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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 3 | 黄芪总黄酮对扑热息痛所致肝损伤的防护机理探讨显示文摘目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ,其变化与TFA浓度成反比 ;但对其它代谢产物的影响无明显统计学差异。苯巴比妥诱导小鼠睡眠实验结果显示 ,TFA (10 0mg·kg-1)本身对苯巴比妥代谢无明显影响 (P >0 .0 5 ) ,扑热息痛 (40 0mg·kg-1)可显著延长小鼠的睡眠时间 (P <0 .0 0 1) ;但TFA (10 0mg·kg-1)明显缩短扑热息痛所延长的苯巴比妥诱导的睡眠时间 (P <0 .0 0 5 )。结论 | 汪德清 Critchley Julian AJH 丁保国 马艳青 赵海潞 Thomas G Neil 田亚平 Tomlinson B rian Critchley Lester AH James Anthony Edward | 2001 | 中国中药杂志2001，26，9： | 13 |
| 4 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 5 | Mitogenicity of the recombinant myco- bacterial 27-kilodalton lipoprotein is not connected to its anti- protective effect 显示文摘 | Hovav AH Davidoviteh L Nussbaum G Mullerad J Fish- man Y Bercovier H | 2004 | Infect Immun2004，72，6： | 1 |
| 6 | The third helix of the Antennapedia homeodomain translocates through biological membranes显示文摘 | Derossi D Joliot AH Chassaing G | 1994 | J Biol Chem1994，269，10： | 1 |
| 7 | Cardiac amyloidoma with IgM-κ gammopathy显示文摘 | Kathleen JW Gerald G Guillermo AH | 1994 | Arch Pathol Lab Med1994，118，： | 1 |
| 8 | AN evaluation of salmeterol in the treatment of chronic obstructive pulmonary disease (COPD)显示文摘 | Boyd G Moric AH Pounsford JC | 1997 | Eur Respir J1997，10，4： | 1 |
| 9 | Community structure of denitrifiers, bacteria, and archaea along redox gradients in Pacific Northwest marine sediments by terminal restriction fragment length polymorphism analysis of amplified nitrite reductase (nitS) and 16S rRNA genes显示文摘 | Braker G Ayala-del-Rio HL Devol AH | 2001 | Applied and Environmental Microbiology2001，67，4： | 1 |
| 10 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 11 | Promotion of wellswitching to mitigate the current arsenic crisis in bangladesh 显示文摘 | VAN G A AHSAN H HOMEMAN AH | 2002 | Bull World Health Organ2002，80，9： | 1 |
| 12 | Chronic inflammatory demyelinating polyneuropathy: clinical features and response to treatment in 67 consecutive patients with and without monoclonal gammopathy显示文摘 | Gorson KC Allam G Ropper AH | 1997 | Neurology1997，48，2： | 1 |
| 13 | MR signal intensity characteristics in Legg-Calve-Perthes disease显示文摘 | Mahnken AH Staatz G Ihme N | 2002 | Acta Radiol2002，43，3： | 1 |
| 14 | Role of SKCa and IKCa in the endothelium-dependent hyperpolarization of the guinea-pig isolated carotid artery显示文摘 | Gluais P Edwards G Weston AH | 2005 | Br J Pharmacol2005，144，4： | 1 |
| 15 | Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models ofAlzheimer' s disease 显示文摘 | Nagahara AH Merrill DA Coppola G | 2009 | Nat Med2009，，： | 1 |
| 16 | Induction of a graft-versus-leukemia reaction by cyclosporine A withdrawal as immunotherapy for leukemia relapsing after allogeneic bone marrow transplant显示文摘 | Elmaagacli AH Beelen DW Trenn G | 1999 | Bone Marrow Transplant1999，23，8： | 1 |
| 17 | Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease显示文摘 | Nagahara AH Merrill DA Coppola G | 2009 | Nat Med2009，15，3： | 1 |
| 18 | Pharmacology of the potassium channel openers显示文摘 | Weston AH | 1995 | Cardiovasc Drugs Ther1995，9，： | 1 |
| 19 | Crack growth resistance of alumina, zircania and zircania toughened alumina ceramics for joint prostheses 显示文摘 | De Aza AH Cheralier J Fantozzi G | 2002 | Biomaterials2002，23，3： | 1 |
| 20 | Burden of bipolar depression: impact of disorder and medications on quality of life显示文摘 | Michalak EE Murray G Young AH | 2008 | CNS Drugs2008，22，5： | 1 |
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