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| 1 | Cardiovascular and metabolic effects of Berberine显示文摘Berberine(BBR) is a natural alkaloid isolated from the Coptis Chinensis.While this plant has been used in Ay-urvedic and Chinese medicine for more than 2500 years,interest in its effects in metabolic and cardiovascular disease has been growing in the Western world in the last decade.Many papers have been published in these years reporting beneficial effects in carbohydrate and lip-id metabolism,endothelial function and the cardiovascu-lar system.In this review,we report a detailed analysis of the scientific literature regarding this topic,describing the effects and the underlying mechanisms of BBR on carbohydrate and lipid metabolism,endothelial function and the cardiovascular system. | Flora Affuso Valentina Mercurio Valeria Fazio Serafino Fazio | 2010 | World Journal of Cardiology2010，2，4： | 10 |
| 2 | A nutraceutical combination improves insulin sensitivity in patients with metabolic syndrome显示文摘AIM:To test the efficacy of a proprietary nutraceutical combination in reducing insulin resistance associated with the metabolic syndrome(MetS).METHODS:Sixty-four patients with MetS followed at a tertiary outpatient clinic were randomly assigned to receive either placebo or a proprietary nutraceutical combination(AP)consisting of berberine,policosanol and red yeast rice,in a prospective,double-blind,placebo-controlled study.Evaluations were performed at baseline and after 18 wk of treatment.The homeostasis model assessment of insulin resistance(HOMAIR)index was the primary outcome measure.Secondary endpoints included lipid panel,blood glucose and insulin fasting,after a standard mixed meal and after an oral glucose tolerance test(OGTT),ow-mediated dilation(FMD),and waist circumference.RESULTS:Fifty nine patients completed the study,2 withdrew because of adverse effects.After 18 wk there was a signif icant reduction in the HOMA-IR index in the AP group compared with placebo(ΔHOMA respectively-0.6 ± 1.2 vs 0.4 ± 1.9;P < 0.05).Total and low density lipoprotein cholesterol also significantly decreased in the treatment arm compared with placebo(Δlow density lipoprotein cholesterol-0.82 ± 0.68 vs-0.13 ± 0.55 mmol/L;P < 0.001),while triglycerides,high density lipoprotein cholesterol,and the OGTT were not affected.In addition,there were significant reductions in blood glucose and insulin after the standard mixed meal,as well as an increase in FMD(ΔFMD 1.9 ± 4.2 vs 0 ± 1.9 %;P < 0.05)and a significant reduction in arterial systolic blood pressure in the AP arm.CONCLUSION:This short-term study shows that AP has relevant beneficial effects on insulin resistance and many other components of MetS. | Flora Affuso Valentina Mercurio Antonio Ruvolo Concetta Pirozzi Filomena Micillo Guido Carlomagno Fabrizia Grieco Serafino Fazio | 2012 | World Journal of Cardiology2012，4，3： | 7 |
| 3 | Efficacy and safety of valsartan plus hydroclorothiazide for high blood pressure显示文摘AIM:To evaluate efficacy and tolerability of the combination valsartan plus hydrochlorothiazide(160 mg and 25 mg daily,respectively) in young-middle aged males with high-normal blood pressure(BP) or firstdegree arterial hypertension with evidence of target organ damage.METHODS:Twenty males with high-normal BP or first-degree hypertension associated with left ventricular concentric remodeling and/or increased aortic stiffness were enrolled.BP at rest and during exercise,and echocardiographic parameters of the left ventricle(LV),were evaluated at baseline and after 3 mo of treatment.The effects of treatment on aortic stiffness,metabolic parameters,renal and erectile function were also assessed.RESULTS:BP was significantly reduced by treatment both at rest(P < 0.001) and during exercise(P < 0.001),and 85% of patients achieved BP normalization(< 130/85 mmHg).Doppler echocardiography showed a significant reduction of LV mass(P < 0.005).LV hypertrophy was identified in 70% of subjects at baseline and in 5% after 3 mo of treatment.The ratio of early(E) to late(A) trans-mitral diastolic flow velocity increased,(P < 0.05),the relative wall thickness decreased(P < 0.05) and the left ventricular relaxation time shortened(P < 0.005).The left atrial diameter(P < 0.05) and the aortic diameter(P < 0.05) and stiffness(P < 0.005) also decreased.CONCLUSION:The full-dose combination of valsartan plus hydrochlorothiazide produced optimal BP control with regression of target organ damage,already after 3 mo,without relevant side effects. | Antonio Ruvolo Valentina Mercurio Valeria Fazio Guido Carlomagno Teresa Russo Flora Affuso Serafino Fazio | 2010 | World Journal of Cardiology2010，2，5： | 4 |
| 4 | Myocarditis and dilated eardiomyopathy : possible connections and treatments显示文摘 | CASTELLANO G AFFUSO F DI C P | 2008 | J Cardiovasc Med2008，9，7： | 1 |
| 5 | Myocarditis and dilated cardiomyopathy:possible connections and treatments显示文摘 | CASTELLANO G AFFUSO F DI CONZA P | 2008 | J Cardiovasc Med2008，9，： | 1 |
| 6 | Myocarditis and dilated cardiomyopathy:possible connections and treatments显示文摘 | CASTELLANO G AFFUSO F DI CONZA P | 2008 | J Cardiovasc Med(Hagerstown)2008，9，： | 1 |
| 7 | Myocarditis and dilated cardiomyopathy: possible connections and treatments 显示文摘 | Castellano G Affuso F Di Conza P | 2008 | J Cardiovasc Med2008，9，7： | 1 |
| 8 | Vascular smooth muscle cell dysfunction in patients with migraine显示文摘 | R Napoli V Guardasole E Zarra M Matarazzo C D?Anna F Saccà F Affuso A Cittadini P B. Carrieri L Saccà | 2009 | Neurology2009，，24： | 1 |
| 9 | Nonoperative management of isolated cefiac and superiormesenteric artery dissection: case report and review of the literature显示文摘 | Mousa AY Coyle BW Affuso J | 2009 | Vascular2009，17，6： | 1 |
| 10 | Long term combination treatment for severe idiopathic pulmonary arterial hypertension显示文摘We report the long-term follow-up of 3 cases of severe idiopathic pulmonary arterial hypertension,in whom tadalafil plus sitaxentan combination therapy improved the clinical condition and exercise performance without any relevant adverse event. | Flora Affuso Plinio Cirillo Antonio Ruvolo Guido Carlomagno Serafino Fazio | 2010 | World Journal of Cardiology2010，2，3： | 1 |
| 11 | A model for sustainable land use in biofuel production:An application to the state of Alaba- ma显示文摘 | Affuso E Hite D | 2013 | Energy Economics2013，37，： | 1 |
| 12 | Myocarditis and dilated cardiomyopathy: possible connections and treatments 显示文摘 | Castellano G Affuso F Di Conza P | 2008 | J Cardiovasc Med (Hagerstown)2008，9，7： | 1 |
| 13 | Myocarditis and dilated cardiomyopathy: possible connections and treatments 显示文摘 | Castellano G Affuso F Di Conza P | 2008 | J Cardiovasc Med(Hagerstown)2008，9，7： | 1 |
| 14 | Nonoperative management of isolated celiac and superior mesenterie artery dissection: case report and review of the literature显示文摘 | Mousa AY Coyle BW Affuso J | 2009 | Vascular2009，17，6： | 1 |
| 15 | Myocarditis and dilated cardiomyopathy: possible connections and treatments显示文摘 | CASTELLANO G AFFUSO F DI CONZA P | 2008 | J Cardiovase Med2008，9，7： | 1 |
| 16 | Nonoperative managementof isolated celiac and superior mesenteric artery dissection: casereport and review of the literature显示文摘 | Mousa AY Coyle BW Affuso J | 2009 | Vascular2009，17，6： | 1 |
| 17 | Nonoperative management of isolated celiac and superior mesenteric artery dissection : case report and review of the literature显示文摘 | Mousa A Y Coyle B W Affuso J | 2009 | Vascular2009，17，6： | 1 |
| 18 | Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function: a randomized, double-blind, pla- cebo-controlled study 显示文摘 | Affuso F Ruvalo A Micillo F | 2010 | Nutr Metab Cardiovasc Dis2010，20，9： | 1 |
| 19 | Application of optical flow method to inspiratory and expiratory lung MDCT to assess regional air trapping: a feasibilitiy study 显示文摘 | Torigian DA Gefter WB Affuso JD | 2007 | AJR Am J Roentgenol2007，188，3： | 1 |
| 20 | Nonoperative manage- ment of isolated celiac and superior mesenteric artery dis- section:case report and review of the literature 显示文摘 | Mousa AY Coyle BW Affuso J | 2009 | Vascu- lar2009，17，6： | 1 |
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