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| 1 | 纤维母细胞生长因子对复合皮肤移植成活和收缩的影响显示文摘我们曾报道应用同基因表层皮片(IE)和同种异基因真皮(AD)组成复合皮肤移植物(CSG)可一次完成全层皮肤缺损的永久性修复。但由于IE不能及时获得足够血运,IE常有部分坏死,CSG后期收缩仍较明显。在本研究中我们进一步用纤维母细胞生长因子(FGF)预先处理AD获得较好效果。经观察17周表明,FGF组皮片坏死率和坏死面积较对照组明显下降(P<0.05);FGF组CSG收缩较对照组明显减轻(P<0.001);皮片坏死面积与皮片最终面积呈负相关(r=-0.450,P<0.05)。实验预示,完全成活的CSG后期收缩较移植同等厚度的IE为轻。观察2年,AD未被排斥。 | 方承辉 Robb E C 于光曙 Alexander J W Warden G D | 1993 | 中华整形烧伤外科杂志1993，9，1： | 6 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature显示文摘AIM:To critically review and summarize the literature on nutritional and health outcomes of semi-elemental formulations on various nutritionally vulnerable patient populations who are unable to achieve adequate nutrition from standard oral diets.METHODS:We conducted a comprehensive literature search of Pubmed and Embase databases.We manually screened articles that examined nutritional and health outcomes(e.g.,growth,disease activity,gastrointestinal impairment,mortality,and economic impact)among various patient groups receiving semi-elemental diets.This review focused on full-text articles of randomized controlled clinical trials and other intervention studies,but pertinent abstracts and case studies were also included.Results pertaining primarily to tolerance,digestion,and absorption were summarized for each patient population in this systematic review.RESULTS:Results pertaining primarily to tolerance,digestion,and absorption were summarized for each patient population.The efficacy of semi-elemental whey hydrolyzed protein(WHP)diet have been reported in various nutritionally high risk patient populations including-Crohn’s disease,short bowel syndrome,acute and chronic pancreatitis,cerebral palsy,cystic fibrosis,cerebrovascular accidents,human immunodeficiency virus,critically ill,and geriatrics.Collectively,the evidence from the medical literature indicates that feeding with a semi-elemental diet performs as well or better than parenteral or amino acid based diets in terms of toler-ance,digestion,and nutrient assimilation measures across various disease conditions.CONCLUSION:Based on this comprehensive review of the literature,patient populations who have difficulty digesting or absorbing standard diets may be able to achieve improved health and nutritional outcomes through the use of semi-elemental WHP diets. | Dominik D Alexander Lauren C Bylsma Laura Elkayam Douglas L Nguyen | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 3 |
| 4 | 使用二甲双胍的禁忌证 证据显示应该修改二甲双胍的禁忌证显示文摘在英国前瞻性糖尿病研究(UNPOS)中,2型糖尿病患者被随机分入二甲双胍、磺酰脲类或胰岛素强化治疗组,3组患者取得了相似的血糖控制效果,微血管并发症终点事件显著降低。该项研究显示,肥胖患者使用二甲双胍治疗可以降低心血管事件的发生,二甲双胍治疗组的患者没有低血糖事件。 | G C Jones J P Macklin W D Alexander 李玉秀 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 5 | Transcription factor early growth response 1 activity up-regulates expression of tissue inhibitor of metalloproteinases 1 in human synovial fibroblasts显示文摘 | Aicher WK Alexander D Haas C | 2003 | Arthritis Rheum2003，48，2： | 1 |
| 6 | Relation between stillbirth and specific chlorination by-products in public water supplies显示文摘 | WILL D KING LINDA DODDS ALEXANDER C ALLEM | 2000 | Environmental Health Perspectives2000，108，9： | 1 |
| 7 | Distribution of P, K, Ca, Mg, B, Cu, Mn and Zn in peanut lines near maturity 显示文摘 | Hallock D L Martens D C Alexander M W | 1971 | Agronomy Journal1971，63，2： | 1 |
| 8 | Molecularly imprinted drug delivery systems显示文摘 | CUNLIFFE D KIRBY A ALEXANDER C | 2005 | Adv Drug Deli Rev2005，57，12： | 1 |
| 9 | Thickness dependence of dielectric loss in SrTiO3thin films显示文摘 | LI H C SI W D ALEXANDER D W | 1998 | Appl Phys Lett1998，73，4： | 1 |
| 10 | Sediment accumu lation in a modern epieontinental-shelf setting: the Yellow Sea 显示文摘 | Alexander C R DeMaster D J Nittrouer C A | 1991 | Marine Geology1991，98，1： | 1 |
| 11 | Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways显示文摘 | Larsen C P Elwood E T Alexander D Z | 1996 | Nature1996，381，6581： | 1 |
| 12 | Diffusion tensormagnetic resonance image regularization显示文摘 | Coulon O Alexander D C and Arridge S | 2004 | Medical ImageAnalysis2004，8，1： | 1 |
| 13 | Coordinate gene activity in response to agents that in- duce systemic acquired resistance显示文摘 | WARD E R UKNESS S J WILLIAMS S C DINCHER S S WIEDER- HOLD D L ALEXANDER D C AHL-GOY P METRAUX J P RYALS J A | 1991 | Plant Cell1991，3，10： | 1 |
| 14 | 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the Ameri- can College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American As- sociation for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiogra- phy and Interventions, and Society of Thoracic Surgeons 显示文摘 | Fihn S D Blankenship J C Alexander K P | 2015 | J Thorac C ardiovasc Surg2015，149，3： | 1 |
| 15 | Sediment ac cumulation in a modern epicontinental shelf setting: The Yellow Sea显示文摘 | Alexander C R DeMaster D J Nittrouer C A | 1991 | Marine Geology1991，98，1： | 1 |
| 16 | Preliminary evaluation of hemagglutination and hemagglutination inhibition tests for avian infectious bronchitis virus显示文摘 | ALEXANDER D J BRACEWELL C D GOUGH R E | 1976 | Avian Pathology1976，5，： | 1 |
| 17 | The elec- tro-deoxidation of dense titanium dioxide precursors in molten calcium chloride giving a new reaction pathway 显示文摘 | Alexander D T L Schwandt C Fray D J | 2011 | Electrochimica Acta2011，56，9： | 1 |
| 18 | Origin of water and mantle-crust interactions on Mars inferred from hydrogen isotopes and volatile element abundances of olivine-hosted melt inclusions of primitive shergottites 显示文摘 | USUI T ALEXANDER C M O D WANG J | 2012 | Earth and Planetary Science Letters2012，，： | 1 |
| 19 | Microstructural kinetics of phase transformations during electrochemical reduction of titanium dioxide in molten calcium chloride显示文摘 | ALEXANDER D T L SCHWANDT C FRAY D J | 2006 | Acta Materialia2006，54，11： | 1 |
| 20 | Alter helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to the therapeutic vaccination in humans显示文摘 | Livingston B D Alexander J Crimi C | 1999 | Immunol1999，162，5： | 1 |
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