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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Mechanistic seismic damage model for reinforced concrete 显示文摘 | Park Y J Ang A H S | 1985 | ASCE Journal of Structural Engineering1985，111，4： | 1 |
| 3 | Seismic damage analysis of reinforced concrete buildings显示文摘 | Park Y J Ang H S | 1985 | ASCE Journal of Structural Engineering1985，111，4： | 1 |
| 4 | Total factor carbon e-mission performance; a malmquist index analysis显示文摘 | ZHOU P ANG B W HAN J Y | 2010 | En-ergy Economics2010，32，1： | 1 |
| 5 | Total factor carbon emission performance: a malmquist index analysis显示文摘 | Zhou P Ang B W Han J Y | 2010 | Energy Economics2010，32，1： | 1 |
| 6 | Total Factor Carbon Emission Performance: A Malmquist Index Analysis 显示文摘 | Zhou P Ang ]3 W Han J Y | 2010 | Energy Economics2010，32，1： | 1 |
| 7 | Seismic damge Analysis of reinforced concrete buildings 显示文摘 | Park Y J Ang H S | 1985 | ASCE Journal of Structural Engineering1985，111，4： | 1 |
| 8 | Total Factor Carbon Emission Per-formance :A Malmquist Index Analysis 显示文摘 | Zhou P Ang B W Han J Y | 2010 | Enei^y Economics2010，32，1： | 1 |
| 9 | Mechanistic seismic damagemodel for reinforced concrete 显示文摘 | PARK Y J ANG A H-S | 1985 | Journal of StructuralEngineering ASCE1985，111，4： | 1 |
| 10 | Seismic damage analysis of reinforced concrete buildings 显示文摘 | PARK Y J ANG H S WEN Y K | 1985 | Journal of Structural Engineering1985，111，4： | 1 |
| 11 | Mechanistic seismic damage model for reinforced concrete 显示文摘 | Park Y J Ang AHS | 1985 | Journal of Structural Engineering1985，111，4： | 1 |
| 12 | Mechanistic seismic damage model for reinforced concrete 显示文摘 | Park Y J Ang A H S | 1985 | Journal of Structural Engineering ASCE1985，111，4： | 1 |
| 13 | Walk the Line: Station Context, Corridor Type and Bus Rapid Transit Walk Access in Jinan, China显示文摘 | J]ANG Y ZEGRAS P C MEHNDIRA3FA S | 2012 | Journal of Transport Geog- raphy2012，20，1： | 1 |
| 14 | Mechanistic seismic damage model for reinforced concrete显示文摘 | Park Y J Ang A H S | 1985 | Journal of Structural Engineering1985，111，4： | 1 |
| 15 | Mechanistic seismic damage model for reinforced concrete 显示文摘 | Park Y J Ang A | 1985 | Journal of Structural Engineering ASCE1985，111，4： | 1 |
| 16 | Seismic damage analysis of reinforced concrete buildings 显示文摘 | Park Y - J Ang AHS Wen YK | 1985 | Journal of Structural Engineering1985，111，4： | 1 |
| 17 | Mechanistic seismic damage model for reinforced concrete显示文摘 | Park Y J Ang A H S | 1985 | Journal of Structural Engineering1985，111，4： | 1 |
| 18 | Narcissism, extraversionand adolescents,self - presentation on Facebook 显示文摘 | Ong E Y L Ang R P Ho J C M | 2010 | Personality andIndividual Differences2010，50，2： | 1 |
| 19 | Mechanistic seismic damage model of reinforced concrete 显示文摘 | Park Y J Ang H S | 1955 | Journal of Structural Engineering (ASCE)1955，111，： | 1 |
| 20 | Mechanistic seismic damage model for reinforced concrete 显示文摘 | Park Y J Ang A H | 1985 | Journal of Structural Division ASCE1985，111，4： | 1 |
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