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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | Delayed intracranial hypertension: relationship to leukocyte count 显示文摘 | Souter MJ Andrews PJ Pereirinha MR | 1999 | Crit Care Med1999，27，1： | 1 |
| 3 | Cortisol metabolism in healthy young adults:sexual dimorphism in activities of A-ring reductases,but not 11 beta hydroxysteroid dehydrogenases显示文摘 | Finken MJ Andrews RC Andrew R | 1999 | J Clin Endocrinol Metab1999，84，9： | 1 |
| 4 | Activating and in- hibitory receptors of natural killer cells显示文摘 | Pegram HJ Andrews DM Smyth MJ | 2011 | Immunol Cell Biol2011，89，2： | 1 |
| 5 | Gender's role in respons-es to infertility显示文摘 | Abbey MJ Antonia GY Andrews T | 1991 | Psychol Women Q1991，15，2： | 1 |
| 6 | Superficial soft-tissue masses : analysis , diagnosis , and differential considerations 显示文摘 | Beaman FD Kransdorf MJ Andrews TR | 2007 | Radiographics2007，27，2： | 1 |
| 7 | Characterization of rat CD4 T cell clones specific for the major surface glycoprotein of Pneumocystisearinii显示文摘 | Theus SA Andrews RP Linke MJ | 1997 | J Eukaryot Microbiol1997，44，2： | 1 |
| 8 | Detection and management of tracheal steno- sis following cuffed tube tracheostomy显示文摘 | Pearson FG Andrews MJ | 1971 | Ann Thorac Surg1971，12，4： | 1 |
| 9 | Proliferative and cytokine responses to a major surface glycoprotein of Pneumocystis carinii显示文摘 | Theus SA Linke MJ Andrews RP | 1993 | Infect Immun1993，61，11： | 1 |
| 10 | (3,3-Diflu- oro-pyrrolidin-1 -yl ) --methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor显示文摘 | Arnmirati MJ Andrews KM BOYER DD etal | 2009 | Bioorg Med Chem Lett2009，19，7： | 1 |
| 11 | Generation and characterization of E1/E2a/ES/E4-deficient adenoviral vectors encoding human factor VIII 显示文摘 | Andrews JL Kadan MJ Gorziglia MI | 2001 | Mol Ther2001，3，3： | 1 |
| 12 | Studies on drug release kinetics from Carbomer matrices显示文摘 | Durrani MJ Andrews A Whitaker R | 1994 | Drug Dev Ind Pharm1994，20，15： | 1 |
| 13 | Proliferative and cy tokine responses to a major surface glycoprotein of Pneumocystis carinii显示文摘 | Theus SA Linke MJ Andrews RP | 1993 | Infect Immun1993，61，： | 1 |
| 14 | Characteracterizati on of rat CD4 T cell clones specific for the major surface glycoprotein of Pne umocystis carinii显示文摘 | Theus SA Andrews RP Linke MJ | 1997 | J Eukaryot Microbiol1997，44，： | 1 |
| 15 | Relationship be-tween C02 assimilation, photosynthetic electron transportand active 02 metabolism in leaves of maize in the fieldduring periods of low temperature 显示文摘 | Fryer MJ Andrews JR Oxborough K | 1998 | Plant Physiol1998，116，： | 1 |
| 16 | Histonc deacetylase inhibitors in inflammatory disease显示文摘 | Halili MA Andrews MR Sweet MJ | 2009 | Curt' Top Med Chem2009，9，3： | 1 |
| 17 | Immune-correlates analysis of an HIV-1 vaccine efficacy trial 显示文摘 | Haynes BF Gilbert PB McElrath MJ Zolla-Pazner S Tomaras GD Alam SM Evans DT Montefiori DC Kar- nasuta C Sutthent R Liao HX DeVico AL Lewis GK Williams C Pinter A Fong Y Janes H DeCamp A Huang Y Rao M Billings E Karasavvas N Robb ML Ngauy V de Souza MS Paris R Ferrari G Bailer RT Soderberg KA Andrews C Berman PW Frahm N De Ro- sa SC Alpert MD Yates NL Shen X Koup RA Pitisut- tithum P Kaewkungwal J Nitayaphan S Rerks-Ngarm S Michael NL Kim JH | 2012 | N Engl J Med2012，366，14： | 1 |
| 18 | Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events 显示文摘 | O'Donnell MJ Salim Y Andrew M | 2011 | Jama Journal of the American Medical Association2011，306，20： | 1 |
| 19 | Mitochondrial abnormalities in ageing macular photoreceptors显示文摘 | Barton MJ Johnson MA Andrews RM | 2001 | Invest Ophthalmol Vis Sci2001，42，12： | 1 |
| 20 | (3,3-Di- fluoropyrrolidin- 1-yl) - ( ( 2 S, 4S) -4- (4- (pyrimidin-2-yl) piperazin-l-yl) pyrrolidin-2-yl)-methanone: a potent, se- lective, orally active dipeptidyl peptidase IV inhibitor显示文摘 | Ammirati MJ Andrews KM Boyer DD | 2009 | Bioorg Med Chem Lett2009，19，7： | 1 |
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