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| 1 | Whole genome scan detects an allelic variant of fad2 associated with increased oleic acid levels in maize显示文摘 | André Beló Peizhong Zheng Stanley Luck Bo Shen David J. Meyer Bailin Li Scott Tingey Antoni Rafalski | 2008 | Molecular Genetics and Genomics2008，，1： | 1 |
| 2 | Production, analysis and in vivo evaluation of novel angiotensin-I-converting enzyme inhibitory peptides from bovine casein显示文摘 | Zhanmei Jiang Bo Tian André Brodkorb Guicheng Huo | 2010 | Food Chemistry2010，，3： | 1 |
| 3 | Controlling persistent organic pollutants–what next? 1 Correspondence to: Nicole G Weavers, ETAF, European Training and Assessment Foundation, PO Box 182, 6700 AD, Wageningen, The Netherlands. Tel.: +31-317-484924; Fax: +31-317-484941 1显示文摘 | Harry W. Vallack Dick J. Bakker Ingvar Brandt Eva Brostr?m-Lundén Abraham Brouwer Keith R. Bull Clair Gough Ramon Guardans Ivan Holoubek Bo Jansson Rainer Koch Johan Kuylenstierna André Lecloux Donald Mackay Patrick McCutcheon Paolo Mocarelli Rob D.F. Taa | 1998 | Environmental Toxicology and Pharmacology1998，，3： | 1 |
| 4 | Myrosinase: gene family evolution and herbivore defense in Brassicaceae显示文摘 | Lars Rask Erik Andréasson Barbara Ekbom Susanna Eriksson Bo Pontoppidan Johan Meijer | 2000 | Plant Molecular Biology2000，，1： | 1 |
| 5 | Whole genome scan detects an allelic variant of fad2 associated with increased oleic acid levels in maize显示文摘 | André Beló Peizhong Zheng Stanley Luck Bo Shen David J. Meyer Bailin Li Scott Tingey Antoni Rafalski | 2008 | Molecular Genetics and Genomics2008，，： | 1 |
| 6 | Whole genome scan detects an allelic variant of fad2 associated with increased oleic acid levels in maize显示文摘 | André Beló Peizhong Zheng Stanley Luck Bo Shen David J. Meyer Bailin Li Scott Tingey Antoni Rafalski | 2008 | Molecular Genetics and Genomics2008，，1： | 1 |
| 7 | Controlling persistent organic pollutants–what next? 1 Correspondence to: Nicole G Weavers, ETAF, European Training and Assessment Foundation, PO Box 182, 6700 AD, Wageningen, The Netherlands. Tel.: +31-317-484924; Fax: +31-317-484941 1显示文摘 | Harry W. Vallack Dick J. Bakker Ingvar Brandt Eva Brostr?m-Lundén Abraham Brouwer Keith R. Bull Clair Gough Ramon Guardans Ivan Holoubek Bo Jansson Rainer Koch Johan Kuylenstierna André Lecloux Donald Mackay Patrick McCutcheon Paolo Mocarelli Rob D.F. Taa | 1998 | Environmental Toxicology and Pharmacology1998，，3： | 1 |
| 8 | Pharmacodynamics and pharmacokinetics of the novel PAR-1 antagonist vorapaxar (formerly SCH 530348) in healthy subjects显示文摘 | Teddy Kosoglou Larisa Reyderman Renger G. Tiessen André A. Vliet Robert R. Fales Robert Keller Bo Yang David L. Cutler | 2012 | European Journal of Clinical Pharmacology2012，，3： | 1 |
| 9 | Evidence-based biomaterials research显示文摘The fast development of biomaterials science and engineering has generated significant number of studies and publications as well as tremendous amount of research data.A methodology is needed to translate such research data and results to validated scientific evidence.This article for the first time proposes the concept and methodology of evidence-based biomaterials research,which is to use evidence-based research approach represented by systematic reviews to generate evidence for answering scientific questions related to biomaterials.After briefly introducing the advancement of biomaterials since 1950s,the scientific and engineering nature of biomaterials are discussed along with the roadmap of biomaterials translation from basic research to commercialized medical products,and the needs of scientific evidence.Key information of the evidence-based approach such as its origination from evidence-based medicine,levels of evidence,systematic review and meta-analysis,differences between systematic and narrative reviews is then highlighted.Applications with a step-by-step procedure of conducting evidence-based biomaterials research,three examples of biomaterials research using evidence-based approach to generate scientific evidence,and opportunities and challenges of evidence-based biomaterials research are presented.With its notable impact on the practice of medicine,the evidence-based approach is also expected to make influential contributions to the biomaterials field. | Kai Zhang Bin Ma Kaiyan Hu Bo Yuan Xin Sun Xu Song Zhonglan Tang Hai Lin Xiangdong Zhu Yufeng Zheng Andres JGarcía Antonios GMikos James MAnderson Xingdong Zhang | 2022 | Bioactive Materials2022，7，9： | 0 |
| 10 | Rutgeerts评分与克罗恩病末端回肠造口术后复发的相关性显示文摘背景:克罗恩病(CD)患者术后(包括末端回肠造口术)会出现复发。对于回结肠切除术患者,术后可以通过回结肠镜进行Rutgeerts评分,从而预测术后CD的临床复发。而通过回肠造口进行的回肠镜评估对于术后CD复发的预测价值,目前尚未见报道。本研究旨在评估回肠镜下Rutgeerts评分对于CD患者末端回肠造口术后疾病复发的预测价值。方法:共有73例行末端回肠造口术的CD患者纳入研究,所有入组病例术后均在本中心接受了至少2次的回肠镜评估。基于Rutgeerts评分对新末端回肠的黏膜炎症程度进行分级。主要结局指标是由于疾病复发需要行内镜扩张治疗或再次手术治疗,次要结局指标是CD相关住院治疗和需要升级CD治疗药物。结果:本组病例CD发病至行末端回肠造口术的中位间期为9年(四位分间距:413年),造口术至首次回肠镜检查的中位间期为28月(四位分间距:1193月)。对靠近造口处的新末端回肠进行Rutgeerts评分,并据此将患者分为两组:Rutgeerts评分0分者为正常评分组(25例),≥1分者为异常评分组(48例)。异常评分组患者疾病复发(92%vs 27%)、需要行内镜扩张治疗(40%vs 10%)、再次肠道手术(68%vs 15%)、住院治疗(80%vs 23%)以及CD治疗药物升级的概率高于正常评分组。事件发生时间(time-to-event)分析显示,对手术至首次内镜评估的时间、疾病病程和患者性别等因素进行调整后,异常评分组患者需要行内镜扩张(HR=1.5,95%CI:1.09–1.9)、再次肠道手术(HR=1.5,95%CI:1.2–1.8)和住院治疗(HR=1.3,95%CI:1.1–1.6)的风险显著增高。多因素分析显示,对手术至初次内镜评估的时间和患者年龄进行调整后,异常评分组患者需要升级CD治疗药物的风险亦明显增高(OR=5.3,95%CI:1.7–16.5;P=0.004)。结论:Rutgeerts评分可用以预测末端回肠造口患者的CD复发。回肠镜评估的高Rutgeerts评分患者预后不良。基于回肠镜的Rutgeerts评分是末端回肠造口术后疾病监测的有效工具。 | Vasutakarn Chongthammakun Andre Fialho Andrea Fialho Rocio Lopez Bo Shen | 2017 | Gastroenterology Report2017，5，4： | 0 |
| 11 | 小肠细菌过度生长与深静脉血栓形成的关系显示文摘目的:小肠细菌过度生长(SIBO)会导致一些疾病。SIBO与深静脉血栓形成(DVT)的关系尚无报道。本研究旨在调查SIBO患者DVT的发生率及危险因素。方法:收集Cleveland Clinic胃肠动力实验室数据库2008-2014年间接受葡萄糖氢/甲烷呼吸试验(诊断SIBO)和多普勒超声检查(诊断可疑DVT)的321例患者纳入研究,排除插管引起的DVT病例。主要研究指标是本组患者DVT的发生率和危险因素(包括SIBO)。结果:本组321例入组患者中144例(44.9%)检测出SIBO,53例(16.5%)经超声检查发现DVT。201例患者在DVT评估之前进行SIBO评估,呼吸试验至超声检查的中位时间为27月(四分位间距:11.0-45.0月);120例在DVT评估之后进行SIBO评估,超声检查至呼吸试验的中位时间为30月(四分位间距:11.8-54.3月)。单因素分析显示,DVT的发生与血栓栓塞事件家族史(35.8%vs 16.0%,P=0.001)、慢性肾病(26.4%vs 16.013.4%,P=0.019)和SIBO(69.8%vs 39.9%,P<0.001)显著相关。多因素分析显示,血栓栓塞事件家族史(OR=3.39,95%CI:1.67-6.8,P<0.001)、慢性肾病(OR=2.23,95%CI:1.04-4.74,P=0.037)和SIBO(OR=3.27,95%CI:1.70-6.32,P<0.001)可独立预测DVT的发生。结论:SIBO与DVT的发生密切相关,这种关系值得进一步研究。 | Andre Fialho Andrea Fialho Aldo Schenone Prashanthi Thota Arthur McCullough Bo Shen | 2016 | Gastroenterology Report2016，4，4： | 0 |
| 12 | 原发性硬化性胆管炎会进一步导致回肠储袋肛管吻合患者维生素D缺乏显示文摘目的:溃疡性结肠炎(UC)患者回肠储袋肛管吻合(IPAA)术后常出现维生素D缺乏。IPAA患者出现原发性硬化性胆管炎(PSC)后维生素D水平是否会进一步降低,目前仍不明了。本研究的目的是评估PSC是否是UC患者IPAA术后维生素D缺管的一个危险因素。方法:在该病例对照研究中,74例出现PSC的IPAA患者纳入研究组,79例未出现PSC的IPAA患者作为对照组。44项指标被纳入多因素逻辑回归模型中进行分析。结果:153例患者入组研究,其中研究组74例(48.4%),对照组79例(51.6%)。研究组维生素D水平是(18.961.4)ng/dL,明显低于对照组的(30.361.7)ng/dL(P=0.011)。共有65例(42.5%)患者出现维生素D缺乏,其中49例(75.4%)合并PSC。多因素分析显示,PSC的出现(OR=7.56,95%CI:2.29-24.08;P=0.001)和维生素D的补充(OR=2.58,95%CI:1.57-9.19;P=0.018)与维生素D缺乏密切相关。结论:PSC的出现是UC患者IPAA术后维生素D缺乏的独立危险因素。这些患者应该被筛查出来,以对其维生素D水平进行严密监测。 | Andre Fialho Andrea Fialho Gursimran Kochhar Bo Shen | 2016 | Gastroenterology Report2016，4，4： | 0 |
| 13 | Individually resolved luminescence from closely stacked GaN/AlN quantum wells显示文摘Investigating closely stacked GaN/AlN multiple quantum wells(MQWs)by means of cathodoluminescence spectroscopy directly performed in a scanning transmission electron microscope,we have reached an ultimate spatial resolution ofσCL=1.8 nm.The pseudomorphically grown MQWs with high interface quality emit in the deep ultraviolet spectral range.Demonstrating the capability of resolving the 10.8 nm separated,ultra-thin quantum wells,a cathodoluminescence profile was taken across individual ones.Applying a diffusion model of excitons generated by a Gaussian-broadened electron probe,the spatial resolution of cathodoluminescence down to the free exciton Bohr radius scale has been determined. | BOWEN SHENG GORDON SCHMIDT FRANK BERTRAM PETER VEIT YIXIN WANG TAO WANG XIN RONG ZHAOYING CHEN PING WANG JüRGEN BLASING HIDETO MIYAKE HONGWEI LI SHIPING GUO ZHIXIN QIN ANDRéSTRITTMATTER BO SHEN JüRGEN CHRISTEN XINQIANG WANG | 2020 | Photonics Research2020，8，4： | 0 |
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