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| 1 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 2 | The web of human sexual contact显示文摘 | Rdling C R Amaral L A N | 2001 | Nature2001，411，6840： | 1 |
| 3 | Scaling behaviour in the growth of companies显示文摘 | Stanley M H R Amaral L A N Buldyrev S V Havlin S Leschhorn H Maass P Salinger M A Stanley H E | 1996 | Nature1996，379，： | 1 |
| 4 | A Review on Phase Change Energy Storage: Materials and Applications 显示文摘 | Mohammed M F Amar M K Siddique A K R etal | 2004 | Energy Conversion and Management2004，，15： | 1 |
| 5 | Development and verification of a one-dimensional ablation code including pyrolysis gas flow 显示文摘 | Amar A J Blackwell B F Edwards J R | 2009 | Journal of Thermophysics and Heat Transfer2009，23，1： | 1 |
| 6 | Ultrasonographic assessment of paediatric ocular emergencies: A tertiary eye hospital based observation显示文摘BACKGROUND: The purpose of this study is to assess the utility of ocular ultrasound B scan in the emergency at the fi rst point of care for detecting posterior segment and orbital pathologies in cases of paediatric ocular emergencies.METHODS: A prospective observational study involving 122 paediatric patients presenting to eye emergency over a period of ninety days were assessed with ultrasonography for the posterior segment as well as orbital pathology whenever indicated. The ocular ultrasound was performed gently over closed eyelids.RESULTS: Posttraumatic globe injuries were the most common indication for posterior segment evaluation, which constituted 80(65.57%) eyes. Among these 52 patients had an anechoic posterior segment and 28 patients had variable findings such as vitreous haemorrhage(8.19%), retinal detachment(6.55%), choroidal detachment(4.91%), posteriorly dislocated clear lens(0.81%) and retained intraocular foreign body(5.73%). Non-traumatic cases constituted around 42(34.42%) eyes, which included corneal ulcer(7.37%), retinoblastoma(6.55%), endophthalmitis(4.91%), extraocular muscle cysticercosis(4.91%), orbital cellulitis(4.09%), periocular haemorrhage(2.45%), proptosis(1.63%), paediatric cataract(1.63%) and cryptophthalmos(0.81%). No adverse events of performing the ultrasound was noted.CONCLUSION: First point ultrasonography in paediatric ocular emergencies is a cheap, portable and an effective tool in the assertion of signifi cant posterior segment and orbital diseases. | Amar Pujari Deepa R Swamy Rashmi Singh Ritika Mukhija Rohan Chawla Pradccp Sharma | 2018 | World Journal of Emergency Medicine2018，9，4： | 1 |
| 7 | Microtensile bond strength of a resin cement to glass infiltrated zirconiareinforced ceramic:The effect of surface conditioning显示文摘 | Amaral R Ozcan M Bottino MA | 2006 | Dent Mater2006，22，3： | 1 |
| 8 | Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications显示文摘 | Schloerb P R Amare M | 1993 | J Parenter Enteral Nutr1993，17，5： | 1 |
| 9 | Influence of different surface conditioning protocols on microtensile bond strength of self-adhesive resin cements to dentin显示文摘 | Pisani-Proenga J Erhardt MC Amaral R | 2011 | J Prosthet Dent2011，105，4： | 1 |
| 10 | Classes of Complex Networks Defined by Role-to-role Connectivi- ty Profiles显示文摘 | Guimera R Sales-Pardo M Amaral L A N | 2007 | Nature physics2007，3，1： | 1 |
| 11 | Trypsin-like enzyme from intestine and pyloric caeca of spotted goaffish ( Pseudupeneus maeulatus ) 显示文摘 | Souza A A G Amaral I P G Santo A R E | 2007 | Food Chem2007，100，4： | 1 |
| 12 | On-line fault detectionof aluminium electrolytic capacitors in step-down DC-DCconverters using input current and output voltage ripple显示文摘 | Amaral A M R Cardoso A J M | 2012 | IET Power Electronics2012，5，3： | 1 |
| 13 | Lies,damned lies and statistics显示文摘 | Amaral L A N Guimera R | 2006 | Nature Physics2006，2，2： | 1 |
| 14 | Functional cartography of complex metabolic networks 显示文摘 | Guimera R Amaral L A N | 2005 | Nature2005，433，7028： | 1 |
| 15 | Flavonoids and other phenolics from leaves of two Marlierea species (Myrtaceae)显示文摘 | Amaral A C F Kuster R M Bessa W S | 2001 | Biochem Syst Ecol2001，29，6： | 1 |
| 16 | Functional Cartography of Complex Metabolic Networks显示文摘 | Guimera R Amaral L A N | 2005 | Nature2005，433，7028： | 1 |
| 17 | An unusual water - soluble β - glucan from the basidioearp of the fungus Gmaoderma Resinaceum显示文摘 | AMARAL A E CARBONERO E R DE SIMAO R C G | 2008 | Carbohydrtne Polymers2008，72，3： | 1 |
| 18 | Optical properties of LiGaTiO4:Fe^3+显示文摘 | SOSMAN L P ABRITTA T AMARAL M R | 1998 | Solid State Commun1998，105，2： | 1 |
| 19 | The effects of process engineering on the performance of PLA and PHBV blends显示文摘 | MALAYA R Nanda MANJUSRI Misra AMAR K Monhanty | 2011 | Micromolecular Materials and Engineering2011，，296： | 1 |
| 20 | Postoperative rehabilitation protocols for Achilles tendon rupture: a Meta-analysis显示文摘 | AMAR A S CAROL S DAVID C R | 2006 | Clinical Orthopedics and Related Research2006，445，： | 1 |
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