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| 1 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 2 | Thioredoxin-interacting pro tein is stimulated by glucose through a carbohydrate response element and induces β-cell apoptosis显示文摘 | Minn AH Hafele C Shalev A | 2005 | Endocrinology2005，146，5： | 1 |
| 3 | Solvent extraction of the oils of rubber,melon, pumpkin and oilbean seeds 显示文摘 | ATI'AH J C IBEMESI J A | 1990 | J Am Oil Chem Soc1990，67，1： | 1 |
| 4 | The B-Lynch surgical technique for the control of massive postpartum haemorrhage:an alternative to hysterectong?Five case reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | Br J Obstet Gynaecol1997，104，3： | 1 |
| 5 | The B-Lynch surgical technique for the control of massive postpartum haemorrhage:analternative to hysterectomy?Five cases reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | Br J Obstet Gynaecol1997，104，3： | 1 |
| 6 | The B-Lynch surgical technique for the control of massive postpartum hemorrhage: an alternative to hysterectomy Five cases Reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | Br J Obstet Gynaecol1997，104，3： | 1 |
| 7 | Molecular distinction between alternative oxidase from monocots and dicots显示文摘 | Considine M J Holzapffe R C Day D A Whelan J Millar AH | 2002 | Plant Physiol2002，129，： | 1 |
| 8 | The B--Lynch surgical tech- nique for thecontrol ofmassive postpartum haemorrhage: all al-er- mative to hystectomy Five easesrepo-ed 显示文摘 | B-Lynch C Cokcr A Lawal AH | 1997 | Br J Obstet Gynecol1997，104，1： | 1 |
| 9 | The B-Lynch surgical technique for the control of massive postpartum hemorrhage :An alternative to hys- terectomy five cases reported显示文摘 | Lynch C Coker A Lawal AH | 1997 | Br J Obstet GynaecoI1997，104，3： | 1 |
| 10 | The B-Lynch sur- gical technique for the control of massive postpartum hemorrhage: an alternative to hysterectomy? Five cases reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | Br J Obstet Gynecol1997，104，3： | 1 |
| 11 | The B-Lynch surgical technique for the control of massive postpartum haemorrhage : an alternative to hysterectomy? Five cases reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | Br J Obstet Gynaecol1997，104，3： | 1 |
| 12 | The B-Lynch surgical technique for the control of massive postpartum haemorrhage:an alternative to hysterectomy?Five cases reported显示文摘 | C BL Coker A Lawal AH | 1997 | Br J Obstet Gynaecol1997，104，3： | 1 |
| 13 | The B-Lynch surgical technique for the control of massive postpartum hemorrhage: an alternative to hysterectomy Five cases Reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | Br J Obstel Gynaecol1997，104，3： | 1 |
| 14 | Patient-to-patientspread of a single strain of corynebacterium striatum causing in-fections in a surgical intensive care unit显示文摘 | Brandenburg AH Belkum A Pelt C | 1996 | Clin Microbiol1996，34，9： | 1 |
| 15 | plantations in the Horqin sandy land of Northeast China显示文摘 | Cao C Y Jiang D M Teng X H et ah Soil chemical and microbiological properties along a chronosequence o{ Caragana microphylla Lain | 2008 | Applied Soil Ecolo- gy2008，40，1： | 1 |
| 16 | B7 1PB7 eostimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low- density lipoprotein receptor- deficient mice显示文摘 | Buono C PangH Uchida Y Libby P Sharpe A Lichtman AH | 2004 | Circulation2004，109，16： | 1 |
| 17 | The B-lynch surgical technique for the control of massive postpartum haemorrhage:an alternative to hysterectomy five eases reported显示文摘 | B-Lynch C Coker A Lawal AH at al | 1997 | Br J Obstet Gynaecol1997，104，3： | 1 |
| 18 | The B-Lynch surgical technique for the control of massive postpartum hemorrhage:an alternative to hysterectomy? Five cases reported显示文摘 | B-Lynch C Coker A Lawal AH | | 0，，03： | 1 |
| 19 | A single intermediate is responsible for cyclization, hydrolysis, and baseexchange chemistries显示文摘 | Sauve A A Munshi C Lee H C et ah The reaction mechanism for CD38 | 1998 | Biochemistry1998，37，13： | 1 |
| 20 | The B-Lynch surgical teohnique for the control of massive postpartum haemorrhage: an alternative to hysterectomy? Five cases reported显示文摘 | B-Lynch C Coker A Lawal AH | 1997 | British Journal of Obstetrics and Gynaecology1997，104，： | 1 |
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