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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 4 | Rotavirus vac- cines: recent developments and future considerations 显示文摘 | ANGEL J FRANCO M A GREENBERG H B | 2007 | Nat Rev Microbiol2007，5，7： | 1 |
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| 6 | Comparative assessment of solid-phase extraction clean-up procedures,GC columns and perfluoroacylation reagents for determination of type B trichothecenes in wheat by GC-ECD显示文摘 | FRANCISCO M V A ANGEL M JOS(E) V G A | 2005 | Talanta2005，66，： | 1 |
| 7 | RANKL/OPG in primary cultures of osteoblasts from post-menopausal women. Differences between osteoporotic hip fractures and osteoarthritis显示文摘 | Mercè Giner M a José Rios M a José Montoya M a Angeles Vázquez Latifa Naji Ramón Pérez-Cano | 2008 | Journal of Steroid Biochemistry and Molecular Biology2008，，1： | 1 |
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| 9 | Metabolic phenotyping of genetically modified mice: An NMR metabonomic approach显示文摘 | Rull A Vinaixa M Angel Rodriguez M | 2009 | Biochimie2009，91，8： | 1 |
| 10 | Emission enhancement mechanisms in dual-pulse LIBS 显示文摘 | SCAFFIDI J M ANGEL S CREMERS D A | 2006 | Analytical Chemistry2006，78，1： | 1 |
| 11 | Genetics of resistance of rice cultivar ARC10550 to Bangladesh brown pianthopper teletype显示文摘 | Gurdev S Khush A N M Rezaul Karim E R Angeles | 1985 | Journal of Genetics (-)1985，，2： | 1 |
| 12 | Angiotensinconverting enzyme genotype and physical performance during US Army basic training显示文摘 | Sonna L A Cullivan M Angel K C | 2001 | J Appl Physiol2001，91，3： | 1 |
| 13 | A thermodynamic connection to the fragility of glass-forming liquids显示文摘 | Martinez L M Angell C A | | 0，，： | 1 |
| 14 | Changes in polyamines synthesisduring anther development and pollen germination in tobacco (Nicotiana tabacum ) 显示文摘 | Fatiha C Angel J M Trimindad A | 1994 | Physiol Plant1994，92，： | 1 |
| 15 | Cytokinin oxidase regulates rice grain production显示文摘 | Ashikari M Sakakibara H Lin S Y Yamamoto T Takashi T Nishimura A Angeles E R Qian Q Kitano H Matsuoka M | 2005 | Science2005，309，： | 1 |
| 16 | Identification of grass carp hemorrhage virus as a new genogroup of aquareovirus显示文摘 | Angel A A Rockemann D D Hetrick F M | 1999 | J Gen Virol1999，80，： | 1 |
| 17 | Validation of microcosms for examing the survival of Pseudomonas aureofaciens (lacZY) in soil 显示文摘 | Angel J S Levin M A Gagliardi J V | 1995 | Applied and Environmental Microbiology1995，61，8： | 1 |
| 18 | Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease 显示文摘 | Shawnd A Angel JB Lunau M | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 19 | Mechanistical and non-linear modeling approaches to in-duct desulfurization显示文摘 | Aurora G Jose A M Angel I | 2005 | Chemical Engineering and Processing2005，44，7： | 1 |
| 20 | Theory and Measurement of Acculturation 显示文摘 | Szapocznik J Scopetta M A Kurtines W de los Angeles Aranade M | 1978 | Interamerican Journal of Psychology1978，12，2： | 1 |
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