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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Effects of the nitrification inhibitor nitrapyrin and tillage practices on yield-scaled nitrous oxide emission from a maize field in Iran显示文摘Nitrification inhibitors can effectively decrease nitrification rates and nitrous oxide(N_(2)O)emission while increasing crop yield under certain conditions.However,there is no information available on the effects of nitrification inhibitors and tillage practices on N_(2)O emissions from maize cropping in Iran.To study how tillage practices and nitrapyrin(a nitrification inhibitor)affect N_(2)O emission,a split factorial experiment using a completely randomized block design with three replications was carried out in Northeast Iran,which has a cold semiarid climate.Two main plots were created with conventional tillage and minimum tillage levels,and two nitrogen(N)fertilizer(urea)management systems(with and without nitrapyrin application)were created as subplots.Tillage level did not have any significant effect on soil ammonium(NH_(4)^(+))and nitrate(NO_(3)^(-))concentrations,cumulative amount and yield-scaled N_(2)O emission,and aboveground biomass of maize,whereas nitrapyrin application showed significant effect.Nitrapyrin application significantly reduced the cumulative amount of N_(2)O emission by 41%and 32%in conventional tillage and minimum tillage practices,respectively.A reduction in soil NO_(3)^(-)concentration by nitrapyrin was also observed.The average yield-scaled N_(2)O emission was 13.6 g N_(2)O-N kg^(-1)N uptake in both tillage systems without nitrapyrin application and was significantly reduced to 7.9 and 8.2 g N_(2)O-N kg^(-1)N uptake upon the application of nitrapyrin in minimum tillage and conventional tillage practices,respectively.Additionally,nitrapyrin application increased maize biomass yield by 4%and 13%in the minimum tillage and conventional tillage systems,respectively.Our results indicate that nitrapyrin has a potential role in reducing N_(2)O emission from agricultural systems where urea fertilizers are broadcasted,which is common in Iran due to the practice of traditional farming. | Azam BORZOUEI Ulo MANDER Alar TEEMUSK Alberto SANZ-COBENA Mohammad ZAMAN Dong-Gill KIM Christoph MÜLLER Ali Askary KELESTANIE Parvaneh SAYYAD AMIN Ebrahim MOGHISEH Khadim DAWAR Ana Gabriela PÉREZ-CASTILLO | 2021 | Pedosphere2021，31，2： | 4 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Effects of the nitrification inhibitor nitrapyrin and the plant growth regulator gibberellic acid on yield-scale nitrous oxide emission in maize fields under hot climatic conditions显示文摘Nitrification inhibitors are widely used in agriculture to mitigate nitrous oxide(N_(2)O)emission and increase crop yield.However,no concrete information on their mitigation of N_(2)O emission is available under soil and environmental conditions as in Pakistan.A field experiment was established using a silt clay loam soil from Peshawar,Pakistan,to study the effect of urea applied in combination with a nitrification inhibitor,nitrapyrin(2-chloro-6-tri-chloromethyl pyridine),and/or a plant growth regulator,gibberellic acid(GA_3),on N_(2)O emission and the nitrogen(N)uptake efficiency of maize.The experimental design was a randomized complete block with five treatments in four replicates:control with no N(CK),urea(200 kg N ha^(-1))alone,urea in combination with nitrapyrin(700 g ha^(-1)),urea in combination with GA_3(60 g ha^(-1)),and urea in combination with nitrapyrin and GA_3.The N_(2)O emission,yield,N response efficiency,and total N uptake were measured during the experimental period.The treatment with urea and nitrapyrin reduced total N_(2)O emission by 39%–43%and decreased yield-scaled N_(2)O emission by 47%–52%,relative to the treatment with urea alone.The maize plant biomass,grain yield,and total N uptake increased significantly by 23%,17%,and 15%,respectively,in the treatment with urea and nitrapyrin,relative to the treatment with urea alone,which was possibly due to N saving,lower N loss,and increased N uptake in the form of ammonium;they were further enhanced in the treatment with urea,nitrapyrin,and GA_3 by 27%,36%,and 25%,respectively,probably because of the stimulating effect of GA_3 on plant growth and development and the reduction in biotic and abiotic stresses.These results suggest that applying urea in combination with nitrapyrin and GA_3 has the potential to mitigate N_(2)O emission,improve N response efficiency,and increase maize yield. | Khadim DAWAR Kamil SARDAR Mohammad ZAMAN Christoph MÜLLER Alberto SANZ-COBENA Aamir KHAN Azam BORZOUEI Ana Gabriela PÉREZ-CASTILLO | 2021 | Pedosphere2021，31，2： | 2 |
| 5 | Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine显示文摘Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell types.However,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative medicine.All the soluble factors and vesicles secreted by MSCs are commonly known as secretome.MSCs secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in vivo.Moreover,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and storage.Importantly,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of possibilities.Altogether these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field. | Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo | 2020 | World Journal of Stem Cells2020，12，12： | 2 |
| 6 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 7 | Autologous stem cell transplantation for systemic lupus erythematosus显示文摘 | David J Jacob P Alberto M | 2004 | Lupus2004，13，3： | 1 |
| 8 | New Design Approach for Steel Fiber-reinforced Concrete Slabs-on-ground Based on Fracture Mechanics显示文摘 | Alberto M Giovanni A P | 2004 | ACI Structural Journal2004，101，3： | 1 |
| 9 | Upgrading heavy oil using slurry processes显示文摘 | ALBERTO D B NICOLETTA P MARIO M | 1995 | Chemtech1995，25，11： | 1 |
| 10 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes显示文摘 | ALBERTO D R FRANCESCO P D M | 2004 | Chemical Engineering Science2004，59，13： | 1 |
| 11 | Attention deficit hyper- activity disorder in children with epilepsy 显示文摘 | Pasquale P Romino M Alberto V | 2010 | Brain Dev2010，32，1： | 1 |
| 12 | Fiat:Open Innovation in a Downturn(1993-2003)显示文摘 | ALBERTO D M FEDERICO F ANDREA P | 2010 | California Management Review2010，52，3： | 1 |
| 13 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 14 | Prevention and control of cystic echinococcosis显示文摘 | Philip S Craig Donald P McManus Marshall W Lightowlers Jose A Chabalgoity Hector H Garcia Cesar M Gavidia Robert H Gilman Armando E Gonzalez Myriam Lorca Cesar Naquira Alberto Nieto Peter M Schantz | 2007 | The Lancet Infectious Diseases2007，，6： | 1 |
| 15 | Upgrading heavy oil using slurry processes 显示文摘 | ALBERTO D B NICOLETTA P MARIO M | 1995 | Chemtech1995，25，11： | 1 |
| 16 | Modified FBD Method in Active Power Filters to Minimize the Line Current Harmonics 显示文摘 | Vctor M M Alberto P | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 17 | Rheological properties of aerated cement pastes with fly ash, metaka- olin and sepiolite additions 显示文摘 | Javier P M Alberto S A Francisco H O | 2014 | Construction and Build- ing Materials2014，65，： | 1 |
| 18 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes 显示文摘 | ALBERTO D R FRANCESCO P D M | 2004 | Chemical En- gineering Science2004，59，3： | 1 |
| 19 | Speed changes in the vicinity of horizontal curves on two-lane rural roads 显示文摘 | Alberto M F Medine Tarko P Andrew | 2007 | Journal of Transportation Engineering2007，133，4： | 1 |
| 20 | New design approach for steel fiber-reinforced concrete slabs-on-ground based on fracture mechanics 显示文摘 | Alberto M Giovanni A P | 2004 | ACI Structural Journal2004，101，3： | 1 |
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