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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/ SCID engrafting potential显示文摘 | Cheung AM Wan TS Eeung JC | 2007 | Leukemia2007，21，7： | 1 |
| 3 | The prognostic impact of the time interval to recurrence for the mortality in recurrent colorectal cancer显示文摘 | Kaiser AM Kang JC Chan LS | 2006 | Colorectal Dis2006，8，8： | 1 |
| 4 | Tuberculosis transmitted through transplantation显示文摘 | Kearns AM Magee JG | 2001 | J Infect2001，43，： | 1 |
| 5 | Cardiac carbohydrate metabolism in Zucker diabetic fatty rats显示文摘 | Chatham JC Seymour AM | 2002 | Cardiovasc Res2002，55，1： | 1 |
| 6 | Maternal plasma levels of vascular endothelial growth factor in normotensive pregnancies and in pregnancies complicated by pre - eclampsia 显示文摘 | Sharkey AM Cooper JC Balmforth JR | 1996 | Eur J Clin Invest1996，26，12： | 1 |
| 7 | Laparoscopyassisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial 显示文摘 | Lacy AM Garcia Valdecasas JC Delgado S etal | 2002 | Lancet2002，359，9325： | 1 |
| 8 | The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations显示文摘 | Kelsey AM Arango JC | 1995 | Histopathology1995，26，2： | 1 |
| 9 | Aging ofcerebral white matter: a review of MRI findings显示文摘 | Gunning-Dixon FM Brickman AM Cheng JC | 2009 | Int J GeriatrPsychiatry2009，24，2： | 1 |
| 10 | Laparoscopy-assisted colectomy versus open colectomy for treatment of nonmetastatic colon cancer:a randomised trial显示文摘 | Lacy AM García-Valdecasas JC Delgado S | | 0，，9325： | 1 |
| 11 | The pathogenesis of acute pulmonary edema associated with hypertension显示文摘 | Gandhi SK Powers JC Nomeir AM | 2001 | N EngI J Med2001，344，： | 1 |
| 12 | Sex hormone binding globulin in postmenopausal women : a predictor of osteoporo- sis superior to endogenous oestrogens 显示文摘 | van Hemert AM Birkenhager JC de Jong FH | 1989 | Clin Endocrinol ( Oxf)1989，4，： | 1 |
| 13 | Memory intervention for persons with dementia显示文摘 | Camp JC Foss JW O'Hanlon AM | 1996 | App Cogn Psychol1996，10，： | 1 |
| 14 | Laparoscopy assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial显示文摘 | Lacy AM Garcia-Valdecasas JC Delgado S | 2002 | Lancet2002，359，9325： | 1 |
| 15 | Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals 显示文摘 | VINGGAARD AM JOERGENSEN EC Larsen JC | 1999 | Toxicol Appl Pharmacol1999，155，2： | 1 |
| 16 | Induction of adiponectin in skeletal muscle by inflammatory cytokines: in vivo and in vitro studies 显示文摘 | Delaigle AM Jonas JC Bauche IB | 2004 | Endocrinology2004，145，： | 1 |
| 17 | Coronary artery aneurysms in patients with hyper IgE recurrent infection syndrome显示文摘 | Ling JC Freeman AF Gharib AM | 2007 | Clin Immunol2007，122，3： | 1 |
| 18 | Inflammatory responses in two connonly used rat models for c tooth movement:comparison with ligature-induced petiodontitis显示文摘 | Xie R Kuijpers-Jagtman AM Maltha JC | | 0，，： | 1 |
| 19 | Gucocort icosteroid s increase beta2 adrenerg ic receptor transcript ion in hum an lung显示文摘 | Mak JC N ish ikaw aM Barnes PJ | 1995 | Am J Physiol1995，268，11： | 1 |
| 20 | Autologous translocation of the choroid and retinal pigment epithelium in patients with geographic atrophy 显示文摘 | Joussen AM Joeres S Fawzy N Heussen F Llacer H Meurs JC | 2007 | Oph- thalmology2007，114，3： | 1 |
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