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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | 应用组织型纤溶酶原激活物行静脉溶栓治疗急性缺血性卒中的时间窗延长——美国心脏协会/美国卒中协会的科学建议显示文摘美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南,其中包括应用重组组织型纤溶酶原激活物(rt—PA)行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效,但由于患者通常在发病3h后方能到达医院,往往已经超过了用药的时间窗。因此,大部分缺血性卒中患者未能接受rt—PA治疗。目前研究认为,增加rt—PA治疗例数的最可能方法就是延长治疗时间窗。 | del Zoppo G J Saver J L Jauch E C Adams H P Jr. | 2009 | 中国脑血管病杂志2009，6，8： | 8 |
| 3 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 4 | Principal component analysis of dissolution data with missing elements显示文摘 | Adams E Walczak B Vervaet C Risha P G Massart D L | 1997 | Chemometrics and intelligent aboratory systems1997，，32： | 2 |
| 5 | Friedel - Crafts reactions in room temperature ionic liquids 显示文摘 | Adams C J Earle M J Roberts G | 1998 | Chem Commun1998，，19： | 1 |
| 6 | Short - channel effects and drain - induced barrier lowering in nanometerscale GaAs MESFET's 显示文摘 | James A Adams Thayne I G Wilkinson C D W | 1993 | IEEE Trans Electron Devices1993，40，6： | 1 |
| 7 | Discrete particle simulation ofagglomerate impact coalescence 显示文摘 | Lian G Thomtont C Adams M J | 1998 | Chemical Engineering Science(S0009-2509)1998，53，19： | 1 |
| 8 | Effect of fibre orientation and laminate geometry on the dynamic properties of CFRP显示文摘 | Adams R D Bacon D G C | 1973 | Journal of composite naaterials1973，7，4： | 1 |
| 9 | Cerebral sinovenous thrombosis in children显示文摘 | Deveber G Andrew M Adams C | 2001 | N Engl J Med2001，345，6： | 1 |
| 10 | Transposon derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival显示文摘 | Allen C A Adams L G Ficht T A | 1998 | Infect Immun1998，66，： | 1 |
| 11 | Measurement of the flexural damping capacity and dynamic Yotmg's modulus of metals and reinforced plastics 显示文摘 | Adams R D Bacon D G C | 1973 | Journal of physics D: applied physics1973，6，1： | 1 |
| 12 | Mechanism of bacterial cell-surface attachment revealed by the structure of cellulosomal type 11 cohesin-dockerin complex 显示文摘 | Adams J J Pal G Jia Z C | 2006 | Proc Natl Acad Sci2006，103，： | 1 |
| 13 | Pseudobulb injected growth regulators as aids for year around production of Hawaiian Dendrobium orchid cut flowers 显示文摘 | SAKAI W S ADAMS C BRAUN G | 2000 | Acta Horticuhurae2000，514，2： | 1 |
| 14 | The effects of Fenton's reagent pretreatment on the biodegradability of nonionic surfactants 显示文摘 | Kitis M Adams C D Daigger G T | 1999 | Water Research1999，33，11： | 1 |
| 15 | Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes 显示文摘 | Riechmann J L Heard J Martin G Reuber L Jiang C Keddie J Adam L Pineda O Ratcliffe O J Samaha R R Creelman R Pilgrim M Broun P Zhang J Z Ghandehari D Sherman B K Yu G | 2000 | Science2000，290，： | 1 |
| 16 | Arabidopsis transcription factors:genome-wide comparative analysis among eukaryotes显示文摘 | RIECHMANN J L HEARD J MARTIN G REUBER L JIANG C KEDDIE J ADAM L PINEDA O RATCLIFFE O J SAMAHA R R | 2000 | Science2000，290，： | 1 |
| 17 | Alkylphenol ethoxylates in the environment显示文摘 | Naylor C G Mieure J P Adams W J Weeks J A Castaldl F J Ogle L D Romano R R | 1992 | American Oil Chemists Society1992，69，： | 1 |
| 18 | Effect of fiber-orientation and laminate geometry on properties of CFRP显示文摘 | Adams R D Bacon D G C | 1973 | Journal of Composite Material1973，7，： | 1 |
| 19 | Alkylphenol ethoxylates in the environment显示文摘 | NAYLOR C G MIEURE J P ADAMS W J | 1992 | Am Oil Chem Soc1992，69，7： | 1 |
| 20 | Effect of fiber orientation and laminate geometry on the dynamic properties of CFRP显示文摘 | Adams R D Bacon D G C | 1973 | J Comp Mater1973，7，： | 1 |
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