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| 1 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 2 | A comparison of five rapid direct toxicity assessment methods to determine toxicity of pollutant s to active sludge显示文摘 | Dalzell D J B Ahes Aspichueta E | 2002 | Chemosphere2002，47，： | 1 |
| 3 | Effect of fermentation on the in vitro protein digestibility of pearl millet显示文摘 | Ali MAM Tinay A H E Abdalla AH | 2003 | Food Chemistry2003，80，1： | 1 |
| 4 | The function of programmed cell death I and its ligands in regulating autoimmunity and infection显示文摘 | Sharpe AH Wherry E J Ahmed R | 2007 | Nat Immunol2007，8，3： | 1 |
| 5 | Mosaieism of autosomes and sex chromosomesin morphologieally normal,monospermic Preimplantation humanembryos显示文摘 | Harper JC Coonen E Handyside AH | 1995 | Prenat Diagn1995，15，1： | 1 |
| 6 | coli using anodic stripping vohammetry based on Cu@Au nanoparticles as antibody labels显示文摘 | Zhang XN Geng P Liu H J et ah Development of an electrochemical immunoassay for rapid detection of E | 2009 | Biosensors and Bioelectron- ics2009，24，7： | 1 |
| 7 | Reducing ate- lectasis attenuates bacterial growth and translocation in experi- mental pneumonia显示文摘 | van Kaam AH Lachmann RA Herring E | 2004 | Am J Respir Crit Care Med2004，16，9： | 1 |
| 8 | Evaluation of the use of monoclonal antibodies and nested PCR for noninvasive prenatal diagnosis of hemoglobinopathies in India显示文摘 | D′Souza E Sawant PM Nadkarni AH | 2008 | Am J Clin Pathol2008，130，86： | 1 |
| 9 | Ventilator-associated pneumonia:issues reIated to the artificial airway显示文摘 | Diaz E Rodrigue AH Rello J | 2005 | Respir Care2005，50，7： | 1 |
| 10 | Quantification of cardiac function with multislice spiral CT using retrospective EKG-gating:comparison with MRI显示文摘 | Mahnken AH Sptintrup E Wildberger JE | 2003 | Rofo2003，175，1： | 1 |
| 11 | Bone ingrowth in bFGF- coated hydroxyapatite ceramic implants 显示文摘 | Schneltler R Ah V Dingcldein E | 2003 | Biomalerials2003，24，25： | 1 |
| 12 | eft atrial appendage closure with the Amplatzer car- diac plug in patients with atrial fibrillation显示文摘 | GUERIOS E E SCHMID M GLOEKLER S et ah l | | Arq Bras Cardiol0，98，： | 1 |
| 13 | Real - Worht Data on SSRI Antidepressant Side Effects 显示文摘 | Cascade E AH Kalali SH Kennedy | 2009 | Psychiatry ( Edgmont )2009，6，2： | 1 |
| 14 | Paravascular cells in endosteal spaces of alveolar bone contribute to periodontal ligament cell populations显示文摘 | McCulloch CA Nemeth E Lowenberg B Melcher AH | 1987 | Anat Rec1987，219，3： | 1 |
| 15 | Bronchopulmonary dysplasia显示文摘 | Jobe AH Bancalari E | 2001 | Am J Respir Crit Care Med2001，163，7： | 1 |
| 16 | Methylenetetrahydrofolate reductase gene polymorphisms : genomic predictors of clinical response to fluoropyrimidine-based chemotherapy?显示文摘 | Marcuello E Ahes A Menoyo A | 2006 | Cancer Chemother Pharmacol2006，57，6： | 1 |
| 17 | Postoperative astigmatism and rotational stability after Artisan toric phakic intraocular lens implantation显示文摘 | Tehrani M Dick I-IB Schwenn O Blom E Schmidt AH | 2003 | J Cataract Refract Surg2003，29，9： | 1 |
| 18 | Numerical changes in the various peripheral white blood cells in children as a result of antineoplastic therapy 显示文摘 | Cranendonk E Van Gennip AH Abeling NG | 1984 | Acta Haematol1984，72，5： | 1 |
| 19 | Ventilator-associated pneumonia:Issues related to the artificial airway显示文摘 | Diaz E Rodrguez AH Rello J | 2005 | Respir Care2005，50，： | 1 |
| 20 | P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs显示文摘 | SCHINKEL AH WAGENAAR E MOL CA | 1996 | J Clin Invest1996，97，11： | 1 |
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