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| 1 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 2 | Relationship between organic matter content of soil and the sequestration of phenanthrene显示文摘 | Nam K Chung N Alexander M | 1998 | Environ Sci Technol1998，32，23： | 1 |
| 3 | 显示文摘 | Marina N Rumyantseva Alexander M | 2005 | Chemical Materials2005，17，： | 1 |
| 4 | Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development显示文摘 | Hansen L A Alexander N Hogan M E Sundberg J P Dlugosz A Threadgill D W Magnuson T Yuspa S H | | 0，，06： | 1 |
| 5 | Stability of thermocapillary flows with inclined temperature gradient 显示文摘 | ALEXANDER A N ILYAB S LEONID M B | 2001 | Journal of Fluid Mech2001，442，1： | 1 |
| 6 | Chimerism and tolerance in a recipient of a deceased-donor liver transplant显示文摘 | ALEXANDER S I SMITH N HU M | 2008 | N Engl J Med2008，358，4： | 1 |
| 7 | Relationship between organic matter content of soil and the sequestration of phenanthrene显示文摘 | Nam K Chung N Alexander M | 1998 | Environmental Science & Technology1998，32，23： | 1 |
| 8 | Inversion control in sugarcane juice with sodium Metasilieate显示文摘 | Alexander G B Acin N D Zapata R M | 1971 | Proc Int Soc Sugarcane Technol1971，13，： | 1 |
| 9 | Estimating the rational expectations model of speculative storage:A Monte Carlo comparison of three simulation estimators显示文摘 | Alexander M Serena N | 2000 | Journal of Econometrics2000，96，2： | 1 |
| 10 | Vector Fidelity of Land Multicomponent Measurements in the Context of the Earth-Sensor System:Misconceptions and Implications显示文摘 | Donald N B Alexander S C John M N GX Technology | 2005 | SEG/Houston 2005 Annual Meeting2005，，： | 1 |
| 11 | Winners and Losers in Housing Markets 显示文摘 | NOBUHIRO K ALEXANDER M KALIN N | 2011 | Journal of Money Credit andBanking2011，43，23： | 1 |
| 12 | Guidelines for the prevention of intravascular catheter-related infections 显示文摘 | O' Grady N P Alexander M Dellinger E P | 2002 | MMWR Reeomm Rep2002，51，10： | 1 |
| 13 | 显示文摘 | Gururaj M Valery N Alexander A Kateryna Y | 2010 | Poly- mer2010，51，： | 1 |
| 14 | Characterization of Cerevral Hemodynamic Phase Following Severe Head Trauma:Hypoperfusion,Hyperemia,and Vasospasm显示文摘 | Martin N A Patwardhan R V Alexander M | 1997 | J lbursurg1997，87，： | 1 |
| 15 | Cobalt-aluminum co-precipitated catalysts and their performance in the Fischer-Tropsch synthesis显示文摘 | ALEXANDER A Khassin TAMARA M Yurieva GALINA N Kustova | 2001 | Journal of Molecular Catalysis A: Chemical2001，168，： | 1 |
| 16 | Diabetes mellitus and odontogenic infections-ran exaggerated risk? 显示文摘 | Alexander M Krishnan B Shenoy N | 2008 | Oral Maxillofac Surg2008，12，： | 1 |
| 17 | 查看详情显示文摘 | Alexander C Andersson H S Andersson L I Ansell R J Kirsch N Nicholls I A O'Mahony J Whitcombe M J | | 0，，： | 1 |
| 18 | Cell typespecific transactivation of the VCAM-1 promoter through an NF-kappa B enhancer motif显示文摘 | Marui N Alexander RW | 1995 | J Biol Chem1995，270，15： | 1 |
| 19 | Usage of smart antenna for cancelling neighboring base-station interferences in wireless CDMA communicaions显示文摘 | YE W C BAR N ALEXANDER M H | 1997 | IEEE Signals Systems & Computers1997，1998，1： | 1 |
| 20 | Molecular imprinting science and technology:a survey of the literature for the years up to and including 2003显示文摘 | ALEXANDER C ANDERSSON H S ANDERSSON L I ANSELL R J KIRSCH N NICHOLLS I A OMAHONY J WHITCOMBE M J | 2006 | J Mol Recognit2006，19，2： | 1 |
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