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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 3 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 4 | Laparoscopic colon resection:a case report显示文摘 | Cooperman AM Katz V Zimmon D | 1991 | J Laparoendose Surg1991，1，4： | 1 |
| 5 | Gastrointestimd stromal tumors frequency, malignancy, and new prognostic factors : the experi- ence of a single institution 显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol Res Pract2008，204，4： | 1 |
| 6 | Myocardial function, energy provi- sion,and camitine deficiency in experimentai uremia 显示文摘 | Reddy V Bhandari S Seymour AM | 2007 | J Am Soc Nephrol2007，18，： | 1 |
| 7 | Herbicide resistance fertile transgenic wheat plants obtained by microprojectile bombardment of regenerable emhryogenic callus 显示文摘 | Vasil V AM Castillo ME Fromm | 1992 | Bio/Technology1992，10，： | 1 |
| 8 | Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced ischemia显示文摘 | Zeiher AM Krause T Schachinger V | 1995 | Circulation1995，91，： | 1 |
| 9 | Effieacy and tolerability of combined treatment with L-earuitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus显示文摘 | Solfrizzi V Capurso C Colacieeo AM | 2006 | Atheroselerosis2006，188，2： | 1 |
| 10 | Circulating biomarkers of cognitive decline and dementia显示文摘 | Solfrizzi V D'Introno A Colacicco AM | 2006 | Clin Chim Acta2006，364，12： | 1 |
| 11 | Human papillomaviruses and genital disease显示文摘 | Ahmed AM Madkan V Tyring SK | 2006 | Dermatol Clin2006，24，2： | 1 |
| 12 | Ultrasonic acti- vation and chemical modification of photosensitizers en-hances the effects of photodynamic therapy against Entero- coccus faecalis root - canal isolates 显示文摘 | Tennert C Drews AM Wahher V | 2015 | Photodiag Photo- dynam Ther2015，12，2： | 1 |
| 13 | Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease显示文摘 | SCHLCHINGER V BRITTEN M B ZEIHER AM | 2000 | Circulation2000，101，： | 1 |
| 14 | A genomic explanation connecting 'Mediterranean diet',olive oil and cancer:Oleic acid,the main monounsaturated Fatty acid of olive oil,induces formation of inhibitory'PEA3 transcription factor-PEA3 DNA binding site' complexes at the Her-2/neu(erbB-2)oncogene promoter in breast,ovarian and stomach cancer cells显示文摘 | ADRIANA P LUCIANO V | 2006 | European Journal of Cancer2006，42，： | 1 |
| 15 | The impact of insulin secretion on the ovarian response to exogenous gonadotropins in polycystic ovary syndrome 显示文摘 | Fulghesu AM Villa P Pavone V | 1997 | J Clin Endocrinol Meta1997，82，2： | 1 |
| 16 | Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency 显示文摘 | Eraranta A Kurra V Tahavanainen AM | 2008 | J Hypertens2008，26，： | 1 |
| 17 | Beta-thromboglobulin and platelet in unstable angina显示文摘 | Bulkiewicz AM Kemona H Dymicka-Piekarska V | 2003 | Kardiol Pol2003，58，6： | 1 |
| 18 | Misoprostol for second trimester pregnancy termination in women with prior caesaren:a sys-tematic review显示文摘 | Berghella V Airoidi J 0'Neill AM et a1 | 2009 | BJOG2009，116，9： | 1 |
| 19 | A central role for inflammation in the pathogenesis of diabetic retinopathy显示文摘 | Joussen AM Poulaki V Le ML | 2004 | FASEB2004，18，12： | 1 |
| 20 | Engineering and expression of the intracellular domain of insulinoma-associated tyrosine phosphatase (IA-2ic), a type 1 diabetes autoantigen, in plants 显示文摘 | Mett V Shamloul AM Hirai H | 2007 | Transgenic Res2007，16，1： | 1 |
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