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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 3 | Characterisation and seasonal variations of particles in the atmosphere of rural, urban and industrial areas:Organic compounds显示文摘Atmospheric aerosol samples(PM_(2.5–0.3), i.e., atmospheric particles ranging from 0.3 to2.5 μm) were collected during two periods: spring–summer 2008 and autumn–winter 2008–2009, using high volume samplers equipped with cascade impactors. Two sites located in the Northern France were compared in this study: a highly industrialised city(Dunkirk) and a rural site(Rubrouck). Physicochemical analysis of particulate matter(PM) was undertaken to propose parameters that could be used to distinguish the various sources and to exhibit seasonal variations but also to provide knowledge of chemical element composition for the interpretation of future toxicological studies. The study showed that PM2.5–0.3concentration in the atmosphere of the rural area remains stable along the year and was significantly lower than in the urban or industrial ones, for which concentrations increase during winter.High concentrations of polycyclic aromatic hydrocarbons(PAHs), dioxins, furans and dioxin like polychlorinated biphenyls(DL-PCBs), generated by industrial activities, traffic and municipal wastes incineration were detected in the samples. Specific criteria like Carbon Preference Index(CPI) and Combustion PAHs/Total PAHs ratio(CPAHs/TPAHs) were used to identify the possible sources of atmospheric pollution. They revealed that paraffins are mainly emitted by biogenic sources in spring–summer whereas as in the case of PAHs, they have numerous anthropogenic emission sources in autumn-winter(mainly from traffic and domestic heating). | Fabrice Cazier Paul Genevray Dorothée Dewaele Habiba Nouali Anthony Verdin Frédéric Ledoux Adam Hachimi Lucie Courcot Sylvain Billet Saad Bouhsina Pirouz Shirali Guillaume Garcon Dominique Courcot | 2016 | Journal of Environmental Sciences2016，28，6： | 4 |
| 4 | Principal component analysis of dissolution data with missing elements显示文摘 | Adams E Walczak B Vervaet C Risha P G Massart D L | 1997 | Chemometrics and intelligent aboratory systems1997，，32： | 2 |
| 5 | A frequency domain method for estimating the parameters of a non-linear structural dynamic model through feedback显示文摘 | D E Adams R J Allemang | 2000 | Mechanical Systems and Signal Processing2000，14，4： | 1 |
| 6 | Changes in the epidemiolngic profile of sudden infant death syndrome as rates decline among California infants:1990-1995显示文摘 | Adams E J Chavez G F Steen D | 1998 | Pediatrics1998，102，6： | 1 |
| 7 | The sequence of the human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，： | 1 |
| 8 | Classification of multispectral images based on fractions of endmembers:Application to land-cover change in the Brazilian Amazon显示文摘 | Adams J B Sabol D E Kapos V | 1995 | Remote Sensing of Environment1995，52，2： | 1 |
| 9 | Maintenance of neuroepi-thelial progenitor cells by Delta-Notch signalling in the embryonicchick retina显示文摘 | Henrique D Hirsinger E Adam J | 1997 | Curr Biol1997，7，： | 1 |
| 10 | Central pontinemyelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients 显示文摘 | Adams R D Victor M Mancall E L | 1959 | AMA Arch Neurol Psychiatry1959，81，4： | 1 |
| 11 | Model estimates of CO2 emissions from soil in response to global warming显示文摘 | Jenkinson D S Adams D E Wild A | 1991 | Nature1991，351，： | 1 |
| 12 | The sequence of human genome显示文摘 | Venter J C Adams M D Myers E W | 2001 | Science2001，291，5507： | 1 |
| 13 | ACC/AHA2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction显示文摘 | Anderson J L Adams C D Antman E M | 2007 | Journal of the American College of Cardiology2007，50，7： | 1 |
| 14 | Recruitment Order of Motor Units in Human Vastus Lateralis Muscle Is Maintained during Fatiguing Contractions 显示文摘 | ADAM A D E LUCA C | 2003 | Neurophysiol2003，90，： | 1 |
| 15 | Angiogenetic protooncogene ets - 1 induced neovascularization is involved in the metastatic process of testicular germ cell tumors显示文摘 | Adam M Schmidt D Wardelmann E | 2003 | Eur Urol2003，44，3： | 1 |
| 16 | The ge- nome sequence of Drosophila melanogaster 显示文摘 | ADAMS M D CELNIKER S E HOLT R A | 2000 | Sci- ence2000，287，5461： | 1 |
| 17 | Control of protein splicing by intein fragment reassembly显示文摘 | SOUTHWORTH M W ADAM E PANNE D | | 0，，04： | 1 |
| 18 | ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST- Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines( Writing Committee to Revise the 2002 Guidelines for the Manage- ment of Patients With Unstable Angina/Non - ST - Elevation Myocardi- al Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the A- merican Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine显示文摘 | Anderson J L Adams C D Amman E M | 2007 | J Am Coil Cardiol2007，50，7： | 1 |
| 19 | The role of CD4^+T-cell subsets in determining transplantation rejection or tolerance显示文摘 | Zelenika D Adams E Humm S | 2001 | Immunol Rev2001，182，8： | 1 |
| 20 | ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction:a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non- ST -Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians,the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine 显示文摘 | Anderson J L Adams C D Antman E M | 2007 | J Am Coil Cardiol2007，50，7： | 1 |
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