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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | WONCA研究论文摘要汇编--老年亚临床甲状腺功能减退治疗策略的国际变化趋势:一项基于案例的调查显示文摘背景关于亚临床甲状腺功能减退治疗效果的证据十分有限,特别是对于老年患者的治疗效果。目的探讨全科医生在不同国家和针对不同类型的患者对老年亚临床甲状腺功能减退治疗的不同方式。设计和环境在荷兰、德国、英格兰、爱尔兰、瑞士和新西兰进行基于案例的全科医生调查。方法评估全科医生对于8例表现为亚临床甲状腺功能减退患者的治疗策略(治疗是/否,起始剂量甲状腺素)。患者的特征如年龄(70岁与85岁),活力状态(充满活力与脆弱)和促甲状腺激素(TSH)浓度(6 m U/L与15 m U/L)均有差异。结果共有526名全科医生参与此项研究(瑞士262名、荷兰129名、德国61名、新西兰31名、英格兰22名、爱尔兰21名,总有效率为19%)。不同国家的治疗策略会有所不同。相比较于来自德国(平均治疗比例为73%)、爱尔兰(平均治疗比例为62%)和瑞士(平均治疗比例为52%)的全科医生,来自荷兰(平均治疗比例为34%)、英格兰(平均治疗比例为40%)和新西兰(平均治疗比例为39%)的全科医生更加不倾向于实施治疗(P=0.05)。总体来讲,全科医生更倾向于对70岁的女性患者实施治疗,而不是85岁的女性患者〔比值比=0.74,95%CI(0.63,0.87)〕。TSH为15 m U/L的患者比TSH为6m U/L的患者更易于得到治疗〔比值比=9.49,95%CI(5.81,15.5)〕。结论全科医生对于不同国家和不同类型的老年亚临床甲状腺功能减退患者的治疗策略有很大差异,而这种差异说明有必要建立新一代基于初级卫生医疗随机临床试验的国际指南。 | den Elzen WP Lefèbre-van de Fliert AA Virgini V 周淑新 | 2015 | 中国全科医学2015，18，12： | 4 |
| 3 | Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury显示文摘 | Brocheriou V Hagege AA Oubenaissa A | 2000 | J Gene Med2000，2，5： | 2 |
| 4 | Visualizing the kinetics of tumor-cell clearance in living animals显示文摘 | Sweeney T J Mailander V Tucker AA | 1999 | Proc Natl Acad Sci USA1999，96，12： | 1 |
| 5 | Serum S100beta: a noninvasive marker of blood-brain barrier function and brain lesions 显示文摘 | Kanner AA Marchi N Fazio V | 2003 | Cancer2003，97，11： | 1 |
| 6 | β blocker effects on postoperative atrial fibrillation显示文摘 | Ali IM Sanalla AA Clark V | 1997 | Eur J Cardio-thoracic Surg1997，11，： | 1 |
| 7 | Cardiac functional improvement by a human Bcl-2transgene in a mouse model of ischemia/reperfusion injury显示文摘 | Brocheriou V Hagege AA Oubenaissa A | 2000 | J Gene Med2000，2，5： | 1 |
| 8 | Autoset nasal CPAP titration: constancy of pressure, compliance and effectiveness at 8 month follow - up显示文摘 | Teschler H Farhat AA Exnsr V | 1997 | Eur Respir J1997，10，19： | 1 |
| 9 | Serum s100beta:a noninvasive maker of blood-brain barrier function and brain lesions显示文摘 | KANNER AA MARCHI N FAZIO V | 2003 | Cancer2003，97，11： | 1 |
| 10 | Serum S100 beta:a noninvasive marker of blood-brain barrier function and brain lesion显示文摘 | Kanner AA Marchi N Fazio V | 2003 | Cancer2003，97，11： | 1 |
| 11 | Alterations in the virulence potential of enteric pathogens and bacterial-host cell interactions under simulated microgravity conditions显示文摘 | Chopra V Fadl AA Sha J | | 0，，14： | 1 |
| 12 | Mechanical ventilation-in- duced apoptosis in newborn rat lung is mediated via Fasl/Fas pathway显示文摘 | Kroon AA Delriccio V Tseu I | 2013 | Am J Physiol Lung Cell Mol Physiol2013，305，11： | 1 |
| 13 | Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury显示文摘 | Brocheriou V Hagege AA Oubenaissa A | 2000 | J Gene Med2000，2，： | 1 |
| 14 | Physics and engineering of singlet delta oxygen production in low-temperature plasma显示文摘 | Ionin AA Kochetov I V Napartovich A P | 2007 | Journal of Applied Physics2007，40，2： | 1 |
| 15 | Microbubble-enhanced hemorrhage control using high intensity focused ultrasound显示文摘 | Zderic V Brayman AA Sharar SR | 2006 | Ultrasonics2006，45，： | 1 |
| 16 | Vascularendothelial growth factor gene polymorphisms are associated with acute renal allograft re- jection显示文摘 | Shahbazi M Fryer AA Praviea V | 2002 | J Am Soc Neptul2002，13，1： | 1 |
| 17 | Ant colony optimization algo- rithms for solving transportation problems 显示文摘 | Kazharov AA Kureichik V | 2010 | Journal of Computer and Systems Sciences International2010，49，1： | 1 |
| 18 | Serum S100 beta: a noninvasive marker of blood-brain barrier function and brain lesions 显示文摘 | Kanner AA Marchi N Fazio V | 2003 | Cancer2003，97，11： | 1 |
| 19 | Four independent mu- tations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats 显示文摘 | Kehler J S David V A Schaffer AA | 2007 | J Hered2007，98，6： | 1 |
| 20 | TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites显示文摘 | Sultan AA Thathy V Frevert U | 1997 | Cell1997，90，3： | 1 |
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