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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 3 | A novel tunnd structure containing enclathrated hydrogen peroxide:4Na2SO4 · 2H2O2· NaCl显示文摘 | ADAMS JOHN M PRITCHARD ROBIN G THOMAS JOHN M | 1978 | Journal of Chemical Society Chem Conm1978，，3： | 1 |
| 4 | Friedel - Crafts reactions in room temperature ionic liquids 显示文摘 | Adams C J Earle M J Roberts G | 1998 | Chem Commun1998，，19： | 1 |
| 5 | Inhibition of avian leukosis virus replication by vector-based RNA interference显示文摘 | Chen M Adam J G Matthew W | 2007 | Virology2007，365，： | 1 |
| 6 | Guidelines for the early management of adults with ischemic stroke : a guideline from the American Heart Association/American Stroke Association Stroke Coun- cil, Clinical Cardiology Council, Cardiovascular Radiology and Inter- vention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists 显示文摘 | Adams H P Jr del-Zoppo G Alberts M J | 2007 | Stroke2007，38，5： | 1 |
| 7 | Discrete particle simulation ofagglomerate impact coalescence 显示文摘 | Lian G Thomtont C Adams M J | 1998 | Chemical Engineering Science(S0009-2509)1998，53，19： | 1 |
| 8 | Monoclonal antibody therapy of cancer显示文摘 | Adams G P Weiner L M | 2005 | Nat Biotechnol2005，23，9： | 1 |
| 9 | Guidelines for the early management of adults withischemic stroke: a guideline from the American Heart Association/American Stroke Association StrokeCouncil, ClinicalCardiology Council, CardiovascularRadiology and Inter vent ion Council, and theAtherosclerotic Peripheral VascularDisease andQualityof CareOutcomeinResearchlnterdisciplinary Working Groups:the American Academy of Neurologyaffirms the value of this guideline as an educationaltool for neurologists 显示文摘 | ADAMS H P JR DEL ZOPPO G ALBER TS M J | 2007 | Stroke2007，38，： | 1 |
| 10 | Cerebral sinovenous thrombosis in children显示文摘 | Deveber G Andrew M Adams C | 2001 | N Engl J Med2001，345，6： | 1 |
| 11 | Tne crystal structure of 4Na2SO4·2H2O2·NaCl显示文摘 | ADAMS J M PRITCHARD R G | 1978 | Acta Cryst1978，34，5： | 1 |
| 12 | The Effects and Limitations of Automated Text Condensing on Reading Comprehension Performance显示文摘 | Morris A H Kaspcr G M Adams D A | 1992 | Information Systems Research1992，，1： | 1 |
| 13 | Phenytoin reduces the contraction of recessive dystrophic epidermolysis bullosa fibroblast populated collagen gels显示文摘 | Talas G Adams TS Eastwood M | 1997 | Int J Biochem Cell Biol1997，29，1： | 1 |
| 14 | Qualitative assessment of hospitalized patient s'satisfaction with pain management显示文摘 | Sherwood G Adams M J Starck PL | 2000 | Res Nurs Health2000，23，48： | 1 |
| 15 | Plasma characterization and room temperature growth of carbon nanotubes and nano-onions by excimer laser ablation 显示文摘 | RADHAKRISHNAN G ADAMS P M BERNSTEIN L S | 2007 | Applied Surface Science2007，253，19： | 1 |
| 16 | Contact modeling-forces 显示文摘 | Adams G G Nosonovsky M | 2000 | Tribology Int2000，33，43： | 1 |
| 17 | The nondirected live-kindey donor:ethical considerations and practice guideline:a national conference report显示文摘 | ADAMS P L COHEN D J DANOVITCH G M | 2002 | Transplantation2002，74，4： | 1 |
| 18 | Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block-poly(N-hexyl-l-aspartamide)-acyl conjugate micelles:effects of acyl chain length显示文摘 | ADAMS M L KWON G S | 2003 | Journal of controlled release2003，87，1： | 1 |
| 19 | The effects of Fenton's reagent pretreatment on the biodegradability of nonionic surfactants 显示文摘 | Kitis M Adams C D Daigger G T | 1999 | Water Research1999，33，11： | 1 |
| 20 | Microstrueture of dense thin sheets of γ-TiAl fabricated by hot isostatic pressing of tape-cast monotapes 显示文摘 | ADAMS A G RAHAMAN M N DUTTON R E | 2008 | Materials Science and Engineering2008，447，： | 1 |
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