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| 1 | Helicobacter pylori vaccination:Is there a path to protection?显示文摘Helicobacter pylori(H.pylori)is a pathogenic,extracellular bacterium that colonizes the stomach in approximately 50%of the world population.It strongly interacts with the gastric epithelium and mostly causes asymptomatic gastritis.The colonization of H.pylori leads to ulcer development in around 20%of infected patients and may progress to gastric cancer or mucosaassociated lymphoid tissue lymphoma in 1%.Thus,H.pylori is the major cause of gastric cancer worldwide.It has been classified as a classⅠcarcinogen by the World Health Organization.Since its discovery in the early eighties by Warren and Marshall,research has been focused on the investigation of H.pylori biology,host-pathogen interaction,prevention and treatment.Although H.pylori induces a strong humoral and local cellular immune response,the pathogen is not cleared and establishes a chronic infection after encounters in childhood.The ability to colonize the stomach is mediated by several virulence factors that change the host environment,promote adhesion to the epithelium,influence the gastric inflammation and induce immune evasion.H.pylori can be eradicated by antibiotic treatment in combination with a proton-pump inhibitor,but efficacy is decreasing.Current therapies are expensive,have side effects and contribute to increasing antibiotic resistance,underlining the need for novel therapeutics. | Florian Anderl Markus Gerhard | 2014 | World Journal of Gastroenterology2014，20，34： | 4 |
| 2 | Biphoton-indueed refractive index change in 4-amino-4' -nitroazobenzene/polycarbonate 显示文摘 | BACH H ANDERLE K FUHRMANN T | 1996 | J Phys Chem1996，100，： | 1 |
| 3 | Radiologic analysis of arthritis in rats after systemic injection of streptococcal cell walls显示文摘 | Clark R L Cuttino J T Jr Anderle S K | 1979 | Arthritis Rheum1979，22，1： | 1 |
| 4 | Posttraumatic anterior-inferior instability of the shoulder: arthroscopic findings and clinical correlations显示文摘 | SPATSCHIL A LANDSIEDL F ANDERL W | 2006 | Arch Orthop Trauma Surg2006，126，4： | 1 |
| 5 | Chlorophyll breakdown in senescent chloroplasts (cleavage of pheophorbide a in two enzymic steps)显示文摘 | Rodoni S M W Anderl M Krautler B | 1997 | Plant Physiol1997，，115： | 1 |
| 6 | Modeling with constraints:theo-retical foundation and application显示文摘 | ANDERL R MENDGEN R | | 0，，03： | 1 |
| 7 | Primary stability with tibial press-fit fixation of patellar ligament graft:An experimental study in ovine knees显示文摘 | Boszotta H Anderl W | 2001 | Arthroseopy2001，17，9： | 1 |
| 8 | Modeling with constraints:theoretical foundation and application显示文摘 | ANDERL R MENDGEN R | 1996 | Computer-Aided Design1996，28，4： | 1 |
| 9 | Role of antibiotic penetration limitation in KlebsieUa pneumoniae biofilm resistance to ampicillin and ciprofloxacin 显示文摘 | Anderl J N Franklin M J Stewart P S | 2000 | Antimicrob Agents Chemother2000，44，： | 1 |
| 10 | Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes显示文摘 | Anderle P Sengstag T Mutch DM | 2005 | BMC Genomics2005，6，： | 1 |
| 11 | Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes显示文摘 | Anderle P Sengstag T Mutch DM | 2005 | BMC Genomics2005，6，1： | 1 |
| 12 | Advanced modelling for CAD/CAM systems显示文摘 | Hans G rabowski Reiner Anderl Michael J Pratt | 1991 | Research Reports ESPRIT1991，7，1： | 1 |
| 13 | Carbon effect on the phase struc- ture and the hardness of RF sputtered zirconia films显示文摘 | Laidani N Micheli V Anderle M | 2001 | Thin Solid Films2001，，382： | 1 |
| 14 | Role of nutrient limitation and stationary-phase existence in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin显示文摘 | Anderl JN Zahller J Roe F | 2003 | Antimicrob Agents Chemother2003，47，4： | 1 |
| 15 | Detection of p16,RB,CDK4,and p53 gene deletion and amplification by fluorescence in situ hyhridization in 96 gliomas显示文摘 | Perry A Anderl K Borell TJ | 1999 | Am J Clin Pathol1999，112，6： | 1 |
| 16 | The neural substrates of the affective processing in depressed patients treated with venlafaxine显示文摘 | Davidson R J Irwin W Anderle MJ | 2003 | Am J Psychiatry2003，160，1： | 1 |
| 17 | The Ulnar Nerve as Vascularized Nerve Transplant显示文摘 | K. Künzel C. Fischer H. Anderl | 1986 | J reconstr Microsurg1986，，03： | 1 |
| 18 | Enzyme - catalyzed partial deacetylation of 1,6 - mdaydro - 2,3,4 - tri - O - acetyl -β - D - glucopyranose显示文摘 | ZEMEK J KUCAR S ANDERLE D | 1987 | Collect Czech Chem Commun1987，52，： | 1 |
| 19 | Role of nutrient limitation and stationary-phase existence in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin显示文摘 | Zahller J Roe F | 2003 | Antimicrob Agents Chemother2003，47，： | 1 |
| 20 | Modeling with constraints: theoretical foundation and application显示文摘 | Anderl R | 1996 | CAD1996，28，3： | 1 |
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