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| 1 | Non-bismuth quadruple therapy for first-line Helicobacter pylori eradication:A randomized study in Japan显示文摘AIM:To find the way to improve the eradication rate of first-line therapy in Japanese patients.METHODS:We prospectively compared the effectiveness of 7-d quadruple therapy to standard 7 d triple therapy in Japanese patients infected with Helicobacter pylori(H.pylori).One hundred and nineteen patients were randomly assigned to receive 7-d non-bismuth quadruple therapy with lansoprazole,amoxicillin,clarithromycin and metronidazole(LACM7) or 7-d triple therapy with lansoprazole,amoxicillin and clarithromycin(LAC7).After three months,H.pylori status was analyzed by 13C-urea breath test.Incidence rates of adverse events were evaluated by use of questionnaires.RESULTS:By intention-to-treat(ITT) analysis,the eradication rate in the LACM7 group was 94.9%,which was significantly higher than the LAC7 group(68.3%,P < 0.001).Per protocol analysis also showed a significantly higher eradication rate in the LACM7 group(98.3%) than the LAC7 group(73.2%,P < 0.001).Nevertheless,the incidence of serious adverse events did not differ between the two groups(RR:1.10,95% CI:0.70-1.73,P = 0.67).CONCLUSION:Seven day non-bismuth quadruple therapy(LACM7) was superior to standard 7-d triple therapy(LAC7) for first-line eradication. | Ayako Yanai Kei Sakamoto Masao Akanuma Keiji Ogura Shin Maeda | 2012 | World Journal of Gastrointestinal Pharmacology and Therapeutics2012，3，1： | 5 |
| 2 | ApoE isoforms,treatment of diabetes and the risk of coronary heart disease显示文摘AIM:To analyze the risk of coronary heart disease in patients with type 2 diabetes mellitus(T2DM)receiving standard medical treatment.METHODS:We performed a retrospective chart analysis of 269 middle-aged patients(age 45-64 years,mean age,53.9±5.5 years)with T2DM and without atherosclerotic cardiovascular events who underwent typing to determine their apolipoprotein E(apoE)isoforms.The apoE isoforms were determined using isoelectric focusing,followed by immunoblotting.We retrospectively evaluated the charts of the 269 patients,recorded between their first visit to the hospital(the study's start point,between 1987 and 1992)and the occurrence of an atherosclerotic cardiovascular event(the study's endpoint)or January 2004,whichever came first.The age-adjusted mean values and the prevalences of covariates were calculated to compare the laboratory data among the apoE phenotypes.To investigate the association of risk factors with the incidence of coronary heart disease during the follow-up period,monovariate and multivariate Cox regression models were used.RESULTS:At enrollment,the mean serum low density lipoprotein(LDL)cholesterol levels were lowest(2.92± 0.89 mmol/L)among the subjects with apoE2(apoE2/2 or apoE2/3)and highest(3.52±0.77 mmol/L)among the subjects with apoE4(apoE3/4 or apoE4/4).No significant differences in mean age or the percentage of smokers were observed among the three groups.Furthermore,no significant differences were observed in the systolic and diastolic blood pressures,body mass index,HbA1c level or serum triglyceride levels among the three groups.There were 47 cases of coronary heart disease over 3285 person-years of follow-up.An age-adjusted multivariate Cox proportional model identified diabetic retinopathy(hazard ratio,2.38,95% CI:1.28-4.43,P=0.006),a high systolic blood pressure(hazard ratio,1.04,95%CI:1.02-1.06,P<0.001) and high HbA1c values(hazard ratio,1.19,95%CI:1.02-1.38,P=0.0029),but not the LDL cholesterol value at enrollment(hazard ratio,1.01,95%CI:0.97-1.05,P=0.77)nor the specific apoE isoform,as significant predictors of coronary heart disease.CONCLUSION:Under standard medical treatment of diabetes,including the control of LDL cholesterol levels,the apoE4 isoform was not associated with coronary heart disease among T2DM patients. | Hideki Ehara Ritsuko Yamamoto-Honda Hiroji Kitazato Yoshihiko Takahashi Shoji Kawazu Yasuo Akanuma Mitsuhiko Noda | 2012 | World Journal of Diabetes2012，3，3： | 3 |
| 3 | Glycogen storage diseasetype la: molecular diagnosis of 51 Japanese patients and character-ization of splicing mutations by analysis of ectopically transcribedmRNA from lymphoblastic cells 显示文摘 | Akanuma J Nishigaki T Fujii K | 2000 | Am J Med Genet2000，91，2： | 1 |
| 4 | Scanning tunneling microscopy study of interfacial structure of InAs quantum dots on InP(001 ) grown by a double-cap method显示文摘 | Akanuma Y Yamakawa I Sakuma Y | 2007 | Applied Physics Letters2007，90，9： | 1 |
| 5 | Reduction and recovery of plasma 1,5-anhydm-D-glucitol level in diabetes mellitus显示文摘 | Yamanouchi T Akanuma H Asano T | 1987 | Diabetes1987，36，： | 1 |
| 6 | Improved social interaction and increased anterior cingulate metabolism after group reminiscence with reality orientation approach for vascular dementia显示文摘 | AKANUMA K MEGURO K MEGURO M | 2011 | Psychiatry Res2011，192，3： | 1 |
| 7 | Hydrogen perox-ide stimulates tyrosine phosphorylation of the insulin re-ceptor and its tyrosine kinase activity in intact cells 显示文摘 | KOSHIOO AKANUMA Y KASUGA M | 1988 | Biochem J1988，250，1： | 1 |
| 8 | A randomized controlled trial of the group reminiscence approach in patients with vascular dementia显示文摘 | ITO T MEGURO K AKANUMA K | 2007 | Dement Geriatr Cogn Disord2007，24，1： | 1 |
| 9 | Recurrent delusional i- deas due to left caudate head infarction, without dementia显示文摘 | Meguro K Meguro M Akanuma K | 2012 | Psy- chogeriatrics2012，12，1： | 1 |
| 10 | Long-term comparison of oral hypoglycemic agents in diabetic retinopathy Gliclazide vs other sulfonylureas显示文摘 | Kosaka K Kanazawa | 1998 | Diabetes Res Clin Prat1998，5，： | 1 |
| 11 | Carbon dioxide decomposition into carbon with the rhodium- bearing magnetite activated by Hz-reduction显示文摘 | Akanuma K Nishizawa K Kodama T | 1993 | J Mater Sci1993，28，4： | 1 |
| 12 | Myositis ossificans progressiva with parathroid hyperplasia and polycystic ovary显示文摘 | ISHIKAWA S AKANUMA N | 1976 | Acta Pathol Jpn1976，26，： | 1 |
| 13 | Reduction of plasma 1,5-anhydro-D-gluctitol(1-de-oxyglucose)concentration in diabetic patients显示文摘 | Yamanouchi T Akanuma H Nakamura T | 1988 | Diabetologia1988，31，： | 1 |
| 14 | Mitochondrial DNA variants in a Japanese population of patients with Alzheimer's disease显示文摘 | Tanaka N Goto Y Akanuma J | 2010 | Mitochondrion2010，10，1： | 1 |
| 15 | Distinct mechanism of Helicobacter pylori-mediated NF-κB activation between gastric cancer cells and monocytic cells显示文摘 | Shin Maeda Masao Akanuma Yuzo Mitsuno | 2001 | J Biolo Chem2001，276，44： | 1 |
| 16 | Liberation of zinc-containing L31(RpmE) from ribosomes by its paralogous gene product, YtiA, in Bacillus subtilis显示文摘 | Akanuma G Nanamiya H Natori Y | 2006 | J Bacteriol2006，188，7： | 1 |
| 17 | Homozygous deletions on the short ann of chromosome 3 in human oral squamous cell carcinomas显示文摘 | UZAWA N AKANUMA D NEGISHI A | 2001 | Oral Oncol2001，37，4： | 1 |
| 18 | A fail-safe system for the ribosome under zinc-limiting conditions in Bacillus subtilis显示文摘 | Natori Y Nanamiya H Akanuma G | 2007 | Mol Microbiol2007，63，1： | 1 |
| 19 | MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCNI and MMP14, in esophageal cancer显示文摘 | Akanuma N Hoshino I Akutsu Y | 2014 | British journal of cancer2014，110，1： | 1 |
| 20 | A novel mtDNA Cl1777A mutation in Leigh syndrome 显示文摘 | Komaki H Akanuma J Iwata H | 2003 | Mitochondrion2003，2，4： | 1 |
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