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| 1 | Apoptosis and DNA damage in human spermatozoa显示文摘DNA 损坏经常在 subfertile 男性的精子被遇到并且包括损害授精与不利临床的结果的一个范围被相关,破坏 preimplantation 胚胎的开发,流产的增加的率和在子孙的疾病的提高的风险。在人的精子的 DNA 破碎的病原学密切与氧化的底的外观被相关使内收并且损害精子形式的证据。我们假设那个氧化压力阻碍精子形式,与糟糕改变的染色质导致精子的产生。这些有缺点的房间有一个趋势默认到线粒体与活动性损失, caspase 激活, phosphatidylserine exteriorization 和免费激进的产生的激活联系的一条 apoptotic 小径。后者导致类脂化合物 peroxidation 和氧化 DNA 损坏,它然后导致 DNA 破碎和房间死亡。精子的物理体系结构阻止从获得存取到原子 DNA 并且导致它的破碎由于这 apoptotic 进程激活的任何核酸酶。是为这个原因在人的精子遇到的 DNA 损坏的一个多数似乎氧化。给氧化应力似乎在 DNA 损坏的病原学有的重要角色,应该为在这个条件的处理的抗氧化剂有一个重要角色。如果在精子的氧化 DNA 损坏正在提供全身的氧化应力的敏感读出,这些调查结果的含意能在我们试着作为一篇序言在精子最小化 DNA 损坏到帮助概念治疗的立即的目标以外拉长。 | R John Aitken Adam J Koppers | 2011 | Asian Journal of Andrology2011，13，1： | 46 |
| 2 | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition显示文摘在人的不孕病人的精子在场的最普通的损害之一是精子鸡蛋识别的自发的失败。尽管这个唯一的细胞的相互作用现在能被象 intracytoplasmic 精子注射(ICSI ) 那样的帮助繁殖策略乐意地绕过,最近的大规模流行病学的研究鼓励了这种技术的小心的使用并且为对为有缺点的精子鸡蛋识别负责的机制的进一步的研究加亮需要。这个领域里的以前的工作证实了为卵母细胞相互作用负责的精子领域在动态地在女繁殖的道在 epididymal 成熟和 capacitation 期间被修改以前在精子发生期间被形成。当为这些顺序的 maturational 事件的规定负责的因素无疑是复杂的时,新兴的研究识别了分子的女伴,加热吃惊蛋白质 A2 (HSPA2 ) ,,在人的精子的这些事件的一个关键管理者。HSPA2 是支持合拢,运输,和集会蛋白质建筑群的 70 kDa 热吃惊蛋白质家庭的一个充实睾丸的成员并且断然被相关与在 vitro 授精(IVF ) 成功。而且,从人的精子 proteome 减少了 HSPA2 的表示为跟随 IVF 和 ICSI 的积云矩阵疏开,精子鸡蛋识别和授精导致一个损害能力。在这评论,我们考虑在精子功能支持 HSPA2 的角色的证据并且探索它被在不肥沃的病人的精子弄空的潜在的机制。进管理精子的分子的机制的如此的信息提议小说卓见工作。 | Brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 3 | Cellular mechanisms regulating sperm-zona pellucida interaction显示文摘 | Andrew T Reid Kate Redgrove R John Aitken Brett Nixon | 2011 | Asian Journal of Andrology2011，13，1： | 6 |
| 4 | Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models显示文摘基因混乱技术长为男繁殖生物学的学习是有益的。因为包含的时间和费用,除了在专家实验室,然而,这种技术不是一个可行方法。基因混乱的 CRISPR/Cas9 系统的来临迎来了基因调查的一个新时代。现在,在很小的时间并且以很小的成本产生破坏基因的老鼠模型是可能的。这篇热点文章讨论这种技术的应用程序在一些能被用来揭示男繁殖机制的必要、非本质的基因部件的这个系统的未来使用学习男富饶和外表的遗传。 | Samantha AM Young R John Aitken Masahito Ikawa | 2015 | Asian Journal of Andrology2015，17，4： | 4 |
| 5 | Serum vitamin D content is associated with semen|parameters and serum testosterone levels in men显示文摘The present study aimed to evaluate the influence of serum vitamin D levels on semen quality and testosterone levels.This is a crosssectional study conducted at Androscience,Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory in Sao Paulo,Brazil,with 508 male patients,aged 18-60 years,from 2007 to 2017.Seminal parameters and serum sexual hormones were correlated with serum vitamin D concentrations in 260 men selected by strict selection criteria.Patients were divided into normozoospermic group(NZG,n=124)and a group with seminal abnormalities(SAG,n=136).Evaluation included complete physical examination,past medical history,habits and lifestyle factors,two complete seminal analysis with sperm functional tests,serum levels of 25-hydroxy-vitamin D_(3)(25(OH)VD_(3)),total and free testosterone,luteinizing hormone(LH),follicle-stimulating hormone(FSH),sex hormone-binding globulin(SHBG),total cholesterol,homeostatic model assessment of insulin resistance(HOMA-IR)index,and karyotype.The mean concentration of 25(OH)VD_(3)was significantly lower in the SAG(P<0.001)and positively correlated with all baseline seminal parameters and total testosterone levels.In addition,serum vitamin D_(3)concentration was found to be positively correlated with sperm concentration(β=2.103;P<0.001),total number of spermatozoa with progressive motility(β=2.069;P=0.003),total number of motile spermatozoa(β=2.571;P=0.015),and strict morphology(β=0.056;P=0.006),regardless of other variables.This is the first comparative study to address the issue of serum vitamin D_(3)content between normozoospermic patients and those with sperm abnormalities.It clearly demonstrates a direct and positive relationship between serum vitamin D level and overall semen quality,male reproductive potential,and testosterone levels. | Inari M Ciccone Elaine MF Costa Juliana R Pariz Thiago A Teixeira Joel R Drevet Parviz Gharagozloo Robert J Aitken Jorge Hallak | 2021 | Asian Journal of Andrology2021，23，1： | 2 |
| 6 | Evaluation of a speetrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function 显示文摘 | Gomez E Irvine D S Aitken R J | 1998 | Int J Androl1998，21，2： | 1 |
| 7 | Redox regulation of tyro- sine phosphorylation in human spermatozoa and its role in human spermatozoa and its role in human sperm function 显示文摘 | Aitken R J Paterson M Fisher H | 1995 | J Cell Sci1995，108，： | 1 |
| 8 | Analysis of the ability of three probes targetin g the outer acrosomal membrane or acrosomal contents to detect the acrosome reac tion in human spermatozoa显示文摘 | Brindle J P | 1993 | Hum Reprod1993，8，10： | 1 |
| 9 | A cDNA encoding farnesyl pyrophosphate synthase in white lupin 显示文摘 | Attucci S Aitken S M Ibrahim R K | 1995 | Plant Physiol1995，108，： | 1 |
| 10 | Mesorectal excision for rectal cancer显示文摘 | Aitken R J | 1996 | Br J Surg1996，83，2： | 1 |
| 11 | Generation of reactive oxygen species, lipid peroxidation and human sperm function 显示文摘 | Aitken R J Clarkson J S Fishel S | 1989 | Biol Re- prod1989，41，： | 1 |
| 12 | Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa显示文摘 | Aitken R J Gordon E Harkiss D | 1998 | Biol Reprod1998，59，5： | 1 |
| 13 | Chromosome abnormalities in human embryos after in vitro fertilization 显示文摘 | Angell RR Aitken R J Van Look PF | 1983 | Nature1983，303，： | 1 |
| 14 | Indicators of staffing and equi- ty in Papua New Guinea 显示文摘 | R - Lkolehmainen - Aitken Peter Shipp | 1990 | Health Policy and Planning1990，5，2： | 1 |
| 15 | Safe handling of nanotechnology 显示文摘 | Maynard A Aitken R J Butz T | 2006 | Nature2006，444，7117： | 1 |
| 16 | A comparative study of oxidative DNA damage in mammalian spermatozoa 显示文摘 | Bennetts L E Aitken R J | 2005 | Mol Reprod Dev2005，71，： | 1 |
| 17 | The effect of valence and ionic- strength on the measurement of pH buffer capacity显示文摘 | Aitken R L Moody P W | 1994 | Soil Research1994，32，5： | 1 |
| 18 | Adoption of a sedation sco-ring system and sedation guideline in an intensive care unit显示文摘 | Elliott R McKinley S Aitken L | 2006 | J Adv Nurs2006，54，2： | 1 |
| 19 | Swithing maternal dietary intake at the end of the first trimester has profound effects on placenta development and fetal growth in adolescent ewes carrying singleton fetuses显示文摘 | WALLACE J M BOURKE M D A AITKEN R P | 1999 | Biol Reprod1999，61，： | 1 |
| 20 | An essential role for a phospholipid transfer protein in yeast Golgi function显示文摘 | Bankaitis V A Aitken J R Cleves A E | | 0，，6293： | 1 |
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