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| 1 | Laparoscopic vs open partial colectomy in elderly patients:Insights from the American College of Surgeons- National Surgical Quality Improvement Program database显示文摘AIM: To compare the outcomes between the laparoscopic and open approaches for partial colectomy in elderly patients aged 65 years and over using the American College of Surgeons- National Surgical Quality Improvement Program(ACS NSQIP) database. METHODS: The ACS NSQIP database for the years 2005-2011 was queried for all patients 65 years and above who underwent partial colectomy. 1:1 propensity score matching using the nearest- neighbor method was performed to ensure both groups had similar preoperative comorbidities. Outcomes including postoperative complications, length of stay and mortality were compared between the laparoscopic and open groups. χ2 and Fisher's exact test were used for discrete variables and Student's t-test for continuous variables. P < 0.05 was considered significant and odds ratios with 95%CI were reported when applicable. RESULTS: The total number of patients in the ACS NSQIP database of the years 2005-2011 was 1777035. We identified 27604 elderly patients who underwent partial colectomy with complete data sets. 12009(43%) of the cases were done laparoscopically and15595(57%) were done with open. After propensity score matching, there were 11008 patients each in the laparoscopic(LC) and open colectomy(OC) cohorts. The laparoscopic approach had lower post-operative complications(LC 15.2%, OC 23.8%, P < 0.001), shorter length of stay(LC 6.61 d, OC 9.62 d, P < 0.001) and lower mortality(LC 1.6%, OC 2.9%, P < 0.001). CONCLUSION: Even after propensity score matching, elderly patients in the ACS NSQIP database having a laparoscopic partial colectomy had better outcomes than those having open colectomies. In the absence of specific contraindications, elderly patients requiring a partial colectomy should be offered the laparoscopic approach. | Umashankkar Kannan Vemuru Sunil K Reddy Amar N Mukerji Vellore S Parithivel Ajay K Shah Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastroenterology2015，21，45： | 3 |
| 2 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 3 | Handgrip strength at ad- mission and time to discharge in medical and surgical inpatients 显示文摘 | Mendes J Azevedo A Amaral T F | 2013 | Journal of Parenteral and Enteral Nutrition2013，，： | 1 |
| 4 | Resveratrol attenuates cisplatin-induced nephrotoxicity in rats显示文摘 | do AMARAL C L FRANCESCATO H D C COIMBRA T M | 2008 | Archives of Toxicology2008，82，6： | 1 |
| 5 | Molecular dynamics simulations of laser-induced incandescence of soot using an extended reaxff reactive force field显示文摘 | Amar M K Adri C T van D Alexei Y | 2010 | J Phys Chem A2010，114，12： | 1 |
| 6 | Fluorescence in situ hybridization : a highly efficient technique of molecular diagnosis and predication for disease course in patients with myeloid leukemias 显示文摘 | Amare P S Baisane C Saikia T | 2001 | Cancer Genet Cytogenet2001，31，2： | 1 |
| 7 | Optical properties of LiGaTiO4:Fe^3+显示文摘 | SOSMAN L P ABRITTA T AMARAL M R | 1998 | Solid State Commun1998，105，2： | 1 |
| 8 | Antimicrobial ellagitannin of punica granatumfruits显示文摘 | MACHADO T B LEAL I C AMARAL A C | 2002 | J Braz Chem Soc2002，13，5： | 1 |
| 9 | Pre-dictive value of serum prolactin levels measured immediate-ly after transsphenoidal surgery显示文摘 | COULDWELL W T CHEN J C | 2002 | J Neurosurg2002，97，2： | 1 |
| 10 | Fluorescence in situ hybridization:a highly efficient technique of molecular diagnosis and predication for disease course in patients with myeloid leukemias显示文摘 | AMARE P S BAISANE C SAIKIA T NAIR R GAWADE H ADVANI S | 2001 | Cancer Genet Cytogenet2001，131，2： | 1 |
| 11 | Taurine supplementation restores glucose and carbachol-induced insulin secretion in islets from low-protein diet rats:involvement of Ach-M3R,Synt 1 and SNAP-25 proteins显示文摘 | BATISTA T M RIBEIRO R A AMARAL A G | 2012 | Journal of Nutritional Biochemistry2012，23，： | 1 |
| 12 | Metabolic endotoxemia initiates obesity and insulin resistance 显示文摘 | Cani PD Amar J Iglesias MA Poggi M Knauf C Bastelica D Neyrinck AM Fava F Tuohy KM Chabo C Waget A Delm6e E Cousin B Sulpice T Chamontin B Ferrieres J Tanti JF Gibson OR Casteilla L Delzenne NM Alessi MC Burcelin R | 2007 | Diabetes2007，56，7： | 1 |
| 13 | Analysis of Honey Phenolic Acid by HPLC, Its Application to Honey Botanical Charaterization显示文摘 | Andrade P Ferreres F Amaral M T | 1997 | J Liq Chrom & Rel Technol1997，20，14： | 1 |
| 14 | Ascending aorta dissecting aneurysm in a teenager with isolated systemic hypertension显示文摘 | Manso P H Amaral F T Vicente W V | 2007 | Int J Cardiol2007，118，3： | 1 |
| 15 | Fermentative and chemical characteristics of marandugrass silage submitted to four compaction pressures显示文摘 | Camargo do Amaral R Bernardes T F Siqueira G R | 2007 | Revista Brasileira de Zootecnia2007，，3： | 1 |
| 16 | Brazil- ian phytopharmaceuticals evaluation against hospital bae- teria显示文摘 | Machado T B Leal I C R Amaral A C F | 2005 | Phyto Ther Res2005，19，： | 1 |
| 17 | Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene显示文摘 | Grandi T da Silva CM Amaral KM Picon PD Costi C da Fre NN Fiegenbaum M Niel C Rossetti ML | 2013 | Mem Inst Oswaldo Cruz2013，108，1： | 1 |
| 18 | A review on pineapple leaf fibers, sisal fibers and their biocomposites 显示文摘 | Supriya M Amar K M Lawrence T D | 2004 | Macromolecular Materials and Engineering2004，289，： | 1 |
| 19 | Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth显示文摘 | PIMENTA AMARAL T M DA SILVA FREIRE A R CARVALHO A L | 2004 | Oral Oncol2004，40，： | 1 |
| 20 | Fluorescence in situhybridization:a highly efficient technique of molecular diagnosis and predication for disease course in patients with myeloid leukemias显示文摘 | Amare PS Baisane C Saikia T | 2001 | Cancer Genet Cytog-enet2001，131，2： | 1 |
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