize the main pancreatic duct. POPS specifically has the advantage of direct visualization of the pancreatic duct, allowing tissue acquisition and directed therapies such as stones lithotripsy. The aim of this review is to analyze and summarize the literature around pancreatoscopy. Pancreatoscopy consists of the classic technique of the mother-baby method in which a mini-endoscope is passed through the accessory channel of the therapeutic duodenoscope. Pancreatoscopy has two primary indications for diagnostic purpose. First, it is used for visualization and histological diagnosis of intraductal papillary mucinous neoplasms. In these cases, POPS is very useful to assess the extent of malignancy and for the study of the intraductal papillary mucinous neoplasm in order to guide the surgery resection margins. Second, it is used to determine pancreatic duct strictures,particularly important in cases of chronic pancreatitis, which is associated with both benign and malignant strictures. Therefore POPS allows differentiation between benign and malignant disease and allows mapping the extent of the tumor prior to surgical resection. Also tissue sampling is possible, but it can be technically difficult because of the limited maneuverability of the biopsy forceps in the pancreatic ducts. Pancreatoscopy can also be used for therapeutic purposes, such as pancreatoscopy-guided lithotripsy in chronic painful pancreatitis with pancreatic duct stones. The available data for the moment suggests that, in selected patients, pancreatoscopy has an important and promising role to play in the diagnosis of indeterminate pancreatic duct strictures and the mapping of main pancreatic duct intraductal papillary mucinous neoplasms. However, further studies are necessary to elucidate and validate the pancreatoscopy role in the therapeutic algorithm of chronic pancreatitis. | Luca De Luca Alessandro Repici Adea Ko?ollari Francesco Auriemma Mario Bianchetti Benedetto Mangiavillano | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，1： | 2 |
| 5 | Structural Disorder in the a Foam of Isotactic Polypropylene 显示文摘 | Auriemma | 2000 | Macromolecules2000，11，23： | 1 |
| 6 | A new mesophase of isotactic polypropylene in copolymers of propylene with long branched comonomers 显示文摘 | De Rosa C Auriemma F Di Girolamo R | 2010 | Macromolecules2010，43，20： | 1 |
| 7 | 查看详情显示文摘 | De Rosa C Auriemma F Di Capua A Resconi L. Guidotti S. Camurati I. Nifant'ev I.E.and Laishevtsev I.P | | 0，，： | 1 |
| 8 | 查看详情显示文摘 | De Rosa C Auriemma F De Lucia G Resconi L | | 0，，： | 1 |
| 9 | Mechanism of leptin ex- pression in breast cancer ceils: role of hypoxia-inducible factor-1alpha显示文摘 | Cascio S Bartella V Auriemma A | 2008 | Oncogene2008，27，4： | 1 |
| 10 | Circulating levels of soluble intercellular adhesion molecule-1 in non-small cell lung cancer patients显示文摘 | De-vita F lnfusino S Auriemma A | 1998 | Oncol Rep1998，5，2： | 1 |
| 11 | Pituitary tumors and pregnancy:the interptaybetween a pathologic con- dition and a physiologic status显示文摘 | Pivonello R De Martino MC Auriemma RS | 2014 | J Endocrinol Invest2014，37，： | 1 |
| 12 | The pathophysiology of cardiac surgery-associated acute kidney injury(CSA-AKI)显示文摘 | Bellomo R Auriemma S Fabbri A | 2008 | Int J Artif Organs2008，31，2： | 1 |
| 13 | Dry powder inhalers of gentamicin and leucine: formulation parameters, aerosol performance and in vitro toxicity on CuFil cells显示文摘 | Aquino RP Prota L Auriemma G | 2012 | Int J Pharm2012，426，12： | 1 |
| 14 | Mechanical properties of syndiotactic propylene-ethylene copolymers显示文摘 | Auriemma Cdrf | 2006 | Macromolecules2006，39，1： | 1 |
| 15 | Cytokines and T cellsin atopic dermatitis显示文摘 | Auriemma M Vianale G Amerio P | 2013 | Eur Cytokine Netw2013，24，1： | 1 |
| 16 | Invasive breast cancer:Ki-67 evaluation in 3909 early breast cancer patients显示文摘 | Auriemma A Mercanti A Fiorio E | 2005 | ASCO Meeting Abstracts2005，23，16： | 1 |
| 17 | Synthesis and ring-opening metathesis polymerization of norbornene- terminated syndiotaetie polypropylene显示文摘 | Anderson-Wile A M Coates G W Auriemma F | 2012 | Macromolecules2012，45，19： | 1 |
| 18 | Pituitary carcinomas显示文摘 | Colao A Ochoa AS Auriemma RS | 2010 | Front Horm Res2010，38，： | 1 |
| 19 | Patulin in homogenized fruit's and tomato products显示文摘 | Sarubbi F Formisano G Auriemma G | 2016 | Food Control2016，，59： | 1 |
| 20 | Invasive breast cancer: ki67 evaluation in 3909 early breast cancer patients显示文摘 | Auriemma A Mercanti A Fiorio E | 2005 | ASCO Meeting Abstracts2005，23，16： | 1 |
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