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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | Penetration of solids and biological activity into slow sand filters显示文摘 | Ellis K V Aydin M E | 1995 | Water Research1995，29，： | 2 |
| 3 | Combined impact of matrix metalloproteinase-3 and paraoxonase 1 55/192 gene variants on coronary artery disease in Turkish patients 显示文摘 | Ozktik E Aydin M Babalik E | 2008 | Med Sci Monit2008，14，10： | 1 |
| 4 | Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine,folate and vitamin B12 in coronary artery disease显示文摘 | Aydin M Gokkusu C Ozkok E | | 0，，02： | 1 |
| 5 | Evolution of a strike-slip fault network, Valley of Fire State Park, southern Nevada显示文摘 | Flodin E A Aydin A | 2004 | GSA Bulletin January2004，116，： | 1 |
| 6 | Decreased HDL-de- pendent paraoxonase and arylesterase enzyme activity May indicate a worse prognosis in multiple myeloma显示文摘 | Ellidag HY Aydin O Eren E | 2014 | Asian Pac J Cancer Prev2014，15，22： | 1 |
| 7 | Non-dipper hypertension is associated with slow coronary flow among hypertensives with normal coronary angiogram显示文摘 | Aksit E Gursul E Aydin F | 2016 | Cardiovasc J Afr2016，27，： | 1 |
| 8 | Composites piezoelectric transducer with truncated conical endcaps ' Cymbal ' 显示文摘 | Kenji U Robert E Newnham | 1997 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control1997，44，3： | 1 |
| 9 | An adaptive artificial immune system for fault classification 显示文摘 | Aydin I Karakose M Akin E | 2012 | Journal of Intelligent Manufacturing (S0956-5515)2012，23，5： | 1 |
| 10 | Blue but not red light stimulation in the dark has antidepressant effect in behavioral despair 显示文摘 | Iyilikci O Aydin E Canbeyli R | 2009 | Behavioural Brain Research2009，203，1： | 1 |
| 11 | Isola spinal instrumentation system for idiopathic scoliosis显示文摘 | Akalin S Aydin E | 2001 | Arch Orthop Trauma Surg2001，121，12： | 1 |
| 12 | Relationship BetweenSerum BDNF Levels and Cognitive Functions·Cortisol Levelsin Depressive Disorder显示文摘 | Sozeri-Varma G Enli Y Aydin E | 2012 | Journal of Mood Disorders2012，2，2： | 1 |
| 13 | Three di- mensional visualization of normal fault segmentation and its implication for fault growth显示文摘 | KOLEDOYE A K AYDIN A MAY E | 2000 | The Leading Edge2000，19，7： | 1 |
| 14 | Long-term outcomes and prognostic factors of patients with surgically treated pulmonary carcinoid : our institutional experience with 104 patients 显示文摘 | Aydin E Yazici U Gulgosteren M | 2011 | Eur J Cardiothorac Surg2011，39，4： | 1 |
| 15 | Capacitor-loaded split ring resonators as tunable metamaterial components显示文摘 | Aydin K Ozbay E | 2007 | J Appl Phys2007，101，24： | 1 |
| 16 | A distributed evolution- ary simulated annealing algorithm for combinatorial op- timisation problems 显示文摘 | AYDIN M E FOGARTY T C | 2004 | Journal of Heuristics2004，10，3： | 1 |
| 17 | T-cell lymphoblastic lymphoma presenting with a breast mass显示文摘 | Yumuk PF Aydiner A Topuz E | | 0，，04： | 1 |
| 18 | Theeffects of G-CSF and naproxen sodium on the serum TGF-betal level and fracture healing in rat tibias显示文摘 | KAYGUSUZ M A TURAN C C AYDIN N E | 2006 | Life Sci2006，80，1： | 1 |
| 19 | The impact of the D727epolymorphism has no significant role in multi nodulargoiter显示文摘 | Tug E Sengiil N Aydin H al | 2012 | Balkan J Med Genet2012，15，： | 1 |
| 20 | Comparison of surgical outcomes of endonasal dacryocystorhinostomy with or without mucosal flaps显示文摘 | Kansu L Aydin E Avci S | 2009 | Auris Nasua Larynx2009，36，5： | 1 |
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