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| 1 | Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over显示文摘AIM To increase the number of available grafts.METHODS This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation(LT) were performed with donors ≥ 70 years old(study group). Then, we selected the first cases that were performed with donors < 70 years old immediately after the ones that were performed with donors ≥ 70 years old(control group).RESULTS Graft and patient survivals were similar between both groups without increasing the risk of complications, especially primary non-function, vascular complications and biliary complications. We identified 5 risk factors as independent predictors of graft survival: recipient hepatitis C virus(HCV)-positivity [hazard ratio(HR) = 2.35; 95% confidence interval(CI): 1.55-3.56; P = 0.00]; recipient age(HR = 1.04; 95%CI: 1.02-1.06; P = 0.00); donor age X model for end-stage liver disease(D-MELD)(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); donor value of serum glutamic-pyruvic transaminase(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); and donor value of serum sodium(HR = 0.96; 95%CI: 0.94-0.99; P = 0.00). After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD(donor age X recipient age X MELD). Graft survival significantly decreased in patients with a DR-MELD score ≥ 75000, especially in HCV patients(77% vs 63% at 5 years in HCV-negative patients, P = 0.00; and 61% vs 25% at 5 years in HCV-positive patients; P = 0.00). CONCLUSION A DR-MELD ≥ 75000 must be avoided in order to obtain the best results in LT with donors ≥ 70 years old. | Oscar Caso-Maestro Carlos Jiménez-Romero Iago Justo-Alonso Jorge Calvo-Pulido David Lora-Pablos Alberto Marcacuzco-Quinto Félix Cambra-Molero Alvaro García-Sesma Marina Pérez-Flecha Carlos Munoz- Arce Carmelo Loinaz-Segurola Alejandro Manrique-Municio | 2018 | World Journal of Gastroenterology2018，24，47： | 2 |
| 2 | Pathophysiologieal role and therapeutic implications of inflammation in dia- betic nephropathy显示文摘 | Luis-Rodriguez D Martinez-Castelao A Gorriz J L De- Alvaro F Navarro-Gonzalez J F | 2012 | World J Diabetes2012，3，： | 1 |
| 3 | Epiderniology of diabetic nephropathy in Spain显示文摘 | Martinez-Castelao A De Alvaro F Gorriz JL | 2005 | Kidney lnt Suppl2005，，99： | 1 |
| 4 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 5 | Involvement of the Hexose Transporter Gene LeHT1 and of Sugars in Resistance of Tomato to Tomato Yellow Leaf Curl Virus显示文摘Dear Editor, Tomato yellow leaf curl virus (TYLCV) is a whitefly-transmitted geminivirus infecting tomato crops (Czosnek,2007).TYLCV-resistant (R) and susceptible (S) lines with the same genetic background have been bred using Solanum habrochaites as the resistance source.The gene(s) conferring resistance are unknown.Previously,we demonstrated that the hexose transpcrter gene LeHT1 is up-regulated upon infection in R plants and its silencing in R plants (RH) leads to the collapse of resistance (Eybishtz et al.,2010).To uncover the role of LeHT1 in resistance,we (1) analyzed the transcriptome reprogramming in leaves of S,R,and RH plants using a homedesigned microarray,before and 7 d after TYLCV inoculation (0,7 dpi),and (2) measured the concentration of sugars and their derivatives in S,R,and RH leaves at 1 and 7 dpi because LeHTI is transporting both glucose and fructose (McCurdy et al.,2010). | Dagan Sade Yariv Brotman Assa f Eybishtz Alvaro Cuadros-lnostroza Alisdair R. Fernie Lothar Willmitzer Henry Czosnek | 2013 | Molecular Plant2013，6，5： | 1 |
| 6 | The natural protein kinase C alpha mutant is present in human thyroid neoplasms 显示文摘 | Prevostel C Alvaro V Boisvilliers F | 1995 | Oncogene1995，11，4： | 1 |
| 7 | Building integration of PCM for natural cooling of buildings显示文摘 | Alvarez Servando Cabeza Luisa F Ruiz-Pardo Alvaro | 2013 | Applied Energy2013，109，： | 1 |
| 8 | Tillage and cropping intensification effects on soil aggregation: Temporal dynamics and controlling factors under semiarid conditions显示文摘 | ALVARO F J ARRUE J L GRACIA R | 2008 | Geoderma2008，145，： | 1 |
| 9 | Coagels from alkanoyl-6-O-ascorbic acid derivatives as drug carriers : Structure and rheology 显示文摘 | Santiago P Alvaro J K Laura F | 2003 | Farmaco2003，58，： | 1 |
| 10 | Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate显示文摘 | Santos-Carvalho A Elvas F Alvaro AR | 2013 | Cell Death Dis2013，16，4： | 1 |
| 11 | Thermal properties of sapwood of fruit trees as affected by anatomy and wa- ter potential:errors in sap flux density measurements based on heat pulse methods显示文摘 | Alvaro Lbpez-Bemal A Alcdntara E Villalobos F J | 2014 | Trees2014，28，6： | 1 |
| 12 | Mild liquid-phase Friedel-Crafts acylation of heteroaromatie compounds over zeolite Beta 显示文摘 | ALVARO V F D BRIGAS A F DEROUANE E G | 2009 | Journal of Molecular Catalysis A: Chemical2009，305，12： | 1 |
| 13 | Role of artificial intelligence in multidisciplinary imaging diagnosis of gastrointestinal diseases显示文摘The use of artificial intelligence-based tools is regarded as a promising approach to increase clinical efficiency in diagnostic imaging,improve the interpretability of results,and support decision-making for the detection and prevention of diseases.Radiology,endoscopy and pathology images are suitable for deep-learning analysis,potentially changing the way care is delivered in gastroenterology.The aim of this review is to examine the key aspects of different neural network architectures used for the evaluation of gastrointestinal conditions,by discussing how different models behave in critical tasks,such as lesion detection or characterization(i.e.the distinction between benign and malignant lesions of the esophagus,the stomach and the colon).To this end,we provide an overview on recent achievements and future prospects in deep learning methods applied to the analysis of radiology,endoscopy and histologic whole-slide images of the gastrointestinal tract. | M Alvaro Berbís José Aneiros-Fernández F Javier Mendoza Olivares Enrique Nava Antonio Luna | 2021 | World Journal of Gastroenterology2021，27，27： | 1 |
| 14 | Chronic fatigue syndrome: aetiology, diagnosis and treatmen 显示文摘 | Alfredo F Alvaro M | 2009 | BMC Psychiatry2009，9，1： | 1 |
| 15 | Displacement control in tunnels excavated by the NATM 3D numerical simulations显示文摘 | De Marcio M F Alvaro H M J De Andre P A | 2004 | Tunneling and Underground Space Technology2004，19，： | 1 |
| 16 | Dis- Placement Control in Tunnels Excavated by the NATM3D Numerical Simulations显示文摘 | De Marcio M F Alvaro H MJ De Andre P A | 2004 | Tunneling and Underground Space Technology2004，19，5： | 1 |
| 17 | Villous adenoma and invasive adenocarcinoma of the cervix显示文摘 | Alvaro T Nogales F | 1988 | Int J Gynecol Pathol1988，7，1： | 1 |
| 18 | Displacement control intunnels excavated by the NATM : 3-D numerical simulations显示文摘 | Marcio M F Alvaro H M Andre P A | 2004 | Tunnelling and Underground Space Technology2004，19，3： | 1 |
| 19 | Coagels from alkanoyl -6 - 0 - ascorbic acid derivatives as drug carriers : structure and rheology 显示文摘 | Santiago P Alvaro J K Laura F | 2003 | Farmaco2003，58，12： | 1 |
| 20 | Cor- tical Linear Lesions in Wernicke' s Encephalopathy: Can Diffusion-Weighted Imaging tterald Prognostic In- formation显示文摘 | Alvaro Machado Manuel Ribeiro Joao S F | 2010 | J Neuropsychiatry Clin Neurosci2010，22，： | 1 |
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